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PP242 - ≥98%, high purity , CAS No.1092351-67-1, Inhibitor of mechanistic target of rapamycin kinase;Inhibitor of PAS domain containing serine/threonine kinase

Moligand™
≥98%

CAS#: 1092351-67-1
Formula: C₁₆H₁₆N₆O
Molecular Weight: 308.34
PubChem CID: 135565635

Item Number

P129635

Grouped product items
SKU	Size	Availability	Price
P129635-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$64.90
P129635-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$84.90
P129635-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$169.90

Potent, selective and ATP-competitive mTOR inhibitor

View related series

mechanistic target of rapamycin kinase Inhibitor PAS domain containing serine/threonine kinase Inhibitor

Basic Description

Synonyms	PP242\|1092351-67-1\|TORKinib\|PP-242\|PP 242\|2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol\|Torkinib (PP242)\|2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol\|H5669VNZ7V\|DTXSID5048685\|CHEBI:90679\|2-(4-Amino-
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mechanistic target of rapamycin kinase;Inhibitor of PAS domain containing serine/threonine kinase
Product Description	Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively. A selective FRAP inhibitor

Associated Targets

RET Tclin Proto-oncogene tyrosine-protein kinase receptor Ret 2 Activities

Discover Target: RET

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIP5K1C Tchem Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 Activities

Discover Target: PIP5K1C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCE Tchem Protein kinase C epsilon type 1 Activities

Discover Target: PRKCE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K19 Tchem Mitogen-activated protein kinase kinase kinase 19 1 Activities

Discover Target: MAP3K19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMPR1B Tchem Bone morphogenetic protein receptor type-1B 1 Activities

Discover Target: BMPR1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRSK1 Tchem Serine/threonine-protein kinase BRSK1 1 Activities

Discover Target: BRSK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVR2A Tchem Activin receptor type-2A 1 Activities

Discover Target: ACVR2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVR2B Tchem Activin receptor type-2B 1 Activities

Discover Target: ACVR2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVR1 Tchem Activin receptor type-1 1 Activities

Discover Target: ACVR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVRL1 Tchem Serine/threonine-protein kinase receptor R3 1 Activities

Discover Target: ACVRL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PASK Tchem PAS domain-containing serine/threonine-protein kinase 0 Activities

Discover Target: PASK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 1 Activities

Discover Target: JAK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP2K5 Tchem Dual specificity mitogen-activated protein kinase kinase 5 1 Activities

Discover Target: MAP2K5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MTOR Tclin Serine/threonine-protein kinase mTOR 6 Activities

Discover Target: MTOR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
INCHI	InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19)
InChi Key	MFAQYJIYDMLAIM-UHFFFAOYSA-N
Canonical SMILES	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(N3)C=CC(=C4)O)N
Isomeric SMILES	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(N3)C=CC(=C4)O)N
PubChem CID	135565635
Molecular Weight	308.34

CAS Registry No.

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ChEMBL Ligand

PubChem CID

RCSB PDB Ligand

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Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
L2325079	Certificate of Analysis	Dec 29, 2023	P129635
F1510068	Certificate of Analysis	Jan 19, 2023	P129635

References

1. Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R, Williams RL, Shokat KM, Knight ZA. (2008) Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.. Nat Chem Biol, 4 (11): (691-9). [PMID:18849971]
2. Zhang YM et al.. (2018) Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2.. Dev Cell, 45 (5): (580-594.e7). [PMID:29804876]

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