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PU 02 - ≥97%(HPLC), high purity , CAS No.313984-77-9
Negative allosteric modulator of 5-HT3receptors
Basic Description Synonyms 6-[(1-Naphthalenylmethyl)thio]-9H-purine Specifications & Purity ≥97%(HPLC) Biochemical and Physiological Mechanisms Negative allosteric modulator of 5-HT3receptors (IC50values are 0.36 and 0.73μM in HEK293 cells transfected with human 5-HT3Aand 5-HT3ABreceptors respectively). Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description product description：
PU02, a derivative of 6-MP, is a negative allosteric modulator (NAM) of 5-HT3 receptor with IC50 of 0.36 μM and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors, respectively.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 6-(naphthalen-1-ylmethylsulfanyl)-7H-purine INCHI InChI=1S/C16H12N4S/c1-2-7-13-11(4-1)5-3-6-12(13)8-21-16-14-15(18-9-17-14)19-10-20-16/h1-7,9-10H,8H2,(H,17,18,19,20) InChi Key BGMSTNYJYPSLHN-UHFFFAOYSA-N Canonical SMILES C1=CC=C2C(=C1)C=CC=C2CSC3=NC=NC4=C3NC=N4 Isomeric SMILES C1=CC=C2C(=C1)C=CC=C2CSC3=NC=NC4=C3NC=N4 PubChem CID 720937 Molecular Weight 292.36
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: None, Max Conc. mM: 100；Soluble in DMSO
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P301+P312: IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.
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B2209587