Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P276608-100mg | 100mg | In stock | $9.90 | |
P276608-250mg | 250mg | In stock | $16.90 | |
P276608-1g | 1g | In stock | $29.90 | |
P276608-5g | 5g | In stock | $45.90 | |
P276608-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $159.90 | |
P276608-100g | 100g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $452.90 |
Endogenous progesterone receptor agonist
Synonyms | Progestron | Progestone | Progestin | Pregnenedione | Prometrium | Corlutin | 4-Pregnene-3,20-dione | Syngesterone | Crinone | Glanducorpin | Hormoflaveine | Progesteronum | Progesterol | Agolutin | Luteol | Gestormone | Pregn-4-ene-3,20-dione | Utrogesta |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Endogenous progesterone receptor agonist (EC 50 = 0.5 nM) C-21 steroid hormone. Elicits a variety of biological effects. |
Storage Temp | Store at 2-8°C,Desiccated |
Shipped In | Wet ice |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy. |
ALogP | 3.9 |
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IUPAC Name | (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
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INCHI | InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 |
InChi Key | RJKFOVLPORLFTN-LEKSSAKUSA-N |
Canonical SMILES | CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C |
Isomeric SMILES | CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C |
WGK Germany | 3 |
RTECS | TW0175000 |
PubChem CID | 5994 |
Molecular Weight | 314.47 |
Beilstein | 1915950 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2317041 | Certificate of Analysis | Sep 04, 2024 | P276608 |
G2422184 | Certificate of Analysis | Jun 15, 2024 | P276608 |
G2422183 | Certificate of Analysis | Jun 15, 2024 | P276608 |
G2422182 | Certificate of Analysis | Jun 15, 2024 | P276608 |
G2422181 | Certificate of Analysis | Jun 15, 2024 | P276608 |
G2422180 | Certificate of Analysis | Jun 15, 2024 | P276608 |
A2411037 | Certificate of Analysis | Jan 20, 2024 | P276608 |
J2228136 | Certificate of Analysis | Aug 01, 2023 | P276608 |
G2107253 | Certificate of Analysis | Feb 10, 2023 | P276608 |
G2107254 | Certificate of Analysis | Feb 10, 2023 | P276608 |
G2107252 | Certificate of Analysis | Feb 10, 2023 | P276608 |
G2107250 | Certificate of Analysis | Feb 10, 2023 | P276608 |
G2107249 | Certificate of Analysis | Feb 10, 2023 | P276608 |
F2330034 | Certificate of Analysis | Feb 10, 2023 | P276608 |
E2312277 | Certificate of Analysis | Feb 10, 2023 | P276608 |
C2331037 | Certificate of Analysis | Feb 10, 2023 | P276608 |
B2209087 | Certificate of Analysis | Nov 15, 2022 | P276608 |
D2426102 | Certificate of Analysis | May 29, 2021 | P276608 |
Solubility | Soluble in DMSO to 100 mM and in ethanol to 100 mM |
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Sensitivity | Sensitive to light |
Specific Rotation[α] | 182 ° (C=2, Dioxane) |
Melt Point(°C) | 126-131°C |
Pictogram(s) | GHS08 |
---|---|
Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H360:May damage fertility or the unborn child H350:May cause cancer H361:Suspected of damaging fertility or the unborn child H362:May cause harm to breast-fed children |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | TW0175000 |
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1. Juan Luo, Bowen Zhou, Chenjun Dong, Rongrong He, Yuling Zhang, Tao He. (2024) Effect of substrate morphology on characteristics of layer-by-layer self-assembly nanofiltration membrane for micropollutants removal. DESALINATION, 574 (117229). [PMID:] |
2. Zu Qiang Jiang, Lei Zhang, Cui Juan Lan, Jian Ping Wang. (2023) Development of a Progesterone-Receptor-Based Pseudo-immunoassay for Multi-detection of Progestins in Milk and Studying Its Recognition Mechanism. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:37938156] |
