Call +1 (833) 552-7181 or Contact us Earn $25 in coupons on your first order with Aladdin!
Toggle Nav
My Cart
Search
Advanced Search
Menu
Sign In
྾
main product photo

Pyridoxal 5′-phosphate hydrate - ≥98%, high purity , CAS No.853645-22-4

16 Citations
  • ≥98%
Item Number
P136795
Grouped product items
SKUSizeAvailabilityPrice Qty
P136795-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$43.90
P136795-5g
5g
In stock
$159.90
P136795-25g
25g
In stock
$546.90
P136795-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,966.90
Add to Wish List Compare
Bulk Order  SDS  DATASHEET

Basic Description

SynonymsVitazechs | FT-0631236 | P5P | P-5'-P | Pyromijin | 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate | CCG-266929 | EX-A980 | MC-1 | Pyridoxal 5/'-phosphate (hydrate) | SGCUT00188 | VITAMIN B6 (PYRIDOXAL 5-PHOSPHATE) | 3-hydroxy-2-methyl
Specifications & Purity≥98%
Biochemical and Physiological MechanismsPyridoxal 5′-phosphate is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. PLP is used in the studies of PLP-dependent e
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

 Product Description：

Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine.


 Product Application：

Pyridoxal 5′-phosphate hydrate has also been used: as a reference standard to quantify vitamin B6 in feed and digesta samples using high performance liquid chromatography (HPLC)； in D-amino acid transaminase reaction(10)；as a cofactor for L-glutamic acid decarboxylase

Associated Targets(Human)

P2RX1 Tchem P2X purinoceptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P2RX4 Tchem P2X purinoceptor 4 (516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P2RX1 Tchem P2X purinoceptor 1 (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAD Tchem Dihydroorotase (27 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPRB Tchem Receptor-type tyrosine-protein phosphatase beta (330 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1161 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

P2rx2 P2X purinoceptor 2 (106 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P2rx3 P2X purinoceptor 3 (632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trans-sialidase (51 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate
INCHI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChi Key NGVDGCNFYWLIFO-UHFFFAOYSA-N
Canonical SMILES CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
Isomeric SMILES CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
WGK Germany 3
PubChem CID 1051
Molecular Weight 247.14
Beilstein 234749

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
J2424255Certificate of AnalysisOct 31, 2024 P136795
K2125185Certificate of AnalysisSep 11, 2023 P136795
K2125309Certificate of AnalysisSep 11, 2023 P136795
F1509085Certificate of AnalysisJun 09, 2023 P136795
B2208069Certificate of AnalysisAug 27, 2021 P136795
D2321357Certificate of AnalysisAug 27, 2021 P136795
E2413020Certificate of AnalysisAug 27, 2021 P136795

Chemical and Physical Properties

Melt Point(°C)140-143°C

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

FAQs and Articles

FAQ
Synthesis and Metabolism of Glutamate and GABA: Core Mechanisms of Neurotransmitters
Categories: Technical articles
Tags:
Building Blocks Amino acids Vitamins GABA Metabolites Neurotransmitters Glutamate Glutamate/GABA metabolism Neural signaling pathways

