PugNAc - 95%, high purity , CAS No.132489-69-1

  • ≥95%
Item Number
P275897
Grouped product items
SKUSizeAvailabilityPrice Qty
P275897-5mg
5mg
In stock
$345.90
P275897-10mg
10mg
In stock
$553.90
P275897-25mg
25mg
In stock
$1,246.90
P275897-50mg
50mg
In stock
$2,243.90
P275897-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$4,038.90

Potent O-GlcNAcase, hexosaminidase A and B inhibitor

Basic Description

SynonymsPugnac | 132489-69-1 | (Z)-PugNAc | AWZ7VE64B6 | O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate | Nac-lapco | O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-Phenylcarbamate | (E)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-Phenylca
Specifications & Purity≥95%
Biochemical and Physiological MechanismsPotent O-GlcNAcase, hexosaminidase A and B inhibitor (IC 50 values are 6, 25, 35 and 46 nM for β-hexosaminidase, HeX A/B, hOGA and OGA respectively). Decreases GLUT4 translocation and insulin-stimulated 2-deoxyglucose uptake in adipocytes.
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store In the Dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.

Associated Targets(Human)

OGA Tchem Protein O-GlcNAcase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NAGPA Tbio N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (10 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OGA Tchem Bifunctional protein NCOAT (460 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

nagZ Beta-hexosaminidase (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Oga Protein O-GlcNAcase (31 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name [(Z)-[(3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-ylidene]amino] N-phenylcarbamate
INCHI InChI=1S/C15H19N3O7/c1-8(20)16-11-13(22)12(21)10(7-19)24-14(11)18-25-15(23)17-9-5-3-2-4-6-9/h2-6,10-13,19,21-22H,7H2,1H3,(H,16,20)(H,17,23)/b18-14-/t10-,11-,12-,13-/m1/s1
InChi Key PBLNJFVQMUMOJY-JXZOILRNSA-N
Canonical SMILES CC(=O)NC1C(C(C(OC1=NOC(=O)NC2=CC=CC=C2)CO)O)O
Isomeric SMILES CC(=O)N[C@@H]\1[C@H]([C@@H]([C@H](O/C1=N\OC(=O)NC2=CC=CC=C2)CO)O)O
PubChem CID 9576811
Molecular Weight 353.33

Certificates

Certificate of Analysis(COA)

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13 results found

Lot NumberCertificate TypeDateItem
J2318379Certificate of AnalysisAug 19, 2024 P275897
J2318380Certificate of AnalysisAug 19, 2024 P275897
J2318381Certificate of AnalysisAug 19, 2024 P275897
J2318382Certificate of AnalysisAug 19, 2024 P275897
J2318383Certificate of AnalysisAug 19, 2024 P275897
J2318375Certificate of AnalysisAug 15, 2024 P275897
J2318376Certificate of AnalysisAug 15, 2024 P275897
J2318377Certificate of AnalysisAug 15, 2024 P275897
J2318378Certificate of AnalysisAug 15, 2024 P275897
J2318372Certificate of AnalysisOct 07, 2023 P275897
J2318373Certificate of AnalysisOct 07, 2023 P275897
J2319377Certificate of AnalysisOct 07, 2023 P275897
J2319381Certificate of AnalysisOct 07, 2023 P275897

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Chemical and Physical Properties

SolubilityDMSO (Slightly), Ethanol (Slightly), Methanol (Slightly), Water (Slightly)
SensitivityAir & Light & Heat & Moisture sensitive

Related Documents

References

1. Latorre-Muro P et al..  (2021)  A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation..  Cell Metab,  33  (3): (598-614.e7).  [PMID:33592173]
2. He X et al..  (2022)  O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction..  Cell Death Differ,  29  (10): (1970-1981).  [PMID:35422493]

Solution Calculators