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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P275651-5mg | 5mg | In stock | $187.90 | |
P275651-25mg | 25mg | In stock | $846.90 | |
P275651-100mg | 100mg | In stock | $3,045.90 |
Potent and selective inhibitor of hypoxia inducible factor
Synonyms | MK3795 | MK-3795 | Q27456687 | (s)-3-((2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1h-inden-4-yl)oxy)-5-fluorobenzonitrile | s8352 | NCGC00387306-02 | B4285 | 1672665-49-4 | BDBM373008 | SCHEMBL16555810 | EX-A2855 | NSC787312 | NSC-787312 | 3-{[ |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Potent and selective inhibitor of hypoxia inducible factor (HIF-2α) with potential antineoplastic activity. PT-2385 selectively disrupts the heterodimerization of HIF-2α with HIF-1β. Very effective in blocking cancer cell growth, proliferation. |
Storage Temp | Protected from light,Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Shipped at Room Temperature. Store at -20°C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store In the Dark. Store under desiccating conditions. |
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IUPAC Name | 3-[[(1S)-2,2-difluoro-1-hydroxy-7-methylsulfonyl-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrile |
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INCHI | InChI=1S/C17H12F3NO4S/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11/h2-6,16,22H,7H2,1H3/t16-/m0/s1 |
InChi Key | ONBSHRSJOPSEGS-INIZCTEOSA-N |
Canonical SMILES | CS(=O)(=O)C1=C2C(C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O |
Isomeric SMILES | CS(=O)(=O)C1=C2[C@@H](C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O |
PubChem CID | 91754484 |
Molecular Weight | 383.34 |
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Solubility | DMSO |
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Sensitivity | air sensitive |