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PSB-12062 - 99%, high purity , CAS No.55476-47-6
Basic Description Synonyms Oprea1_008733 | PSB-12062 | CS-6918 | N-(p-Methylphenylsulfonyl)phenoxazineN-(p-Methylphenylsulfonyl)phenoxazine | 10-tosyl-10H-phenoxazine | GTPL9542 | AKOS027422597 | 10H-Phenoxazine, 10-[(4-methylphenyl)sulfonyl]- | EX-A7266 | 10-(4-methylphenyl)sulfon Specifications & Purity ≥99% Biochemical and Physiological Mechanisms PSB-12062 is a potent and selective P2X4 antagonist with an IC 50 of 1.38 μM for human P2X4. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description PSB-12062 is a potent and selective P2X4 antagonist with an IC 50 of 1.38 μM for human P2X4.
In Vitro
PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4)
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 10-(4-methylphenyl)sulfonylphenoxazine INCHI InChI=1S/C19H15NO3S/c1-14-10-12-15(13-11-14)24(21,22)20-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)20/h2-13H,1H3 InChi Key DHZNMEIBMACSFH-UHFFFAOYSA-N Canonical SMILES CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3OC4=CC=CC=C42 Isomeric SMILES CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3OC4=CC=CC=C42 WGK Germany 3 PubChem CID 2320735 Molecular Weight 337.39
Chemical and Physical Properties Solubility DMSO : 25 mg/mL (74.10 mM; Need ultrasonic)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
WGK Germany 3 RIDADR NONHforallmodesoftransport
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