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Purmorphamine - 2mM in DMSO, high purity , CAS No.483367-10-8
Smoothened receptor agonist
Basic Description Synonyms CS-0626102 | 9-cyclohexyl-N-[4-(morpholin-4-yl)phenyl]-2-(naphthalen-1-yloxy)-9H-purin-6-amine | HSCI1_000224 | SMR004701397 | AKOS024458218 | SB19498 | Q15409344 | FT-0674154 | 9H-Purin-6-amine, 9-cyclohexyl-N-(4-(4-morpholinyl)phenyl)-2-(1-naphthalenylo Specifications & Purity Moligand™, 2mM in DMSO Biochemical and Physiological Mechanisms Purmorphamine, a purine derivative, has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. Additionally, this compound has been noted to display os Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™ Product Description Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine INCHI InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35) InChi Key FYBHCRQFSFYWPY-UHFFFAOYSA-N Canonical SMILES C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7 Isomeric SMILES C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7 WGK Germany 3 PubChem CID 5284329 Molecular Weight 520.62
Citations of This Product 1. Li Li, Qiuhong Li, Lei Wei, Zhongfu Wang, Wei Ma, Fangying Liu, Yanhua Shen, Shanfang Zhang, Xiulian Zhang, Huiping Li, Yechang Qian. (2019) Dexamethasone combined with berberine is an effective therapy for bleomycin‑induced pulmonary fibrosis in rats. Experimental and Therapeutic Medicine, 18 (4): (2385-2392). [PMID:31555349 ] [10.3892/etm.2019.7861 ]
References 1. Li Li, Qiuhong Li, Lei Wei, Zhongfu Wang, Wei Ma, Fangying Liu, Yanhua Shen, Shanfang Zhang, Xiulian Zhang, Huiping Li, Yechang Qian. (2019) Dexamethasone combined with berberine is an effective therapy for bleomycin‑induced pulmonary fibrosis in rats. Experimental and Therapeutic Medicine, 18 (4): (2385-2392). [PMID:31555349 ] [10.3892/etm.2019.7861 ]
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