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Hongpeng Wang, Mercy Vimbai Masuku, Yachen Tao, Jiayao Yang, Yi Kuang, Changjiang Lyu, Jun Huang, Shengxiang Yang.  (2023)  Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents.  MOLECULES,  28  (9): (3895).  [PMID:37175305] [10.3390/molecules28093895]
2. Xingchang Cha, Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su.  (2023)  High Production of γ-Aminobutyric Acid by Activating the xyl Operon of Lactobacillus brevis.  ACS Omega,  8  (8): (8101–8109).  [PMID:36873027] [10.1021/acsomega.2c08272]
3. Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin.  (2023)  A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity.  Catalysis Science & Technology,  13  (3): (684-693).  [PMID:] [10.1039/D2CY01670B]
4. Sai Fang, Haoran Yu, Lanxin Xiao, Zhe Wang, Yixuan Lei, Gang Xu, Lirong Yang, Wenlong Zheng, Jianping Wu.  (2022)  Counteracting the Activity-Diastereoselectivity Trade-Off of l-Threonine Aldolase by Regulating the Proton Transfer Microenvironment.  ADVANCED SYNTHESIS & CATALYSIS,  364  (24): (4363-4370).  [PMID:] [10.1002/adsc.202201006]
5. Guozeng Wang, Zhihao Jiang, Qing Xiao, Chang Jiang, Xian'ai Shi.  (2022)  Visible spectrophotometric assay for characterization of ω-transaminases.  ANALYTICAL BIOCHEMISTRY,  658  (114933).  [PMID:36208685] [10.1016/j.ab.2022.114933]
6. Li-Chao Wang, Lian Xu, Bing-Mei Su, Xin-Qi Xu, Juan Lin.  (2022)  An Effective Chemo-Enzymatic method with An Evolved L-Threonine Aldolase for Preparing L-threo-4-Methylsulfonylphenylserine Ethyl Ester of High Optical Purity.  Molecular Catalysis,  525  (112355).  [PMID:] [10.1016/j.mcat.2022.112355]
7. Lichao Wang, Lian Xu, Bingmei Su, Wei Lin, Xinqi Xu, Juan Lin.  (2021)  Improving the Cβ Stereoselectivity of l-Threonine Aldolase for the Synthesis of l-threo-4-Methylsulfonylphenylserine by Modulating the Substrate-Binding Pocket To Control the Orientation of the Substrate Entrance.  CHEMISTRY-A EUROPEAN JOURNAL,  27  (37): (9654-9660).  [PMID:33843095] [10.1002/chem.202100752]
8. Hongjie Hui, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai.  (2020)  Biosynthesis of Putrescine from L-arginine Using Engineered Escherichia coli Whole Cells.  Catalysts,  10  (9): (947).  [PMID:] [10.3390/catal10090947]
9. Li-Chao Wang, Lian Xu, Xin-Qi Xu, Bing-Mei Su, Juan Lin.  (2020)  An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids.  CHEMICAL ENGINEERING SCIENCE,  226  (115812).  [PMID:] [10.1016/j.ces.2020.115812]
10. Lian Xu, Li-Chao Wang, Xin-Qi Xu, Juan Lin.  (2019)  Characteristics of L-threonine transaldolase for asymmetric synthesis of β-hydroxy-α-amino acids.  Catalysis Science & Technology,  9  (21): (5943-5952).  [PMID:] [10.1039/C9CY01608B]
11. Xiao-Ling Tang, Nan-Nan Zhang, Guo-Yan Ye, Yu-Guo Zheng.  (2019)  Efficient biosynthesis of (R)-3-amino-1-butanol by a novel (R)-selective transaminase from Actinobacteria sp..  JOURNAL OF BIOTECHNOLOGY,  295  (49).  [PMID:30853639] [10.1016/j.jbiotec.2019.02.008]
12. Zhang Zhi-Jun, Cai Rui-Feng, Xu Jian-He.  (2018)  Characterization of a new nitrilase from Hoeflea phototrophica DFL-43 for a two-step one-pot synthesis of (S)-β-amino acids.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  102  (14): (6047-6056).  [PMID:29744634] [10.1007/s00253-018-9057-7]
13. Qian Wang, Xiao-Mei He, Xi Chen, Gang-Tian Zhu, Ren-Qi Wang, Yu-Qi Feng.  (2017)  Pyridoxal 5′-phosphate mediated preparation of immobilized metal affinity material for highly selective and sensitive enrichment of phosphopeptides.  JOURNAL OF CHROMATOGRAPHY A,  1499  (30).  [PMID:28390667] [10.1016/j.chroma.2017.03.085]
14. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li, Jingxin Li.  (2016)  l-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2S pathway in rodent jejunum.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,  43  (5): (562-568).  [PMID:26901099] [10.1111/1440-1681.12562]
15. S. Tang, D. Huang, N. An, D. Chen, D. Zhao.  (2016)  A novel pathway for the production of H2S by DAO in rat jejunum.  NEUROGASTROENTEROLOGY AND MOTILITY,  28  (5): (687-692).  [PMID:26813142] [10.1111/nmo.12765]
16. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li.  (2015-11-05)  H2S, a novel gasotransmitter, involves in gastric accommodation..  Scientific reports,  5  (16086-16086).  [PMID:26531221]

