Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor (K i = 7.2 μM). Antiarrhythmic in vivo . Limited ability to cross the blood-brain barrier.
Storage Temp
Protected from light,Room temperature,Argon charged
Shipped In
Normal
Action Type
BLOCKER
Mechanism of action
Sodium channel alpha subunit blocker
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Product Application:
Procainamide hydrochloride (PAH) is suitable to investigate its binding behavior with human serum albumin and bovine serum albumin by fluorescence quenching study to understand the pharmacokinetic and pharmacodynamic mechanisms of PAH.
1.Hasan SS et al.. (2018) Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization.. Cell Rep, 25 (11):(3136-3147.e5). [PMID:30540945]
2.Derking R et al.. (2021) Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike.. Cell Rep, 35 (108933). [PMID:33826885]
3.Seabright GE et al.. (2020) Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions.. Structure, 28 (8):(897-909.e6). [PMID:32433992]
4.Struwe WB et al.. (2018) Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen.. Cell Rep, 24 (8):(1958-1966.e5). [PMID:30134158]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
I2104272