PP1 - 10mM in DMSO, high purity , CAS No.172889-26-8(DMSO)

Item Number

P580479

• Synonyms: 172889-26-8 | PP1 | 1-(tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | PP 1 | PYRAZOLOPYRIMIDINE 1 | PP-1 | 1-tert-butyl-3-(4-methylphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | SA2ND7EHY4 | PP-1 (enzyme inhibitor) | 1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,
• Specifications & Purity: Moligand™, 10mM in DMSO
• Biochemical and Physiological Mechanisms: Potent inhibitor of Src-family tyrosine kinases. Inhibits p56lckand p59fynT(IC50values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

Application:
PP1 has been used as:
an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)

PP1 is a potent and selective Src inhibitor for Lck/Fyn with IC50 of 5 nM/ 6 nM.
A selective and potent Src family tyrosine kinase inhibitor.