PQ 401 - ≥99%, high purity , CAS No.196868-63-0, Inhibitor of Insulin-like growth factor I receptor

Item Number

P125823

• Synonyms: 196868-63-0 | PQ401 | 1-(5-Chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea | PQ 401 | PQ-401 | IGF-1R Inhibitor II | TCMDC-125497 | N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea | 2N3LV83S8J | CHEMBL439259 | Urea, N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: PQ401 is a cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation. The mechanism of inhibition likely involves indirect blocking of ATP binding. PQ401 also decreases IGF-1R-dependent tumor cell growth in vitro.Cell-permeabl
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of Insulin-like growth factor I receptor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
An inhibitor of IGF-1R autophosphorylation.