PR-619 - ≥98%, high purity , CAS No.2645-32-1

  • ≥98%
Item Number
P126704
Grouped product items
SKUSizeAvailabilityPrice Qty
P126704-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$88.90
P126704-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$241.90
P126704-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,089.90

Cell-permeable, non-selective and reversible DUB inhibitor

Basic Description

Synonyms3,5-Bis-thiocyanato-pyridine-2,6-diamine | Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester | HMS1440E01 | IDI1_014644 | s7130 | SW208365-2 | (2,6-diamino-5-thiocyanato-3-pyridyl) thiocyanate | HMS3874D13 | 2,6-Diamino-3,5-dithiocyanopyridine |
Specifications & Purity≥98%
Biochemical and Physiological MechanismsPR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.Cell-permeable, non-selective and reversible DUB inh
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM.

Associated Targets(Human)

USP5 Tchem Ubiquitin carboxyl-terminal hydrolase 5 (172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP2 Tbio Ubiquitin carboxyl-terminal hydrolase 2 (8818 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (837 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP8 Tchem Ubiquitin carboxyl-terminal hydrolase 8 (245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP9X Tbio Probable ubiquitin carboxyl-terminal hydrolase FAF-X (500 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP4 Tchem Ubiquitin carboxyl-terminal hydrolase 4 (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate
INCHI InChI=1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12)
InChi Key ZXOBLNBVNROVLC-UHFFFAOYSA-N
Canonical SMILES C1=C(C(=NC(=C1SC#N)N)N)SC#N
Isomeric SMILES C1=C(C(=NC(=C1SC#N)N)N)SC#N
WGK Germany 3
PubChem CID 2817763
Molecular Weight 223.28

Certificates

Certificate of Analysis(COA)

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Lot NumberCertificate TypeDateItem
F1515088Certificate of AnalysisOct 16, 2024 P126704

Chemical and Physical Properties

Solubility 25°C: DMSO 45 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL

Safety and Hazards(GHS)

Pictogram(s) GHS05,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

H318:Causes serious eye damage

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

WGK Germany 3

Related Documents

References

1. Ohsugi T et al..  (2019)  Anti-apoptotic effect by the suppression of IRF1 as a downstream of Wnt/ß-catenin signaling in colorectal cancer cells..  Oncogene,  38  (32): (6051-6064).  [PMID:31292489]
2. Tyagi A et al..  (2022)  CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells..  Theranostics,  12  (13): (5949-5970).  [PMID:35966591]
3. Skelly MJ et al..  (2019)  Dynamic ubiquitination determines transcriptional activity of the plant immune coactivator NPR1..  Elife,    [PMID:31589140]
4. Das S et al..  (2020)  Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer..  Cell Death Differ,      [PMID:32415280]
5. Ashkenazi A et al..  (2017)  Polyglutamine tracts regulate beclin 1-dependent autophagy..  Nature,  545  (7652): (108-111).  [PMID:28445460]
6. Cao WX et al..  (2020)  Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition..  Cell Rep,  31  (12): (107783).  [PMID:32579915]
7. Inano S et al..  (2017)  RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination..  Mol Cell,  66  (5): (622-634.e8).  [PMID:28575658]
8. Tsuchiya H et al..  (2018)  Ub-ProT reveals global length and composition of protein ubiquitylation in cells..  Nat Commun,  (524).  [PMID:29410401]

Solution Calculators