Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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P106427-25g | 25g | In stock | $150.90 |
Synonyms | Luteodyn | Progestron | Cyclogesterin | Hormoluton | Lucorteum | Utrogest | Gynolutone | Progesteronum [INN-Latin] | Progestol | Cyclogest | Progestone | Lutogyl | Progestin | Luteostab | Lutromone | Progesterona [INN-Spanish] | Gestiron | Luteol (VAN) | |
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Specifications & Purity | PharmPure™, USP |
Shipped In | Normal |
Grade | PharmPure™, USP |
Action Type | ACTIVATOR, AGONIST, ANTAGONIST, CHANNEL BLOCKER |
Mechanism of action | Activator of CatSper1;Activator of CatSper2;Activator of CatSper3;Activator of CatSper4;Antagonist of Mineralocorticoid receptor;Agonist of Progesterone receptor;Channel blocker of TRPC5 |
ALogP | 3.9 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
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INCHI | InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 |
InChi Key | RJKFOVLPORLFTN-LEKSSAKUSA-N |
Canonical SMILES | CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C |
Isomeric SMILES | CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C |
WGK Germany | 3 |
RTECS | TW0175000 |
PubChem CID | 5994 |
Molecular Weight | 314.47 |
Beilstein | 1915950 |
PubChem CID | 5994 |
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Wikipedia | Progesterone |
DrugBank Ligand | DB00396 |
ChEBI | CHEBI:17026 |
CAS Registry No. | 57-83-0 |
ChEMBL Ligand | CHEMBL103 |
NURSA Ligand | 10.1621/E7EEFRDJA5 |
RCSB PDB Ligand | STR |
PEP | progesterone |
DrugCentral Ligand | 2279 |
Enter Lot Number to search for COA:
Specific Rotation[α] | 182 ° (C=2, Dioxane) |
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Melt Point(°C) | 126-131°C |
Pictogram(s) | GHS08 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H360:May damage fertility or the unborn child H350:May cause cancer H361:Suspected of damaging fertility or the unborn child H362:May cause harm to breast-fed children |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | TW0175000 |
1. Juan Luo, Bowen Zhou, Chenjun Dong, Rongrong He, Yuling Zhang, Tao He. (2024) Effect of substrate morphology on characteristics of layer-by-layer self-assembly nanofiltration membrane for micropollutants removal. DESALINATION, 574 (117229). [PMID:] [10.1016/j.desal.2023.117229] |
2. Zu Qiang Jiang, Lei Zhang, Cui Juan Lan, Jian Ping Wang. (2023) Development of a Progesterone-Receptor-Based Pseudo-immunoassay for Multi-detection of Progestins in Milk and Studying Its Recognition Mechanism. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:37938156] [10.1021/acs.jafc.3c05890] |
3. Yan Su, Gelin Liu, Haozhe Hou, Yaojia Peng, Jianping Wang. (2023) Development of a Magnetic Molecularly Imprinted Microsphere-Based Signal Amplified Semi-Homogeneous Method for Multidetection of Five Progestins in Milk. Foods, 12 (15): (2818). [PMID:37569089] [10.3390/foods12152818] |
4. Xu Yang-ding, Guo Yu-jie, Mao He-rong, Xiong Zhi-xiang, Luo Meng-yu, Luo Rui-qi, Lu Shan, Huang Lu, Hong Yi. (2023) Integration of transcriptomics and proteomics to elucidate inhibitory effect and mechanism of rosmarinic acid from Perilla frutescens (L.) Britt. in treating Trichophyton mentagrophytes. Chinese Medicine, 18 (1): (1-20). [PMID:37280712] [10.1186/s13020-023-00772-2] |
5. Jing Yang, Hao Liu, Yan Huang, Li Li, Xiaoli Zhu, Yaping Ding. (2023) One-step hydrothermal synthesis of near-infrared emission carbon quantum dots as fluorescence aptamer sensor for cortisol sensing and imaging. TALANTA, 260 (124637). [PMID:37172433] [10.1016/j.talanta.2023.124637] |
