PP1 - ≥98%, high purity , CAS No.172889-26-8, Inhibitor of C-terminal Src kinase;Inhibitor of epidermal growth factor receptor;Inhibitor of FYN proto-oncogene; Src family tyrosine kinase;Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of mitogen-activated protein kinase 14;Inhib

Item Number

P126623

• Synonyms: 1-(tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 12L-341S | 4-AMINO-1-TERT-BUTYL-3-(4-METHYLPHENYL)PYRAZOLO[3,4-D]PYRIMIDINE | HMS3652F20 | CS-1662 | HMS2191A04 | KBio2_002942 | MLS000326642 | PP1 | PP-1 | 1-tert-butyl-3-(p-tolyl)-1h-pyraz
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Potent inhibitor of Src-family tyrosine kinases. Inhibits p56lckand p59fynT(IC50values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of C-terminal Src kinase;Inhibitor of epidermal growth factor receptor;Inhibitor of FYN proto-oncogene; Src family tyrosine kinase;Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of mitogen-activated protein kinase 14;Inhib

Product Description

Application:
PP1 has been used as:
an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)

PP1 is a potent and selective Src inhibitor for Lck/Fyn with IC50 of 5 nM/ 6 nM.
A selective and potent Src family tyrosine kinase inhibitor.