Pyridone 6 - ≥98%(HPLC), high purity , CAS No.457081-03-7, Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2

Item Number

P287366

Grouped product items
SKU	Size	Availability	Price
P287366-5mg	5mg	In stock	$117.90
P287366-10mg	10mg	In stock	$181.90
P287366-25mg	25mg	In stock	$408.90
P287366-50mg	50mg	In stock	$761.90
P287366-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,371.90

Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

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Basic Description

Synonyms	Pyridone 6\|457081-03-7\|JAK Inhibitor I\|Merck-5\|CMP 6\|Merck 5\|CMP-6\|pan-JAK inhibitor P6\|2-tert-butyl-9-fluoro-3H-benzo[h]imidazo[4,5-f]isoquinolin-7(6H)-one\|LDX3F0CCST\|2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one\|JA
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent pan-JAK inhibitor; ATP-competitive inhibitor of JAK 1/2/3 and Tyk2 (IC50values are 1, 5, 15 and 1 nM, respectively). Inhibits other kinases tested at 130 nM to >10 μM. Inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks STAT5 p
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2

Names and Identifiers

IUPAC Name	4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11.4.0.02,6.07,12]heptadeca-1(13),2(6),4,7(12),8,14,16-heptaen-11-one
INCHI	InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
InChi Key	VNDWQCSOSCCWIP-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O
Isomeric SMILES	CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O
PubChem CID	5494425
Molecular Weight	309.34

PubChem CID

DrugBank Ligand

ChEMBL Ligand

CAS Registry No.

RCSB PDB Ligand

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4 results found

Lot Number	Certificate Type	Date	Item
K2209769	Certificate of Analysis	Jul 21, 2022	P287366
K2209771	Certificate of Analysis	Jul 21, 2022	P287366
K2209859	Certificate of Analysis	Jul 21, 2022	P287366
K2210011	Certificate of Analysis	Jul 21, 2022	P287366

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Basic Description