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PU-H71 - 10mM in DMSO, high purity , CAS No.873436-91-0
Basic Description Synonyms PU-H71 | 873436-91-0 | Zelavespib | PU-H 71 | PU H71 | PUH-71 | PU-H-71 | 8-((6-Iodobenzo[d][1,3]dioxol-5-yl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine | 6-amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-n-(1-methylethyl)-9h-purine-9-propanamine | 9H-Purine-9-propanam Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Potent inhibitor of heat shock protein 90 (Hsp90) (IC50= 51 nM in MDA-MB-468 cells). Also inhibits cell growth in a range of breast cancer cell lines (IC50values are 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells res Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 8-[(6-iodo-1,3-benzodioxol-5-yl)sulfanyl]-9-[3-(propan-2-ylamino)propyl]purin-6-amine INCHI InChI=1S/C18H21IN6O2S/c1-10(2)21-4-3-5-25-17-15(16(20)22-8-23-17)24-18(25)28-14-7-13-12(6-11(14)19)26-9-27-13/h6-8,10,21H,3-5,9H2,1-2H3,(H2,20,22,23) InChi Key SUPVGFZUWFMATN-UHFFFAOYSA-N Canonical SMILES CC(C)NCCCN1C2=NC=NC(=C2N=C1SC3=C(C=C4C(=C3)OCO4)I)N Isomeric SMILES CC(C)NCCCN1C2=NC=NC(=C2N=C1SC3=C(C=C4C(=C3)OCO4)I)N PubChem CID 9549213 Molecular Weight 512.37
Citations of This Product 1. Li Peng, Bai Chujie, Zhan Lingmin, Zhang Haoran, Zhang Yuanyuan, Zhang Wuxia, Wang Yingdong, Zhao Jinzhong. (2023) Specific gene module pair-based target identification and drug discovery. Frontiers in Pharmacology, 13 [PMID:36726786 ] [10.3389/fphar.2022.1089217 ]
References 1. Li Peng, Bai Chujie, Zhan Lingmin, Zhang Haoran, Zhang Yuanyuan, Zhang Wuxia, Wang Yingdong, Zhao Jinzhong. (2023) Specific gene module pair-based target identification and drug discovery. Frontiers in Pharmacology, 13 [PMID:36726786 ] [10.3389/fphar.2022.1089217 ]
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