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Orphan and other 7TM receptors
G protein-coupled receptors (GPCRs)
PSB-1584 , CAS No.P612988, Agonist of GPR84

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PSB-1584 , CAS No.P612988, Agonist of GPR84

Moligand™

PubChem CID: 44349321

Item Number

P612988

Grouped product items
SKU	Size	Availability	Price	Qty
P612988-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$922.90
P612988-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,226.90

View related series

GPR84 Agonist

Basic Description

Synonyms	6-hexylaminouracil;compound 20;PSB1584
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of GPR84

Associated Targets(Human)

GPR84 Tchem G-protein coupled receptor 84 (3 Activities)

Discover Target: GPR84

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

topB DNA topoisomerase III (145 Activities)

Discover Target: topB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	6-(hexylamino)-1H-pyrimidine-2,4-dione
INCHI	InChI=1S/C10H17N3O2/c1-2-3-4-5-6-11-8-7-9(14)13-10(15)12-8/h7H,2-6H2,1H3,(H3,11,12,13,14,15)
InChi Key	SDXQSUJXSHUIBQ-UHFFFAOYSA-N
Canonical SMILES	CCCCCCNc1cc(=O)[nH]c(=O)[nH]1
Isomeric SMILES	CCCCCCNC1=CC(=O)NC(=O)N1
PubChem CID	44349321

Database links

PubChem CID	44349321
ChEMBL Ligand	CHEMBL124977
BindingDB Ligand	50028344
GPCRdb Ligand	PSB-1584

Certificates

Certificate of Analysis(COA)

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References

1. Pillaiyar T, Köse M, Namasivayam V, Sylvester K, Borges G, Thimm D, von Kügelgen I, Müller CE. (2018) 6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84).. ACS Omega, 3 (3): (3365-3383). [PMID:30023867] [10.1021/op500134e]
2. Köse M, Pillaiyar T, Namasivayam V, De Filippo E, Sylvester K, Ulven T, von Kügelgen I, Müller CE. (2020) An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights.. J Med Chem, 63 (5): (2391-2410). [PMID:31721581] [10.1021/acs.jmedchem.9b01339]

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