6. Haoyu Long, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks. TALANTA, 260 (124589). [PMID:37126925] [10.1016/j.talanta.2023.124589] |
7. Zhefei Hu, Yanhao Jiang, Panpan Cao, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Performance evaluation of 2-undecylimidazole/propyl methacrylate bifunctional silica gel for mixed-mode reversed-phase/anion-exchange chromatography. MICROCHEMICAL JOURNAL, 191 (108768). [PMID:] [10.1016/j.microc.2023.108768] |
8. Jiameng Liu, Mengfei Wang, Chuanpan Guo, Zheng Tao, Minghua Wang, Linghao He, Baozhong Liu, Zhihong Zhang. (2023) Defective porphyrin-based metal-organic framework nanosheets derived from V2CTx MXene as a robust bioplatform for impedimetric aptasensing 17β-estradiol. FOOD CHEMISTRY, 416 (135839). [PMID:36893636] [10.1016/j.foodchem.2023.135839] |
9. Ling Wang, Xiaowei Wu, Chenghua Gao, Lingrui Wei, Qian Li, Aitao Li. (2023) A Fungal P450 Enzyme from Fusarium graminearum with Unique 12β-Steroid Hydroxylation Activity. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 89 (3): [PMID:36853033] [10.1128/aem.01963-22] |
10. Nanjun Li, Chongyang Wang, Liangjun Chen, Cui Ye, Yongwu Peng. (2022) Ultrathin Covalent Organic Framework Nanosheets/Ti3C2Tx-Based Photoelectrochemical Biosensor for Efficient Detection of Prostate-Specific Antigen. MOLECULES, 27 (19): (6732). [PMID:36235265] [10.3390/molecules27196732] |
11. Yajiao Zhang, Minjie Liu, Huijing Wang, Juan Lin, Fener Chen. (2022) Focused mutagenesis in non-catalytic cavity for improving catalytic efficiency of 3-ketosteroid-Δ1-dehydrogenase. Molecular Catalysis, 531 (112661). [PMID:] [10.1016/j.mcat.2022.112661] |
12. Wenjing Wang, Fei Zhai, Fupei Xu, Min Jia. (2022) Enzyme-free amplified and one-step rapid detection of bisphenol A using dual-terminal labeled split aptamer probes. MICROCHEMICAL JOURNAL, 183 (107977). [PMID:] [10.1016/j.microc.2022.107977] |
13. Yan Wu, Panpan Cao, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Zhengwu Bai, Sheng Tang. (2022) Ingenious introduction of aminopropylimidazole to tune the hydrophobic selectivity of dodecyl-bonded stationary phase for environmental organic pollutants. MICROCHEMICAL JOURNAL, 182 (107933). [PMID:] [10.1016/j.microc.2022.107933] |
14. Huiyi Yang, Qiyi He, Mingxia Lin, Li Ji, Leheng Zhang, Huanxin Xiao, Shijia Li, Qinglan Li, Xiping Cui, Suqing Zhao. (2022) Multifunctional Au@Pt@Ag NPs with color-photothermal-Raman properties for multimodal lateral flow immunoassay. JOURNAL OF HAZARDOUS MATERIALS, 435 (129082). [PMID:35650752] [10.1016/j.jhazmat.2022.129082] |
15. Susu Lin, Bingbing Ma, Qilin Gao, Jian Yang, Gang Lai, Runhao Lin, Bingxian Yang, Bing-Nan Han, Lian-Hua Xu. (2022) The 16α-Hydroxylation of Progesterone by Cytochrome P450 107X1 from Streptomyces avermitilis. CHEMISTRY & BIODIVERSITY, 19 (5): (e202200177). [PMID:35426465] [10.1002/cbdv.202200177] |
16. Gang Zhai, Tingting Shu, Guangqing Yu, Haipei Tang, Chuang Shi, Jingyi Jia, Qiyong Lou, Xiangyan Dai, Xia Jin, Jiangyan He, Wuhan Xiao, Xiaochun Liu, Zhan Yin. (2022) Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling. eLife, [PMID:35225789] [10.7554/eLife.66118] |
17. Cui Hanyue, Lu Huan, Yang Jing, Fu Yao, Huang Yan, Li Li, Ding Yaping. (2022) A Significant Fluorescent Aptamer Sensor Based on Carbon Dots and Graphene Oxide for Highly Selective Detection of Progesterone. JOURNAL OF FLUORESCENCE, 32 (3): (927-936). [PMID:35119576] [10.1007/s10895-022-02896-4] |
