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Polyuridylic acid potassium salt - 98%, high purity , CAS No.27416-86-0

8 Citations
  • ≥98%
Item Number
P350073
Grouped product items
SKUSizeAvailabilityPrice Qty
P350073-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$119.90
P350073-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$237.90
P350073-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$427.90
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a single-stranded RNA model compound

Basic Description

Synonyms{[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid | AKOS016009839 | Uridine 5'-phosphorate | 2,4(1H,3H)-pyrimidinedione, 1-(5-O-phosphono-beta-D-ribofuranosyl)- | W-105350 | W-203212 | bmse0002
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Polyuridylic acid potassium salt is a single-stranded RNA model compound often in comparison with other ssRNA model oligonucleotides such as Poly(I) and Poly(C) to study processes that are dependent upon ssRNA regulation such as Toll-like receptor regulation. Poly(U) is used as an effective agonist for TLR7.

Associated Targets(Human)

CRBN Tclin Protein cereblon (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RGS4 Tchem Regulator of G-protein signaling 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AGO2 Tbio Protein argonaute-2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
UMPS Tclin Uridine 5'-monophosphate synthase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CMPK1 Tchem UMP-CMP kinase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
P2RY6 Tchem P2Y purinoceptor 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
P2RY6 Tchem Pyrimidinergic receptor P2Y6 (717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UMPS Tclin Uridine 5'-monophosphate synthase (20 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CMPK1 Tchem UMP-CMP kinase (152 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CRBN Tclin Protein cereblon (139 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

ompdc Orotidine phosphate decarboxylase (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pyrF Orotidine 5'-phosphate decarboxylase (39 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
INCHI InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChi Key DJJCXFVJDGTHFX-XVFCMESISA-N
Canonical SMILES C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)O)O)O
Isomeric SMILES C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O
WGK Germany 3
PubChem CID 6030

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
L2315451Certificate of AnalysisDec 01, 2023 P350073
L2315452Certificate of AnalysisDec 01, 2023 P350073
L2315453Certificate of AnalysisDec 01, 2023 P350073
L2315454Certificate of AnalysisDec 01, 2023 P350073
L2315455Certificate of AnalysisDec 01, 2023 P350073
L2315456Certificate of AnalysisDec 01, 2023 P350073

Chemical and Physical Properties

SolubilitySoluble in water (20 mg/ml), and 0.1 N KPO4 buffer, pH 7.0 (10 mg/ml).

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. Polyuridylic acid sodium salt
    Polyuridylic acid sodium salt
    • ≥85%

    Starting at $500.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Lai Liang, Zhang Mengyun, Liu Chusheng, Qu Jiahuan, Xu Dongsheng, Jiang Zhengjin.  (2023)  A comprehensive evaluation of a polymeric zwitterionic hydrophilic monolith for nucleotide separation.  ANALYTICAL SCIENCES,    (1-7).  [PMID:37843729] [10.1007/s44211-023-00430-5]
2. Xu Shichao, Wu Haifeng, Liu Siyuan, Du Peidong, Wang Hui, Yang Haijun, Xu Wenjie, Chen Shuangming, Song Li, Li Jikun, Shi Xinghua, Wang Zhen-Gang.  (2023)  A supramolecular metalloenzyme possessing robust oxidase-mimetic catalytic function.  Nature Communications,  14  (1): (1-14).  [PMID:37419896] [10.1038/s41467-023-39779-6]
3. Peidong Du, Yanzhe Shen, Baoli Zhang, Shan Li, Minzheng Gao, Ting Wang, Xiaokang Ding, Bingran Yu, Zhen-Gang Wang, Fu-Jian Xu.  (2023)  A H2O2-Supplied Supramolecular Material for Post-irradiated Infected Wound Treatment.  Advanced Science,  10  (9): (2206851).  [PMID:36709479] [10.1002/advs.202206851]
4. Yuqin Wang, Pingping Fan, Shanyu Zhang, Liying Wang, Xinyue Li, Wendong Jia, Yao Liu, Kefan Wang, Xiaoyu Du, Panke Zhang, Shuo Huang.  (2022)  Discrimination of Ribonucleoside Mono-, Di-, and Triphosphates Using an Engineered Nanopore.  ACS Nano,  16  (12): (21356–21365).  [PMID:36475606] [10.1021/acsnano.2c09662]
5. Guimei Wang, Xiaoxue Jiang, Nanyan Fu.  (2019)  Near-infrared squaraine fluorescent probe for imaging adenosine 5′-triphosphate in live cells.  DYES AND PIGMENTS,  171  (107698).  [PMID:] [10.1016/j.dyepig.2019.107698]
6. Qiqin Wang, Huihui Wu, Kun Peng, Hanying Jin, Huikai Shao, Yuqiang Wang, Jacques Crommen, Zhengjin Jiang.  (2018)  Hydrophilic polymeric monoliths containing choline phosphate for separation science applications.  ANALYTICA CHIMICA ACTA,  999  (184).  [PMID:29254571] [10.1016/j.aca.2017.11.032]
7. Chen Zhao, Yan Yang, Linfang Wei, Qinghua Guo, Hao Fang, Shaolin Chen, Qiang Hua.  (2017)  Simultaneous determination of intracellular nucleotides and coenzymes in Yarrowia lipolytica producing lipid and lycopene by capillary zone electrophoresis.  JOURNAL OF CHROMATOGRAPHY A,  1514  (120).  [PMID:28760603] [10.1016/j.chroma.2017.07.074]
8. Chusheng Liu, Haibin Li, Qiqin Wang, Jacques Crommen, Haibo Zhou, Zhengjin Jiang.  (2017)  Preparation and evaluation of 400 μm I.D. polymer-based hydrophilic interaction chromatography monolithic columns with high column efficiency.  JOURNAL OF CHROMATOGRAPHY A,  1509  (83).  [PMID:28629939] [10.1016/j.chroma.2017.06.034]