3. Yan Su, Gelin Liu, Haozhe Hou, Yaojia Peng, Jianping Wang. (2023) Development of a Magnetic Molecularly Imprinted Microsphere-Based Signal Amplified Semi-Homogeneous Method for Multidetection of Five Progestins in Milk. Foods, 12 (15): (2818). [PMID:37569089] |
4. Xu Yang-ding, Guo Yu-jie, Mao He-rong, Xiong Zhi-xiang, Luo Meng-yu, Luo Rui-qi, Lu Shan, Huang Lu, Hong Yi. (2023) Integration of transcriptomics and proteomics to elucidate inhibitory effect and mechanism of rosmarinic acid from Perilla frutescens (L.) Britt. in treating Trichophyton mentagrophytes. Chinese Medicine, 18 (1): (1-20). [PMID:37280712] |
5. Jing Yang, Hao Liu, Yan Huang, Li Li, Xiaoli Zhu, Yaping Ding. (2023) One-step hydrothermal synthesis of near-infrared emission carbon quantum dots as fluorescence aptamer sensor for cortisol sensing and imaging. TALANTA, 260 (124637). [PMID:37172433] |
6. Haoyu Long, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks. TALANTA, 260 (124589). [PMID:37126925] |
7. Zhefei Hu, Yanhao Jiang, Panpan Cao, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Performance evaluation of 2-undecylimidazole/propyl methacrylate bifunctional silica gel for mixed-mode reversed-phase/anion-exchange chromatography. MICROCHEMICAL JOURNAL, 191 (108768). [PMID:] |
8. Jiameng Liu, Mengfei Wang, Chuanpan Guo, Zheng Tao, Minghua Wang, Linghao He, Baozhong Liu, Zhihong Zhang. (2023) Defective porphyrin-based metal-organic framework nanosheets derived from V2CTx MXene as a robust bioplatform for impedimetric aptasensing 17β-estradiol. FOOD CHEMISTRY, 416 (135839). [PMID:36893636] |
9. Ling Wang, Xiaowei Wu, Chenghua Gao, Lingrui Wei, Qian Li, Aitao Li. (2023) A Fungal P450 Enzyme from Fusarium graminearum with Unique 12β-Steroid Hydroxylation Activity. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 89 (3): [PMID:36853033] |
10. Nanjun Li, Chongyang Wang, Liangjun Chen, Cui Ye, Yongwu Peng. (2022) Ultrathin Covalent Organic Framework Nanosheets/Ti3C2Tx-Based Photoelectrochemical Biosensor for Efficient Detection of Prostate-Specific Antigen. MOLECULES, 27 (19): (6732). [PMID:36235265] |
11. Yajiao Zhang, Minjie Liu, Huijing Wang, Juan Lin, Fener Chen. (2022) Focused mutagenesis in non-catalytic cavity for improving catalytic efficiency of 3-ketosteroid-Δ1-dehydrogenase. Molecular Catalysis, 531 (112661). [PMID:] |
12. Wenjing Wang, Fei Zhai, Fupei Xu, Min Jia. (2022) Enzyme-free amplified and one-step rapid detection of bisphenol A using dual-terminal labeled split aptamer probes. MICROCHEMICAL JOURNAL, 183 (107977). [PMID:] |
13. Yan Wu, Panpan Cao, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Zhengwu Bai, Sheng Tang. (2022) Ingenious introduction of aminopropylimidazole to tune the hydrophobic selectivity of dodecyl-bonded stationary phase for environmental organic pollutants. MICROCHEMICAL JOURNAL, 182 (107933). [PMID:] |
14. Huiyi Yang, Qiyi He, Mingxia Lin, Li Ji, Leheng Zhang, Huanxin Xiao, Shijia Li, Qinglan Li, Xiping Cui, Suqing Zhao. (2022) Multifunctional Au@Pt@Ag NPs with color-photothermal-Raman properties for multimodal lateral flow immunoassay. JOURNAL OF HAZARDOUS MATERIALS, 435 (129082). [PMID:35650752] |
15. Susu Lin, Bingbing Ma, Qilin Gao, Jian Yang, Gang Lai, Runhao Lin, Bingxian Yang, Bing-Nan Han, Lian-Hua Xu. (2022) The 16α-Hydroxylation of Progesterone by Cytochrome P450 107X1 from Streptomyces avermitilis. CHEMISTRY & BIODIVERSITY, 19 (5): (e202200177). [PMID:35426465] |
16. Gang Zhai, Tingting Shu, Guangqing Yu, Haipei Tang, Chuang Shi, Jingyi Jia, Qiyong Lou, Xiangyan Dai, Xia Jin, Jiangyan He, Wuhan Xiao, Xiaochun Liu, Zhan Yin. (2022) Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling. eLife, [PMID:35225789] |
