Bmi1/Ring1A inhibitor (IC 50 = 3.9 μM). Prevents ubiquitination and drug-induced degradation of topoisomerase. Blocks PRC1-mediated histone H2A ubiquitination in vivo.
Storage Temp
Store at -20°C
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Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Zhang Y et al.. (2020) H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death.. Cancer Res, 80 (11):(2243-2256). [PMID:32273282]
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G2203403