PROTAC FAK degrader 1 - 99%, high purity , CAS No.2301916-69-6

Item Number

P651902

Grouped product items
SKU	Size	Availability	Price
P651902-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,500.90
P651902-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$550.90
P651902-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$980.90

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Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	PROTAC FAK degrader 1 is a selective and potent von Hippel-Lindau -based focal adhesion kinase ( FAK ) degrader with an IC 50 of 6.5 nM, DC 50 of 3 nM.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Product Description	PROTAC FAK degrader 1 is a selective and potent von Hippel-Lindau -based focal adhesion kinase ( FAK ) degrader with an IC 50 of 6.5 nM, DC 50 of 3 nM Form:Solid IC50& Target:IC50: 6.5 nM (Focal adhesion kinase) DC50: 3 nM (Focal adhesion kinase)

Associated Targets(Human)

PTK2 Tclin Focal adhesion kinase 1 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTK2 Tclin Focal adhesion kinase 1 (4730 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S,4R)-1-[(2S)-3,3-dimethyl-2-[3-[2-[4-[[4-[[3-[methyl(methylsulfonyl)amino]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenoxy]ethoxy]propanoylamino]butanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
INCHI	InChI=1S/C47H56F3N9O8S2/c1-29-40(68-28-54-29)32-12-10-30(11-13-32)24-52-43(62)38-23-35(60)27-59(38)44(63)41(46(2,3)4)56-39(61)18-19-66-20-21-67-36-16-14-33(15-17-36)55-45-53-26-37(47(48,49)50)42(57-45)51-25-31-8-7-9-34(22-31)58(5)69(6,64)65/h7-17,22,26,28,35,38,41,60H,18-21,23-25,27H2,1-6H3,(H,52,62)(H,56,61)(H2,51,53,55,57)/t35-,38+,41-/m1/s1
InChi Key	MVULIYLBRNHLEE-LFHXYJAASA-N
Canonical SMILES	CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCOC4=CC=C(C=C4)NC5=NC=C(C(=N5)NCC6=CC(=CC=C6)N(C)S(=O)(=O)C)C(F)(F)F)O
Isomeric SMILES	CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCOCCOC4=CC=C(C=C4)NC5=NC=C(C(=N5)NCC6=CC(=CC=C6)N(C)S(=O)(=O)C)C(F)(F)F)O
PubChem CID	138454773
Molecular Weight	996.13

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Basic Description