PXS-4728A , CAS No.P613022, Inhibitor of amine oxidase copper containing 3

Item Number

P613022

Grouped product items
SKU	Size	Availability	Price	Qty
P613022-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
P613022-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	MFI2XG2PVK \| PXS-4728 \| 1478364-40-7 \| Benzamide, 4-(((2E)-2-(aminomethyl)-3-fluoro-2-propen-1-yl)oxy)-N-(1,1-dimethylethyl)- \| 4-[(E)-2-(aminomethyl)-3-fluoroprop-2-enoxy]-N-tert-butylbenzamide \| (E)-4-((2-(Aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide \| U
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of amine oxidase copper containing 3

Associated Targets(Human)

AOC3 Tchem Membrane primary amine oxidase (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOB Tclin Monoamine oxidase B (8835 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AOC1 Tchem Diamine oxidase (68 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-[(E)-2-(aminomethyl)-3-fluoroprop-2-enoxy]-N-tert-butylbenzamide
INCHI	InChI=1S/C15H21FN2O2/c1-15(2,3)18-14(19)12-4-6-13(7-5-12)20-10-11(8-16)9-17/h4-8H,9-10,17H2,1-3H3,(H,18,19)/b11-8+
InChi Key	OWNSXNXYELKDSO-DHZHZOJOSA-N
Canonical SMILES	NC/C(=C\F)/COc1ccc(cc1)C(=O)NC(C)(C)C
Isomeric SMILES	CC(C)(C)NC(=O)C1=CC=C(C=C1)OC/C(=C/F)/CN
PubChem CID	71812247

References

1. Jarnicki AG, Schilter H, Liu G, Wheeldon K, Essilfie AT, Foot JS, Yow TT, Jarolimek W, Hansbro PM. (2016) The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model.. Br J Pharmacol, 173 (22): (3161-3175). [PMID:27495192] [10.1021/op500134e]
2. Schilter HC, Collison A, Russo RC, Foot JS, Yow TT, Vieira AT, Tavares LD, Mattes J, Teixeira MM, Jarolimek W. (2015) Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration.. Respir Res, 16 (13): (42). [PMID:25889951] [10.1021/op500134e]

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Basic Description