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PPIase-Parvulin inhibitor - ≥95%, high purity , CAS No.64005-90-9

  • ≥95%
Item Number
P341984
Grouped product items
SKUSizeAvailabilityPrice Qty
P341984-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$68.90
P341984-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$149.90
P341984-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$214.90
P341984-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$357.90
P341984-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$532.90
P341984-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$749.90
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a Pin1/Pin4 PPIase activity inhibitor

View related series
PI3K/Akt/mTOR

Basic Description

Synonymsethyl 1,3,6,8-tetrahydro-1,3,6,8-tetraoxo-benzo[lmn] | NCGC00487158-02 | phenanthroline-2,7-diacetate | benzo[lmn][3,8]phenanthroline-2,7-diacetic acid, 1,3,6,8-tetrahydro-1,3,6,8-tetraoxo-, diethyl ester | HIC 016C | DTXSID00349244 | CCG-222565 | PiB | S
Specifications & Purity≥95%
Storage TempStore at 2-8°C,Protected from light,Argon charged
Shipped InWet ice
Product Description

PPIase-Parvulin Inhibitor is a cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties. PPIase-Parvulin Inhibitor causes cell cycle arrest and acts as a potent, competitive, selective, reversible, active site binding inhibitor of Pin1/Pin4 PPIase (peptidyl prolyl|cis-trans|isomerase) activity. It does not bind to DNA or functions as a topoisomerase I inhibitor.

Associated Targets(Human)

PIN4 Tbio Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PIN4 Tbio Peptidyl-prolyl cis-trans isomerase NIMA-interacting 2 (7 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name ethyl 2-[13-(2-ethoxy-2-oxoethyl)-5,7,12,14-tetraoxo-6,13-diazatetracyclo[6.6.2.04,16.011,15]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]acetate
INCHI InChI=1S/C22H18N2O8/c1-3-31-15(25)9-23-19(27)11-5-7-13-18-14(8-6-12(17(11)18)20(23)28)22(30)24(21(13)29)10-16(26)32-4-2/h5-8H,3-4,9-10H2,1-2H3
InChi Key WNKQGFNIIHNGQM-UHFFFAOYSA-N
Canonical SMILES CCOC(=O)CN1C(=O)C2=C3C(=CC=C4C3=C(C=C2)C(=O)N(C4=O)CC(=O)OCC)C1=O
Isomeric SMILES CCOC(=O)CN1C(=O)C2=C3C(=CC=C4C3=C(C=C2)C(=O)N(C4=O)CC(=O)OCC)C1=O
WGK Germany 3
PubChem CID 643974
UN Number 3077
Packing Group III
Molecular Weight 438.39

Certificates

Certificate of Analysis(COA)

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11 results found

Lot NumberCertificate TypeDateItem
I2402294Certificate of AnalysisJul 30, 2024 P341984
I2402295Certificate of AnalysisJul 30, 2024 P341984
I2402296Certificate of AnalysisJul 30, 2024 P341984
I2402297Certificate of AnalysisJul 30, 2024 P341984
I2402298Certificate of AnalysisJul 30, 2024 P341984
I2402299Certificate of AnalysisJul 30, 2024 P341984
I2402300Certificate of AnalysisJul 30, 2024 P341984
I2402301Certificate of AnalysisJul 30, 2024 P341984
I2402302Certificate of AnalysisJul 30, 2024 P341984
I2402303Certificate of AnalysisJul 30, 2024 P341984
I2402397Certificate of AnalysisJul 30, 2024 P341984

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Chemical and Physical Properties

SolubilitySoluble in chloroform (1 mg/ml), and ethanol (250 μg/ml, cloudy suspension).
SensitivityLight sensitive
Refractive Indexn20D1.64 (Predicted)
Boil Point(°C)636.46° C at 760 mmHg (Predicted)
Melt Point(°C)>300° C

Safety and Hazards(GHS)

Pictogram(s) GHS09
Signal Warning
Hazard Statements

H400:Very toxic to aquatic life

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

P391:Collect spillage.

WGK Germany 3
Class 9
RIDADR NONHforallmodesoftransport

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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