Proteasome Inhibitor VII, Antiprotealide is a cell-permeable, Omuralide-Salinosporamide hybrid that irreversibly inactivates the β5-subunit of the human 20S proteasome. The compound has shown to be ~2.5-fold more potent than Omuralide and is expected to exhibit comparable whole cell potency to Salinosporamide A. Proteasome Inhibitor VII, Antiprotealideis which inactivates the β5-subunit of the human 20S proteasome