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Posaconazole - ≥99%, high purity , Cytochrome P450 51 inhibitor, CAS No.171228-49-2, Cytochrome P450 51 inhibitor
Basic Description Synonyms Posaconazole|171228-49-2|Noxafil|Sch 56592|SCH-56592|Posaconazole SP|SCH56592|Schering 56592|(-)-POSACONAZOLE|UNII-6TK1G07BHZ|4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S, Specifications & Purity Moligand™, ≥99% Biochemical and Physiological Mechanisms Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Posaconazole is a sterol C14ɑ demethylase inhibitor
Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Cytochrome P450 51 inhibitor Note 5mg、10mg卖完停产，不再备货 Product Description Product Application：
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.Posaconazole may have been used as reference standard in HPLC analysis for quantification of posaconazole from human plasma.
Names and Identifiers IUPAC Name 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one INCHI InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1 InChi Key RAGOYPUPXAKGKH-XAKZXMRKSA-N Canonical SMILES CCC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5CC(OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F Isomeric SMILES CC[C@@H]([C@H](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F PubChem CID 468595 Molecular Weight 700.78
Chemical and Physical Properties Solubility DMSO 140 mg/mL Water <1 mg/mL Ethanol <1 mg/mL Sensitivity Heat Sensitive Specific Rotation[α] -26° (C=1,CHCl3) Melt Point(°C) 169 °C
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS09 , GHS07 Signal Danger Hazard Statements H319: Causes serious eye irritation
H351: Suspected of causing cancer
H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
H372: Causes damage to organs through prolonged or repeated exposure
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P391: Collect spillage.
P203: Obtain, read and follow all safety instructions before use.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P318: if exposed or concerned, get medical advice.
P337+P317: If eye irritation persists: Get medical help.
P319: Get medical help if you feel unwell.
Merck Index 7602
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H2224076