Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P125361-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $19.90 | |
P125361-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $77.90 | |
P125361-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $351.90 | |
P125361-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $639.90 |
Src and RIP2 kinase inhibitor
Synonyms | AG 1879 | 4few | KBioGR_000458 | Q7120082 | 2zv9 | BRD-K95785537-001-10-8 | BDBM50142887 | C73316 | Oprea1_738267 | AMY14185 | GTPL9404 | PP2 - CAS 172889-27-9 | 4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine | SCHEMBL375322 | 1-tert-b |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | PP 2 is an effective and selective inhibitor of c-Src family kinases. The inhibitor has been shown to inhibit Lck, FynT, phosphorylation of focal adhesion kinase (FAK) and potently inhibits Hck, Lck (p56) and Fyn (p59). Additionally, PP 2 was reported to |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of FYN proto-oncogene; Src family tyrosine kinase;Inhibitor of LCK proto-oncogene; Src family tyrosine kinase |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | PP2, a Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM in cell-free assays, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine |
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INCHI | InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19) |
InChi Key | PBBRWFOVCUAONR-UHFFFAOYSA-N |
Canonical SMILES | CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)Cl)N |
Isomeric SMILES | CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)Cl)N |
Alternate CAS | 172889-27-9 |
PubChem CID | 4878 |
MeSH Entry Terms | 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo(3,4-d)pyrimidine;AG 1879;AG1879;PP2 cpd;Src family kinase inhibitor PP2 |
Molecular Weight | 301.77 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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D1912175 | Certificate of Analysis | Dec 06, 2022 | P125361 |
Solubility | DMSO 60 mg/mL Water <1 mg/mL Ethanol 2 mg/mL |
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Sensitivity | Air Sensitive,Heat Sensitive |
Refractive Index | 1.68 |
Boil Point(°C) | 493.54° C at 760 mmHg |
Melt Point(°C) | 193.32°C |
1. Haiping Liu, Haixiang Ma, Xingyue Zeng, Chengyan Wu, Srijan Acharya, Sarabjeet Kour Sudan, Xiaohan Zhang. (2023) Ubiquitination of GRK2 Is Required for the β-Arrestin-Biased Signaling Pathway of Dopamine D2 Receptors to Activate ERK Kinases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (12): (10031). [PMID:37373182] [10.3390/ijms241210031] |
2. Xiaoming Lin, Guangfei Wang, Ping Liu, Lei Han, Tong Wang, Kaili Chen, Yonglin Gao. (2021) Gallic acid suppresses colon cancer proliferation by inhibiting SRC and EGFR phosphorylation. Experimental and Therapeutic Medicine, 21 (6): (1-11). [PMID:33968169] [10.3892/etm.2021.10070] |
3. Yijun Li, Xinyu Wen, Min Nie, Qi Wang. (2017) Toward Subtle Manipulation of Fine Dendritic β-Nucleating Agent in Polypropylene. ACS Omega, 2 (10): (7230–7238). [PMID:31457299] [10.1021/acsomega.7b01036] |
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14. Lee EJ et al.. (2015) Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation.. Nat Commun, 6 (7168). [PMID:25981743] |
15. Haiping Liu, Haixiang Ma, Xingyue Zeng, Chengyan Wu, Srijan Acharya, Sarabjeet Kour Sudan, Xiaohan Zhang. (2023) Ubiquitination of GRK2 Is Required for the β-Arrestin-Biased Signaling Pathway of Dopamine D2 Receptors to Activate ERK Kinases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (12): (10031). [PMID:37373182] [10.3390/ijms241210031] |
16. Xiaoming Lin, Guangfei Wang, Ping Liu, Lei Han, Tong Wang, Kaili Chen, Yonglin Gao. (2021) Gallic acid suppresses colon cancer proliferation by inhibiting SRC and EGFR phosphorylation. Experimental and Therapeutic Medicine, 21 (6): (1-11). [PMID:33968169] [10.3892/etm.2021.10070] |
17. Yijun Li, Xinyu Wen, Min Nie, Qi Wang. (2017) Toward Subtle Manipulation of Fine Dendritic β-Nucleating Agent in Polypropylene. ACS Omega, 2 (10): (7230–7238). [PMID:31457299] [10.1021/acsomega.7b01036] |