18. Yan Wu, Kaixing Luo, Yanjuan Liu, Wei Chen, Zhengwu Bai, Sheng Tang. (2022) Innovative preparation of ureido/dodecyl dual-functionalized silica as a versatile mixed-mode stationary phase for high-resolution chromatographic separations. JOURNAL OF CHROMATOGRAPHY A, 1665 (462834). [PMID:35085896] [10.1016/j.chroma.2022.462834] |
19. Chenhong Yu, Li Li, Yaping Ding, Huajie Liu, Hanyue Cui. (2022) Molecularly imprinted electrochemical aptasensor based on functionalized graphene and nitrogen-doped carbon quantum dots for trace cortisol assay. ANALYST, 147 (4): (744-752). [PMID:35103724] [10.1039/D1AN01838H] |
20. Yi Zhang, Jie Zhou, Xiao-Xiao Zhang, Wen-Long Wang, Cheng Yang, Xueli Shi, Yong-Wei Feng, Renagul Abdurahman. (2022) NIR persistent luminescence nanoparticles based turn-on aptasensor for autofluorescence-free determination of 17β-estradiol in milk. FOOD CHEMISTRY, 373 (131432). [PMID:34717086] [10.1016/j.foodchem.2021.131432] |
21. Huiyi Yang, Qiyi He, Junkang Pan, Mingxia Lin, Zhiting Lao, Qinglan Li, Xiping Cui, Suqing Zhao. (2022) PtCu nanocages with superior tetra-enzyme mimics for colorimetric sensing and fluorescent sensing dehydroepiandrosterone. SENSORS AND ACTUATORS B-CHEMICAL, 351 (130905). [PMID:] [10.1016/j.snb.2021.130905] |
22. Minghui Zan, Shuai An, Lei Cao, Yulu Liu, Li Li, Mingfeng Ge, Pai Liu, Zaihui Wu, Wen-Fei Dong, Qian Mei. (2021) One-pot facile synthesis of yellow-green emission carbon dots for rapid and efficient determination of progesterone. APPLIED SURFACE SCIENCE, 566 (150686). [PMID:] [10.1016/j.apsusc.2021.150686] |
23. Yang Huiyi, He Qiyi, Eremin Sergei A., Pan Junkang, Zou Yikui, Cui Xiping, Zhao Suqing. (2021) Fluorescence polarization immunoassay for rapid determination of dehydroepiandrosterone in human urine. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413 (17): (4459-4469). [PMID:34137913] [10.1007/s00216-021-03403-7] |
24. Yongni Shao, Yutian Wang, Zhi Zhu, Jialing Liu, Xin Xiong, Yiming Zhu, Ruoqing Zhai, Ming Gu, Zhengan Tian, Yan Peng. (2021) Quantification Analysis of Progesterone Based on Terahertz Spectroscopy. IEEE Transactions on Terahertz Science and Technology, 11 (5): (519-526). [PMID:] [10.1109/TTHZ.2021.3082286] |
25. Yu-Ning Hu, Jin-Tao Zhan, Quan-Fei Zhu, Ting Hu, Na An, Zhen Zhou, Yong Liang, Wei Wang, Zhi Han, Jie Wang, Fu-Qiang Xu, Yu-Qi Feng. (2021) A mathematical method for calibrating the signal drift in liquid chromatography - mass spectrometry analysis. TALANTA, 233 (122511). [PMID:34215126] [10.1016/j.talanta.2021.122511] |
26. Shunyao Li, Kai Sun, Xin Yan, Chao Lu, Michael Gatheru Waigi, Juan Liu, Wanting Ling. (2021) Identification of novel catabolic genes involved in 17β-estradiol degradation by Novosphingobium sp. ES2-1. ENVIRONMENTAL MICROBIOLOGY, 23 (5): (2550-2563). [PMID:33754450] [10.1111/1462-2920.15475] |
27. Chaoqiang Pan, Jianmin Qiu, Lumei Wang, Zhiyu Yan, Weiwen Huang, Dongwei Zhang, Xuejia Zhan, Guoqing Shen, Chaoqiang Pan, Jianmin Qiu, Lumei Wang, Zhiyu Yan, Weiwen Huang, Dongwei Zhang, Xuejia Zhan, Guoqing Shen. (2020) Colorimetric Aptasensor for Testosterone Detection Based on Aggregation of Gold Nanoparticles Induced by Cationic Surfactant. AUSTRALIAN JOURNAL OF CHEMISTRY, 74 (4): (261-267). [PMID:] [10.1071/CH20237] |
28. Weiwen Huang, Yichen Wang, Lumei Wang, Chaoqiang Pan, Guoqing Shen. (2021) Colorimetric detection of ciprofloxacin in aqueous solution based on an unmodified aptamer and the aggregation of gold nanoparticles. Analytical Methods, 13 (1): (90-98). [PMID:33300899] [10.1039/D0AY01811B] |
