Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P125813-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $9.90 | |
P125813-50mg | 50mg | In stock | $11.90 | |
P125813-250mg | 250mg | In stock | $12.90 | |
P125813-1g | 1g | In stock | $13.90 | |
P125813-5g | 5g | In stock | $41.90 | |
P125813-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $66.90 | |
P125813-25g | 25g | In stock | $132.90 | |
P125813-100g | 100g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $419.90 |
Inhibits LPS-induced TNF-α. Antiangiogenic agent.
Synonyms | Pomalidomide (CC-4047) | POMALIDOMIDE [EMA EPAR] | POMALIDOMIDE [WHO-DD] | SCHEMBL369172 | BCP02890 | DTXCID801323473 | Pomalyst | IMID-3 | 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione | LACTONE | SR-01000941573 | AC-26970 | MLS006011261 | AKOS0 |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key γ-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).Pomalidomide is a second generation immunomodulato |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | CRL4(CRBN) E3 ubiquitin ligase inhibitor |
Note | 250mg,50mg,10mg卖完停产,不再备货。Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM. Application: Pomalidomide has been used:to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides;for apoptosis studies and intracellular calcium analysis;as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells. |
ALogP | 0.2 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
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INCHI | InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18) |
InChi Key | UVSMNLNDYGZFPF-UHFFFAOYSA-N |
Canonical SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N |
Isomeric SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N |
WGK Germany | 2 |
PubChem CID | 134780 |
Molecular Weight | 273.24 |
ChEMBL Ligand | CHEMBL43452 |
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DrugBank Ligand | DB08910 |
PubChem CID | 134780 |
Wikipedia | Pomalidomide |
CAS Registry No. | 19171-19-8 |
Reactome Reaction | R-HSA-9681169 |
Reactome Drug | R-ALL-9681202 |
DrugCentral Ligand | 4746 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L2411823 | Certificate of Analysis | Nov 29, 2024 | P125813 |
L2411825 | Certificate of Analysis | Nov 29, 2024 | P125813 |
L2411834 | Certificate of Analysis | Nov 29, 2024 | P125813 |
H2229680 | Certificate of Analysis | Jun 12, 2024 | P125813 |
E2411054 | Certificate of Analysis | Jul 28, 2022 | P125813 |
H2229499 | Certificate of Analysis | Jul 28, 2022 | P125813 |
H2229500 | Certificate of Analysis | Jul 28, 2022 | P125813 |
H2229501 | Certificate of Analysis | Jul 28, 2022 | P125813 |
H2229678 | Certificate of Analysis | Jul 28, 2022 | P125813 |
H2229683 | Certificate of Analysis | Jul 28, 2022 | P125813 |
Solubility | Soluble in DMSO (55 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), 1% DMSO/30% polyethylene glycol/1% Tween 80 (15 mg/ml at 25 °C), and THF (sparingly). |
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Sensitivity | Heat Sensitive |
Flash Point(°F) | 66.2 °F |
Flash Point(°C) | 66.2°F |
Melt Point(°C) | 315.5-317.5°C |
Pictogram(s) | GHS08 |
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Signal | Danger |
Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H360Df:May damage the unborn child; Suspected of damaging fertility H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
WGK Germany | 2 |
Merck Index | 135 |
1. Mingming Qi, Hui Zhong, Zhaoyan Cheng, Shujie Chen, Han Xiao, Jing Shang, Li Chen, Jianbo Sun. (2023) Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1. JOURNAL OF MEDICINAL CHEMISTRY, [PMID:37386884] [10.1021/acs.jmedchem.3c00822] |
1. Xin W, Xiaohua N, Peilin C, Xin C, Yaqiong S, Qihan W. (2008) Primary function analysis of human mental retardation related gene CRBN.. Mol Biol Rep, 35 (2): (251-6). [PMID:17380424] [10.1021/op500134e] |
2. Jo S, Lee KH, Song S, Jung YK, Park CS. (2005) Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain.. J Neurochem, 94 (5): (1212-24). [PMID:16045448] [10.1021/op500134e] |
3. Ito T, Ando H, Suzuki T, Ogura T, Hotta K, Imamura Y, Yamaguchi Y, Handa H. (2010) Identification of a primary target of thalidomide teratogenicity.. Science, 327 (5971): (1345-50). [PMID:20223979] [10.1021/op500134e] |
4. Lopez-Girona A, Mendy D, Ito T, Miller K, Gandhi AK, Kang J, Karasawa S, Carmel G, Jackson P, Abbasian M et al.. (2012) Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.. Leukemia, 26 (11): (2326-35). [PMID:22552008] [10.1021/op500134e] |
5. Zhu YX, Kortuem KM, Stewart AK. (2013) Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma.. Leuk Lymphoma, 54 (4): (683-7). [PMID:22966948] [10.1021/op500134e] |
6. Mingming Qi, Hui Zhong, Zhaoyan Cheng, Shujie Chen, Han Xiao, Jing Shang, Li Chen, Jianbo Sun. (2023) Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1. JOURNAL OF MEDICINAL CHEMISTRY, [PMID:37386884] [10.1021/acs.jmedchem.3c00822] |