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Pracinostat (SB939) - ≥98%, high purity , CAS No.929016-96-6, Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 10;Inhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 5

Specifications & Purity: ≥98%

CAS#: 929016-96-6
Formula: C₂₀H₃₀N₄O₂
Molecular Weight: 358.48
PubChem CID: 49855250

Item Number

P127910

Grouped product items
SKU	Size	Availability	Price
P127910-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$124.90
P127910-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$216.90
P127910-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$771.90

Potent HDAC inhibitor

View related series

histone deacetylase 1 Inhibitor histone deacetylase 10 Inhibitor histone deacetylase 3 Inhibitor histone deacetylase 5 Inhibitor

Basic Description

Synonyms	Pracinostat\|929016-96-6\|SB939\|SB 939\|Pracinostat (SB939)\|SB-939\|Pracinostat [INN]\|(E)-3-(2-butyl-1-(2-(diethylamino)ethyl)-1H-benzo[d]imidazol-5-yl)-N-hydroxyacrylamide\|Pracinostat(SB939)\|GPO2JN4UON\|CHEMBL1851943\|2-Propenamide, 3-(2-butyl-1-(2-(diethylami
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 10;Inhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 5

Associated Targets

HDAC4 Tclin Histone deacetylase 4 1 Activities

Discover Target: HDAC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 2 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC1 Tclin Histone deacetylase 1 4 Activities

Discover Target: HDAC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC7 Tclin Histone deacetylase 7 1 Activities

Discover Target: HDAC7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC11 Tclin Histone deacetylase 11 1 Activities

Discover Target: HDAC11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC9 Tclin Histone deacetylase 9 1 Activities

Discover Target: HDAC9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC2 Tclin Histone deacetylase 2 3 Activities

Discover Target: HDAC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC10 Tclin Histone deacetylase 10 3 Activities

Discover Target: HDAC10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC8 Tclin Histone deacetylase 8 3 Activities

Discover Target: HDAC8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC5 Tclin Histone deacetylase 5 2 Activities

Discover Target: HDAC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC3 Tclin Histone deacetylase 3 2 Activities

Discover Target: HDAC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide
INCHI	InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
InChi Key	JHDKZFFAIZKUCU-ZRDIBKRKSA-N
Canonical SMILES	CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)C=CC(=O)NO
Isomeric SMILES	CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)/C=C/C(=O)NO
PubChem CID	49855250
Molecular Weight	358.48

PubChem CID

CAS Registry No.

ChEMBL Ligand

Wikipedia

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1 results found

Lot Number	Certificate Type	Date	Item
F1511087	Certificate of Analysis	Jan 20, 2023	P127910

References

1. Liu L, Chen B, Qin S, Li S, He X, Qiu S, Zhao W, Zhao H. (2010) A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells.. Biochem Biophys Res Commun, 392 (2): (190-5). [PMID:20060381]
2. Novotny-Diermayr V, Sangthongpitag K, Hu CY, Wu X, Sausgruber N, Yeo P, Greicius G, Pettersson S, Liang AL, Loh YK et al.. (2010) SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer.. Mol Cancer Ther, 9 (3): (642-52). [PMID:20197387]
3. Mithraprabhu S, Grigoriadis G, Khong T, Spencer A. (2010) Deactylase inhibition in myeloproliferative neoplasms.. Invest New Drugs, 28 Suppl 1 (3): (S50-7). [PMID:21127942]
4. Prebet T, Vey N. (2011) Vorinostat in acute myeloid leukemia and myelodysplastic syndromes.. Expert Opin Investig Drugs, 20 (2): (287-95). [PMID:21192773]

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