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PU-H71 - ≥98%, high purity , CAS No.873436-91-0
Basic Description Synonyms DivK1c_006639 | Oprea1_485666 | STR09510 | UNII-06IVK87M04 | PU-H71, d6 | HMS3653N04 | J-690375 | SB17115 | 06IVK87M04 | FT-0700388 | HY-11038 | PU-H 71 | STK400094 | CAS#873436-91-0 | 9H-Purine-9-propanamine, 6-amino-8-((6-iodo-1,3-benzodioxol-5-yl)thio) Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Potent inhibitor of heat shock protein 90 (Hsp90) (IC50= 51 nM in MDA-MB-468 cells). Also inhibits cell growth in a range of breast cancer cell lines (IC50values are 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells res Storage Temp Protected from light,Store at -20°C Shipped In Ice chest + Ice pads Product Description PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 8-[(6-iodo-1,3-benzodioxol-5-yl)sulfanyl]-9-[3-(propan-2-ylamino)propyl]purin-6-amine INCHI InChI=1S/C18H21IN6O2S/c1-10(2)21-4-3-5-25-17-15(16(20)22-8-23-17)24-18(25)28-14-7-13-12(6-11(14)19)26-9-27-13/h6-8,10,21H,3-5,9H2,1-2H3,(H2,20,22,23) InChi Key SUPVGFZUWFMATN-UHFFFAOYSA-N Canonical SMILES CC(C)NCCCN1C2=NC=NC(=C2N=C1SC3=C(C=C4C(=C3)OCO4)I)N Isomeric SMILES CC(C)NCCCN1C2=NC=NC(=C2N=C1SC3=C(C=C4C(=C3)OCO4)I)N PubChem CID 9549213 Molecular Weight 512.37
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 51.24, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 51.24, Max Conc. mM: 100 Sensitivity light sensitive
Citations of This Product 1. Li Peng, Bai Chujie, Zhan Lingmin, Zhang Haoran, Zhang Yuanyuan, Zhang Wuxia, Wang Yingdong, Zhao Jinzhong. (2023) Specific gene module pair-based target identification and drug discovery. Frontiers in Pharmacology, 13 [PMID:36726786 ] [10.3389/fphar.2022.1089217 ]
References 1. Li Peng, Bai Chujie, Zhan Lingmin, Zhang Haoran, Zhang Yuanyuan, Zhang Wuxia, Wang Yingdong, Zhao Jinzhong. (2023) Specific gene module pair-based target identification and drug discovery. Frontiers in Pharmacology, 13 [PMID:36726786 ] [10.3389/fphar.2022.1089217 ]
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