Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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P126704-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $88.90 | |
P126704-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $241.90 | |
P126704-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,089.90 |
Cell-permeable, non-selective and reversible DUB inhibitor
Synonyms | 3,5-Bis-thiocyanato-pyridine-2,6-diamine | Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester | HMS1440E01 | IDI1_014644 | s7130 | SW208365-2 | (2,6-diamino-5-thiocyanato-3-pyridyl) thiocyanate | HMS3874D13 | 2,6-Diamino-3,5-dithiocyanopyridine | |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | PR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.Cell-permeable, non-selective and reversible DUB inh |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate |
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INCHI | InChI=1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12) |
InChi Key | ZXOBLNBVNROVLC-UHFFFAOYSA-N |
Canonical SMILES | C1=C(C(=NC(=C1SC#N)N)N)SC#N |
Isomeric SMILES | C1=C(C(=NC(=C1SC#N)N)N)SC#N |
WGK Germany | 3 |
PubChem CID | 2817763 |
Molecular Weight | 223.28 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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F1515088 | Certificate of Analysis | Oct 16, 2024 | P126704 |
Solubility | 25°C: DMSO 45 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL |
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Pictogram(s) | GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H335:May cause respiratory irritation H302:Harmful if swallowed H318:Causes serious eye damage H317:May cause an allergic skin reaction |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
WGK Germany | 3 |
1. Ohsugi T et al.. (2019) Anti-apoptotic effect by the suppression of IRF1 as a downstream of Wnt/ß-catenin signaling in colorectal cancer cells.. Oncogene, 38 (32): (6051-6064). [PMID:31292489] |
2. Tyagi A et al.. (2022) CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells.. Theranostics, 12 (13): (5949-5970). [PMID:35966591] |
3. Skelly MJ et al.. (2019) Dynamic ubiquitination determines transcriptional activity of the plant immune coactivator NPR1.. Elife, 8 [PMID:31589140] |
4. Das S et al.. (2020) Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer.. Cell Death Differ, [PMID:32415280] |
5. Ashkenazi A et al.. (2017) Polyglutamine tracts regulate beclin 1-dependent autophagy.. Nature, 545 (7652): (108-111). [PMID:28445460] |
6. Cao WX et al.. (2020) Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition.. Cell Rep, 31 (12): (107783). [PMID:32579915] |
7. Inano S et al.. (2017) RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination.. Mol Cell, 66 (5): (622-634.e8). [PMID:28575658] |
8. Tsuchiya H et al.. (2018) Ub-ProT reveals global length and composition of protein ubiquitylation in cells.. Nat Commun, 9 (524). [PMID:29410401] |