Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P288663-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $103.90 | |
P288663-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $158.90 | |
P288663-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $356.90 | |
P288663-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $677.90 |
Selective human A2Bantagonist; water-soluble
Synonyms | CHEBI:92848 | GTPL3286 | compound 17 [PMID: 11906291] | EX-A7843 | AKOS024456909 | SCHEMBL1223271 | SR-01000597529-1 | Q27088472 | PSB 1115 | HMS3677C03 | PSB1115 | PSB-1115 | BRD-K49027941-237-01-1 | NCGC00025344-01 | DTXSID80415532 | Tocris-2009 | BDBM5 |
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Specifications & Purity | Moligand™, ≥95% |
Biochemical and Physiological Mechanisms | Highly selective, water-soluble, human A2Badenosine receptor antagonist. Kivalues are 53.4, > 10000 and > 10000 nM at human A2B, A1and A3receptors respectively. Also selective versus rat A1and A2Areceptors (Kivalues are 2200 and 24000 nM respectively). Pr |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of A 1 receptor;Antagonist of A 2A receptor;Antagonist of A 2B receptor;Antagonist of A 3 receptor |
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IUPAC Name | 4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)benzenesulfonic acid |
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INCHI | InChI=1S/C14H14N4O5S/c1-2-7-18-13(19)10-12(17-14(18)20)16-11(15-10)8-3-5-9(6-4-8)24(21,22)23/h3-6H,2,7H2,1H3,(H,15,16)(H,17,20)(H,21,22,23) |
InChi Key | UYDRRQPGDSIMNU-UHFFFAOYSA-N |
Canonical SMILES | CCCN1C(=O)C2=C(NC1=O)N=C(N2)C3=CC=C(C=C3)S(=O)(=O)O |
Isomeric SMILES | CCCN1C(=O)C2=C(NC1=O)N=C(N2)C3=CC=C(C=C3)S(=O)(=O)O |
PubChem CID | 5311479 |
Molecular Weight | 350.35 |
CAS Registry No. | 152529-79-8 |
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PubChem CID | 5311479 |
ChEMBL Ligand | CHEMBL8565 |
GPCRdb Ligand | PSB1115 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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B2427032 | Certificate of Analysis | Jan 20, 2024 | P288663 |
B2427033 | Certificate of Analysis | Jan 20, 2024 | P288663 |
B2427034 | Certificate of Analysis | Jan 20, 2024 | P288663 |
B2427035 | Certificate of Analysis | Jan 20, 2024 | P288663 |
B2427036 | Certificate of Analysis | Jan 20, 2024 | P288663 |
B2427037 | Certificate of Analysis | Jan 20, 2024 | P288663 |
B2427038 | Certificate of Analysis | Jan 20, 2024 | P288663 |
B2427039 | Certificate of Analysis | Jan 20, 2024 | P288663 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 38.84, Max Conc. mM: 100; Solvent:water, Max Conc. mg/mL: 7.77, Max Conc. mM: 20 with gentle warming |
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1. Hayallah AM, Sandoval-Ramírez J, Reith U, Schobert U, Preiss B, Schumacher B, Daly JW, Müller CE. (2002) 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.. J Med Chem, 45 (7): (1500-10). [PMID:11906291] |