29. Yang Huiyi, He Qiyi, Chen Yingshan, Shen Ding, Xiao Huanxin, Eremin Sergei A., Cui Xiping, Zhao Suqing. (2020) Platinum nanoflowers with peroxidase-like property in a dual immunoassay for dehydroepiandrosterone. MICROCHIMICA ACTA, 187 (11): (1-12). [PMID:33025211] [10.1007/s00604-020-04528-9] |
30. Zhu Jialei, Tang Jing. (2020) LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression. BIOSCIENCE REPORTS, 40 (8): [PMID:32706026] [10.1042/BSR20200672] |
31. Chunyang Guo, Qi Zhang, Bingqing Zhu, Zaiyong Zhang, Xiaoyu Ma, Wenjuan Dai, Xiaoyi Gong, Guobin Ren, Xuefeng Mei. (2020) Drug–Drug Cocrystals Provide Significant Improvements of Drug Properties in Treatment with Progesterone. CRYSTAL GROWTH & DESIGN, 20 (5): (3053–3063). [PMID:] [10.1021/acs.cgd.9b01688] |
32. Bai Ya-Li, Hong Zhi-Dan, Zhang Tian-Yi, Cai Bao-Dong, Zhang Yuan-Zhen, Feng Yu-Qi. (2020) A Method for Simultaneous Determination of 14 Carbonyl-Steroid Hormones in Human Serum by Ultra High Performance Liquid Chromatography–Tandem Mass Spectrometry. Journal of Analysis and Testing, 4 (1): (1-12). [PMID:] [10.1007/s41664-020-00120-5] |
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34. Yike Huang, Gaoyi Yi, Baian Ji, Die Gao, Yuntian Bai, Yao Liu, Lujun Wang, Zhining Xia, Qifeng Fu. (2020) In situ one-pot synthesis of polydopamine/octadecylamine co-deposited coating in capillary for open-tubular capillary electrochromatography. JOURNAL OF CHROMATOGRAPHY A, 1610 (460559). [PMID:31564563] [10.1016/j.chroma.2019.460559] |
35. Dingding Duan, Xiaojing Si, Yaping Ding, Li Li, Guohong Ma, Lu Zhang, Bingyu Jian. (2019) A novel molecularly imprinted electrochemical sensor based on double sensitization by MOF/CNTs and Prussian blue for detection of 17β-estradiol. BIOELECTROCHEMISTRY, 129 (211). [PMID:31200251] [10.1016/j.bioelechem.2019.04.014] |
36. Guihua Gao, Yanyan Xing, Tingting Liu, Jian Wang, Xiaohong Hou. (2019) UiO-66(Zr) as sorbent for porous membrane protected micro-solid-phase extraction androgens and progestogens in environmental water samples coupled with LC-MS/MS analysis: The application of experimental and molecular simulation method. MICROCHEMICAL JOURNAL, 146 (126). [PMID:] [10.1016/j.microc.2018.12.050] |
37. Yu Zong, Jia Chen, Jinxuan Hou, Wenwen Deng, Xiaoyan Liao, Yuxiu Xiao. (2018) Hexafluoroisopropanol-alkyl carboxylic acid high-density supramolecular solvent based dispersive liquid-liquid microextraction of steroid sex hormones in human urine. JOURNAL OF CHROMATOGRAPHY A, 1580 (12). [PMID:30391035] [10.1016/j.chroma.2018.10.041] |
38. Guotao Chen, Jianhuai Chen, Baibing Yang, Wen Yu, Yun Chen, Yutian Dai. (2018) Dopamine D2 receptors in the basolateral amygdala modulate erectile function in a rat model of nonorganic erectile dysfunction. ANDROLOGIA, 51 (1): (e13160). [PMID:30276840] [10.1111/and.13160] |
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40. Song Yuhong, Ma Ruiyang, Jiao Caina, Hao Lin, Wang Chun, Wu Qiuhua, Wang Zhi. (2018) Magnetic mesoporous polymelamine-formaldehyde resin as an adsorbent for endocrine disrupting chemicals. MICROCHIMICA ACTA, 185 (1): (1-8). [PMID:29594534] [10.1007/s00604-017-2593-5] |
41. Juanjuan Wu, Ruiyang Ma, Lin Hao, Chun Wang, Qiuhua Wu, Zhi Wang. (2017) Triphenylamine-based hypercrosslinked organic polymer as adsorbent for the extraction of phenylurea herbicides. JOURNAL OF CHROMATOGRAPHY A, 1520 (48). [PMID:28903856] [10.1016/j.chroma.2017.09.012] |
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