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PXS-4681A , CAS No.P613021, Inhibitor of amine oxidase copper containing 3
Basic Description Specifications & Purity Moligand™ Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of amine oxidase copper containing 3
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 4-[(E)-2-(aminomethyl)-3-fluoroprop-2-enoxy]benzenesulfonamide INCHI InChI=1S/C10H13FN2O3S/c11-5-8(6-12)7-16-9-1-3-10(4-2-9)17(13,14)15/h1-5H,6-7,12H2,(H2,13,14,15)/b8-5+ InChi Key GJRSZKOPZAJCGZ-VMPITWQZSA-N Canonical SMILES NC/C(=C\F)/COc1ccc(cc1)S(=O)(=O)N Isomeric SMILES C1=CC(=CC=C1OC/C(=C/F)/CN)S(=O)(=O)N PubChem CID 72190183
References 1. Foot JS, Yow TT, Schilter H, Buson A, Deodhar M, Findlay AD, Guo L, McDonald IA, Turner CI, Zhou W et al. . (2013) PXS-4681A, a potent and selective mechanism-based inhibitor of SSAO/VAP-1 with anti-inflammatory effects in vivo.. J Pharmacol Exp Ther, 347 (2): (365-74). [PMID:23943052 ] 2. Becchi S, Buson A, Foot J, Jarolimek W, Balleine BW. (2017) Inhibition of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 reduces lipopolysaccharide-induced neuroinflammation.. Br J Pharmacol, 174 (14): (2302-2317). [PMID:28437839 ]
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