Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P275897-5mg | 5mg | In stock | $345.90 | |
P275897-10mg | 10mg | In stock | $553.90 | |
P275897-25mg | 25mg | In stock | $1,246.90 | |
P275897-50mg | 50mg | In stock | $2,243.90 | |
P275897-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $4,038.90 |
Potent O-GlcNAcase, hexosaminidase A and B inhibitor
Synonyms | Pugnac | 132489-69-1 | (Z)-PugNAc | AWZ7VE64B6 | O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate | Nac-lapco | O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-Phenylcarbamate | (E)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-Phenylca |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | Potent O-GlcNAcase, hexosaminidase A and B inhibitor (IC 50 values are 6, 25, 35 and 46 nM for β-hexosaminidase, HeX A/B, hOGA and OGA respectively). Decreases GLUT4 translocation and insulin-stimulated 2-deoxyglucose uptake in adipocytes. |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store In the Dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. |
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IUPAC Name | [(Z)-[(3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-ylidene]amino] N-phenylcarbamate |
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INCHI | InChI=1S/C15H19N3O7/c1-8(20)16-11-13(22)12(21)10(7-19)24-14(11)18-25-15(23)17-9-5-3-2-4-6-9/h2-6,10-13,19,21-22H,7H2,1H3,(H,16,20)(H,17,23)/b18-14-/t10-,11-,12-,13-/m1/s1 |
InChi Key | PBLNJFVQMUMOJY-JXZOILRNSA-N |
Canonical SMILES | CC(=O)NC1C(C(C(OC1=NOC(=O)NC2=CC=CC=C2)CO)O)O |
Isomeric SMILES | CC(=O)N[C@@H]\1[C@H]([C@@H]([C@H](O/C1=N\OC(=O)NC2=CC=CC=C2)CO)O)O |
PubChem CID | 9576811 |
Molecular Weight | 353.33 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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J2318379 | Certificate of Analysis | Aug 19, 2024 | P275897 |
J2318380 | Certificate of Analysis | Aug 19, 2024 | P275897 |
J2318381 | Certificate of Analysis | Aug 19, 2024 | P275897 |
J2318382 | Certificate of Analysis | Aug 19, 2024 | P275897 |
J2318383 | Certificate of Analysis | Aug 19, 2024 | P275897 |
J2318375 | Certificate of Analysis | Aug 15, 2024 | P275897 |
J2318376 | Certificate of Analysis | Aug 15, 2024 | P275897 |
J2318377 | Certificate of Analysis | Aug 15, 2024 | P275897 |
J2318378 | Certificate of Analysis | Aug 15, 2024 | P275897 |
J2318372 | Certificate of Analysis | Oct 07, 2023 | P275897 |
J2318373 | Certificate of Analysis | Oct 07, 2023 | P275897 |
J2319377 | Certificate of Analysis | Oct 07, 2023 | P275897 |
J2319381 | Certificate of Analysis | Oct 07, 2023 | P275897 |
Solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly), Water (Slightly) |
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Sensitivity | Air & Light & Heat & Moisture sensitive |
1. Latorre-Muro P et al.. (2021) A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation.. Cell Metab, 33 (3): (598-614.e7). [PMID:33592173] |
2. He X et al.. (2022) O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction.. Cell Death Differ, 29 (10): (1970-1981). [PMID:35422493] |