References

1. Lai Liang, Zhang Mengyun, Liu Chusheng, Qu Jiahuan, Xu Dongsheng, Jiang Zhengjin.  (2023)  A comprehensive evaluation of a polymeric zwitterionic hydrophilic monolith for nucleotide separation.  ANALYTICAL SCIENCES,    (1-7).  [PMID:37843729] [10.1007/s44211-023-00430-5]
2. Xu Shichao, Wu Haifeng, Liu Siyuan, Du Peidong, Wang Hui, Yang Haijun, Xu Wenjie, Chen Shuangming, Song Li, Li Jikun, Shi Xinghua, Wang Zhen-Gang.  (2023)  A supramolecular metalloenzyme possessing robust oxidase-mimetic catalytic function.  Nature Communications,  14  (1): (1-14).  [PMID:37419896] [10.1038/s41467-023-39779-6]
3. Peidong Du, Yanzhe Shen, Baoli Zhang, Shan Li, Minzheng Gao, Ting Wang, Xiaokang Ding, Bingran Yu, Zhen-Gang Wang, Fu-Jian Xu.  (2023)  A H2O2-Supplied Supramolecular Material for Post-irradiated Infected Wound Treatment.  Advanced Science,  10  (9): (2206851).  [PMID:36709479] [10.1002/advs.202206851]
4. Yuqin Wang, Pingping Fan, Shanyu Zhang, Liying Wang, Xinyue Li, Wendong Jia, Yao Liu, Kefan Wang, Xiaoyu Du, Panke Zhang, Shuo Huang.  (2022)  Discrimination of Ribonucleoside Mono-, Di-, and Triphosphates Using an Engineered Nanopore.  ACS Nano,  16  (12): (21356–21365).  [PMID:36475606] [10.1021/acsnano.2c09662]
5. Guimei Wang, Xiaoxue Jiang, Nanyan Fu.  (2019)  Near-infrared squaraine fluorescent probe for imaging adenosine 5′-triphosphate in live cells.  DYES AND PIGMENTS,  171  (107698).  [PMID:] [10.1016/j.dyepig.2019.107698]
6. Qiqin Wang, Huihui Wu, Kun Peng, Hanying Jin, Huikai Shao, Yuqiang Wang, Jacques Crommen, Zhengjin Jiang.  (2018)  Hydrophilic polymeric monoliths containing choline phosphate for separation science applications.  ANALYTICA CHIMICA ACTA,  999  (184).  [PMID:29254571] [10.1016/j.aca.2017.11.032]
7. Chen Zhao, Yan Yang, Linfang Wei, Qinghua Guo, Hao Fang, Shaolin Chen, Qiang Hua.  (2017)  Simultaneous determination of intracellular nucleotides and coenzymes in Yarrowia lipolytica producing lipid and lycopene by capillary zone electrophoresis.  JOURNAL OF CHROMATOGRAPHY A,  1514  (120).  [PMID:28760603] [10.1016/j.chroma.2017.07.074]
8. Chusheng Liu, Haibin Li, Qiqin Wang, Jacques Crommen, Haibo Zhou, Zhengjin Jiang.  (2017)  Preparation and evaluation of 400 μm I.D. polymer-based hydrophilic interaction chromatography monolithic columns with high column efficiency.  JOURNAL OF CHROMATOGRAPHY A,  1509  (83).  [PMID:28629939] [10.1016/j.chroma.2017.06.034]

Solution Calculators

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