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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P275413-1mg | 1mg | In stock | $276.90 | |
P275413-500μg | 500μg | In stock | $166.90 |
PKC activator; reactivates HIV-1 latency
Synonyms | (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one | NSC 623310; SA 101A; Stillingia factor S7 | Q3270742 | C20197 | CHEBI:69818 | |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | PKC activator; Through NF relying on PKC- κ B activates and reactivates HIV-1 latency (IC 50=〜 0.5 µ M). Down-regulate the expression of HIV-1 receptor CD4 and its co-receptors CXCR4 and CCR5 in vitro. Non-tumor promotion. Prostratin is an uncommon non-ca |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C (desiccating conditions). |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [(1R,2S,6R,10S,11R,13S,15R)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-13-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] acetate |
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INCHI | InChI=1S/C22H30O6/c1-11-6-16-20(26,18(11)25)9-14(10-23)7-15-17-19(4,5)21(17,28-13(3)24)8-12(2)22(15,16)27/h6-7,12,15-17,23,26-27H,8-10H2,1-5H3/t12-,15+,16-,17-,20-,21+,22-/m1/s1 |
InChi Key | BOJKFRKNLSCGHY-HXGSDTCMSA-N |
Canonical SMILES | CC1CC2(C(C2(C)C)C3C1(C4C=C(C(=O)C4(CC(=C3)CO)O)C)O)OC(=O)C |
Isomeric SMILES | C[C@@H]1C[C@@]2([C@@H](C2(C)C)[C@H]3[C@]1([C@@H]4C=C(C(=O)[C@]4(CC(=C3)CO)O)C)O)OC(=O)C |
PubChem CID | 454217 |
Molecular Weight | 390.48 |
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Solubility | Supplied in ethanol (at lot-dependent concentrations). Soluble in ethanol to 10 mg/ml.DMF: 10 mg/ml;DMSO: 10 mg/ml |
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1. Li T et al.. (2022) Growth factors-based platelet lysate rejuvenates skin against ageing through NF-κB signalling pathway: In vitro and in vivo mechanistic and clinical studies.. Cell Prolif, 55 (4): (e13212). [PMID:35274780] |