Potent, selective, competitive CysLT 1 antagonist (IC 50 values are 7 and 3620 nM for CysLT 1 and CysLT 2 respectively). Shows bronchodilatory and antiasthmatic effects in vivo.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Cysteinyl leukotriene receptor 1 antagonist
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Properties
ALogP
4.2
Associated Targets
CNIH3Tbio Protein cornichon homolog 3 0 Activities
1.Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T et al.. (2019) Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.. Nat Commun, 10 (1):(5573). [PMID:31811124]
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B2322975