PP242 - ≥98%, high purity , CAS No.1092351-67-1, Inhibitor of mechanistic target of rapamycin kinase;Inhibitor of PAS domain containing serine/threonine kinase

Item Number

P129635

• Synonyms: 1H-Indol-5-ol, 2-(4-amino-1-(1-methylethyl)-1H-pyrazolo(3,4-d)pyrimidin-3-yl)- | BDBM36409 | BR164372 | UNII-H5669VNZ7V | O,N-dimethylhydroxyl-amine hydrochloride | SCHEMBL298922 | 2-[4-Amino-1-(Propan-2-Yl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]-1h-Indol-5-Ol
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: PP242 has been shown to be a an ATP-competitive mTORC1/mTORC2 (FRAP) inhibitor (IC50 = 8 nM). PP242 is the first selective inhibitor that targets the ATP domain of FRAP. This compound shows selectivity for FRAP over other PI 3K family kinases (IC50 values
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of mechanistic target of rapamycin kinase;Inhibitor of PAS domain containing serine/threonine kinase
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively.
A selective FRAP inhibitor