Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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P160142-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $16.90 | |
P160142-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $32.90 | |
P160142-250mg | 250mg | In stock | $64.90 | |
P160142-1g | 1g | In stock | $199.90 | |
P160142-5g | 5g | In stock | $897.90 | |
P160142-25g | 25g | In stock | $4,039.90 | |
P160142-100g | 100g | In stock | $14,543.90 |
Peripheral α adrenoceptor antagonist. Melatonin antagonist.
Synonyms | [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride | C19H21N5O4.HCl | Peripress | Prazosin (hydrochloride) | PRAZOSIN HYDROCHLORIDE (MART.) | SR-01000003052 | W-107719 | 2-{4-[(furan-2-yl)carbonyl]piperazin-1-yl}- |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.Periph |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Action Type | ANTAGONIST |
Mechanism of action | Adrenergic receptor alpha-1 antagonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder. razosin hydrochloride has been used: • to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice. • as an α1-adrenoceptor blocker,administered intragastrically in rats. • as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride |
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INCHI | InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H |
InChi Key | WFXFYZULCQKPIP-UHFFFAOYSA-N |
Canonical SMILES | COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl |
Isomeric SMILES | COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl |
WGK Germany | 3 |
RTECS | VA1350000 |
PubChem CID | 68546 |
Molecular Weight | 419.87 |
Beilstein | 4303560 |
Reaxy-Rn | 4303561 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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L2015089 | Certificate of Analysis | Oct 17, 2024 | P160142 |
L2015088 | Certificate of Analysis | Oct 17, 2024 | P160142 |
F2222450 | Certificate of Analysis | Jun 30, 2022 | P160142 |
F2205324 | Certificate of Analysis | Jun 08, 2022 | P160142 |
E2204203 | Certificate of Analysis | Feb 23, 2022 | P160142 |
E2204213 | Certificate of Analysis | Feb 23, 2022 | P160142 |
E2204214 | Certificate of Analysis | Feb 23, 2022 | P160142 |
E2204222 | Certificate of Analysis | Feb 23, 2022 | P160142 |
E2204223 | Certificate of Analysis | Feb 23, 2022 | P160142 |
Solubility | H2O: 0.5 mg/mL,methanol: 6 mg/mL,dilute aqueous acid: insoluble. |
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Sensitivity | Light Sensitive |
Melt Point(°C) | 285°C(lit.) |
Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | VA1350000 |
Reaxy-Rn | 4303561 |
Merck Index | 7717 |
1. Tyurin-Kuzmin PA et al.. (2016) Activation of ß-adrenergic receptors is required for elevated a1A-adrenoreceptors expression and signaling in mesenchymal stromal cells.. Sci Rep, 6 (32835). [PMID:27596381] |
2. Meitzen J et al.. (2011) ß1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.. J Neurochem, 116 (6): (984-95). [PMID:21143600] |