17. Cui Hanyue, Lu Huan, Yang Jing, Fu Yao, Huang Yan, Li Li, Ding Yaping. (2022) A Significant Fluorescent Aptamer Sensor Based on Carbon Dots and Graphene Oxide for Highly Selective Detection of Progesterone. JOURNAL OF FLUORESCENCE, 32 (3): (927-936). [PMID:35119576] |
18. Yan Wu, Kaixing Luo, Yanjuan Liu, Wei Chen, Zhengwu Bai, Sheng Tang. (2022) Innovative preparation of ureido/dodecyl dual-functionalized silica as a versatile mixed-mode stationary phase for high-resolution chromatographic separations. JOURNAL OF CHROMATOGRAPHY A, 1665 (462834). [PMID:35085896] |
19. Chenhong Yu, Li Li, Yaping Ding, Huajie Liu, Hanyue Cui. (2022) Molecularly imprinted electrochemical aptasensor based on functionalized graphene and nitrogen-doped carbon quantum dots for trace cortisol assay. ANALYST, 147 (4): (744-752). [PMID:35103724] |
20. Yi Zhang, Jie Zhou, Xiao-Xiao Zhang, Wen-Long Wang, Cheng Yang, Xueli Shi, Yong-Wei Feng, Renagul Abdurahman. (2022) NIR persistent luminescence nanoparticles based turn-on aptasensor for autofluorescence-free determination of 17β-estradiol in milk. FOOD CHEMISTRY, 373 (131432). [PMID:34717086] |
21. Huiyi Yang, Qiyi He, Junkang Pan, Mingxia Lin, Zhiting Lao, Qinglan Li, Xiping Cui, Suqing Zhao. (2022) PtCu nanocages with superior tetra-enzyme mimics for colorimetric sensing and fluorescent sensing dehydroepiandrosterone. SENSORS AND ACTUATORS B-CHEMICAL, 351 (130905). [PMID:] |
22. Qingwen Zhang,Lijing Jing,Jinling Zhang,Yamin Ren,Yang Wang,Yi Wang,Tianxin Wei,Bo Liedberg. (2014-07-06) Surface plasmon resonance sensor for femtomolar detection of testosterone with water-compatible macroporous molecularly imprinted film.. Analytical biochemistry, 463 (7-14). [PMID:24991687] |
1. Juan Luo, Bowen Zhou, Chenjun Dong, Rongrong He, Yuling Zhang, Tao He. (2024) Effect of substrate morphology on characteristics of layer-by-layer self-assembly nanofiltration membrane for micropollutants removal. DESALINATION, 574 (117229). [PMID:] |
2. Zu Qiang Jiang, Lei Zhang, Cui Juan Lan, Jian Ping Wang. (2023) Development of a Progesterone-Receptor-Based Pseudo-immunoassay for Multi-detection of Progestins in Milk and Studying Its Recognition Mechanism. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:37938156] |
3. Yan Su, Gelin Liu, Haozhe Hou, Yaojia Peng, Jianping Wang. (2023) Development of a Magnetic Molecularly Imprinted Microsphere-Based Signal Amplified Semi-Homogeneous Method for Multidetection of Five Progestins in Milk. Foods, 12 (15): (2818). [PMID:37569089] |
4. Xu Yang-ding, Guo Yu-jie, Mao He-rong, Xiong Zhi-xiang, Luo Meng-yu, Luo Rui-qi, Lu Shan, Huang Lu, Hong Yi. (2023) Integration of transcriptomics and proteomics to elucidate inhibitory effect and mechanism of rosmarinic acid from Perilla frutescens (L.) Britt. in treating Trichophyton mentagrophytes. Chinese Medicine, 18 (1): (1-20). [PMID:37280712] |
5. Jing Yang, Hao Liu, Yan Huang, Li Li, Xiaoli Zhu, Yaping Ding. (2023) One-step hydrothermal synthesis of near-infrared emission carbon quantum dots as fluorescence aptamer sensor for cortisol sensing and imaging. TALANTA, 260 (124637). [PMID:37172433] |
6. Haoyu Long, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks. TALANTA, 260 (124589). [PMID:37126925] |
7. Zhefei Hu, Yanhao Jiang, Panpan Cao, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Performance evaluation of 2-undecylimidazole/propyl methacrylate bifunctional silica gel for mixed-mode reversed-phase/anion-exchange chromatography. MICROCHEMICAL JOURNAL, 191 (108768). [PMID:] |
8. Jiameng Liu, Mengfei Wang, Chuanpan Guo, Zheng Tao, Minghua Wang, Linghao He, Baozhong Liu, Zhihong Zhang. (2023) Defective porphyrin-based metal-organic framework nanosheets derived from V2CTx MXene as a robust bioplatform for impedimetric aptasensing 17β-estradiol. FOOD CHEMISTRY, 416 (135839). [PMID:36893636] |
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