References

1. Masoud Vedadi,Frank H Niesen,Abdellah Allali-Hassani,Oleg Y Fedorov,Patrick J Finerty,Gregory A Wasney,Ron Yeung,Cheryl Arrowsmith,Linda J Ball,Helena Berglund,Raymond Hui,Brian D Marsden,Pär Nordlund,Michael Sundstrom,Johan Weigelt,Aled M Edwards.  (2006-10-13)  Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination..  Proceedings of the National Academy of Sciences of the United States of America,  103  ((43)): (15835-15840).  [PMID:17035505]
2. Kirsten R Wolthers,Stephen E J Rigby,Nigel S Scrutton.  (2008-10-25)  Mechanism of radical-based catalysis in the reaction catalyzed by adenosylcobalamin-dependent ornithine 4,5-aminomutase..  The Journal of biological chemistry,  283  ((50)): (34615-34625).  [PMID:18948256]
3. João Neres,Mark L Brewer,Laura Ratier,Horacio Botti,Alejandro Buschiazzo,Philip N Edwards,Paul N Mortenson,Michael H Charlton,Pedro M Alzari,Alberto C Frasch,Richard A Bryce,Kenneth T Douglas.  (2009-01-16)  Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening..  Bioorganic & medicinal chemistry letters,  19  ((3)): (589-596).  [PMID:19144516]
4. Eduardo F Oliveira, Nuno M F S A Cerqueira, Pedro A Fernandes, Maria J Ramos.  (2011-08-23)  Mechanism of formation of the internal aldimine in pyridoxal 5'-phosphate-dependent enzymes..  Journal of the American Chemical Society,  133  ((39)): (15496-15505).  [PMID:21854048]
5. Barbara Kappes,Ivo Tews,Alexandra Binter,Peter Macheroux.  (2011-09-03)  PLP-dependent enzymes as potential drug targets for protozoan diseases..  Biochimica et biophysica acta,  1814  ((11)): (1567-1576).  [PMID:21884827]
6. Caitlyn Makins,François N Miros,Nigel S Scrutton,Kirsten R Wolthers.  (2011-09-09)  Role of histidine 225 in adenosylcobalamin-dependent ornithine 4,5-aminomutase..  Bioorganic chemistry,  40  ((1)): (39-47).  [PMID:21899873]
7. Matthew C Clifton,Jan Abendroth,Thomas E Edwards,David J Leibly,Angela K Gillespie,Micah Ferrell,Shellie H Dieterich,Ilyssa Exley,Bart L Staker,Peter J Myler,Wesley C Van Voorhis,Lance J Stewart.  (2011-09-10)  Structure of the cystathionine γ-synthase MetB from Mycobacterium ulcerans..  Acta crystallographica. Section F, Structural biology and crystallization communications,  67  ((Pt 9)): (1154-1158).  [PMID:21904066]
8. Nema Hafezi,Jean-Marie Lehn.  (2012-07-13)  Adaptation of dynamic covalent systems of imine constituents to medium change by component redistribution under reversible phase separation..  Journal of the American Chemical Society,  134  ((30)): (12861-12868).  [PMID:22783895]
9. Ci-Di Chen,Hu Li,Jennifer Liang,Kathryn Hixson,Ella Zeldich,Carmela R Abraham.  (2014-06-09)  The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line..  Journal of molecular neuroscience : MN,  55  ((1)): (76-90).  [PMID:24907942]
10. Danielle Miller,Yu Wang,Huimin Xu,Kim Harich,Robert H White.  (2014-07-01)  Biosynthesis of the 5-(Aminomethyl)-3-furanmethanol moiety of methanofuran..  Biochemistry,  53  ((28)): (4635-4647).  [PMID:24977328]
11. Gelareh Vakilzadeh,Fariba Khodagholi,Tahereh Ghadiri,Marzieh Darvishi,Amir Ghaemi,Farshid Noorbakhsh,Ali Gorji,Mohammad Sharifzadeh.  (2014-08-17)  Protective Effect of a cAMP Analogue on Behavioral Deficits and Neuropathological Changes in Cuprizone Model of Demyelination..  Molecular neurobiology,  52  ((1)): (130-141).  [PMID:25128030]
12. Audrey Cheung,Peter Podgorny,Jose A Martinez,Cynthia Chan,Cory Toth.  (2014-08-19)  Epidermal axonal swellings in painful and painless diabetic peripheral neuropathy..  Muscle & nerve,  51  ((4)): (505-513).  [PMID:25130671]
13. Josephine M J Stoffels,Dick Hoekstra,Robin J M Franklin,Wia Baron,Chao Zhao.  (2014-08-27)  The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination..  Glia,  63  ((2)): (242-256).  [PMID:25156142]
14. Y Shi,J W Dong,L N Tang,R X Kang,J G Shi,J J Zhang.  (2014-09-17)  N(6)-(3-methoxyl-4-hydroxybenzyl) adenine riboside induces sedative and hypnotic effects via GAD enzyme activation in mice..  Pharmacology, biochemistry, and behavior,  126  (146-151).  [PMID:25223978]
15. Ashraf S A El-Sayed,Marwa A Yassin,Hend Ibrahim.  (2014-10-03)  Coimmobilization of l-methioninase and glutamate dehydrogenase: Novel approach for L-homoalanine synthesis..  Biotechnology and applied biochemistry,  62  ((4)): (514-522).  [PMID:25273833]
16. A Basic,G Dahlén.  (2014-10-05)  Hydrogen sulfide production from subgingival plaque samples..  Anaerobe,  35  ((Pt A)): (21-27).  [PMID:25280920]
17. Trina Das,Jean Jacques Hoarau,Marie Christine Jaffar Bandjee,Marianne Maquart,Philippe Gasque.  (2014-10-30)  Multifaceted innate immune responses engaged by astrocytes, microglia and resident dendritic cells against Chikungunya neuroinfection..  The Journal of general virology,  96  ((Pt 2)): (294-310).  [PMID:25351727]
18. Yi Zou,Wanxiang Jiang,Jianqing Wang,Zhongping Li,Junyan Zhang,Jicheng Bu,Jia Zou,Liang Zhou,Shouyang Yu,Yiyuan Cui,Weiwei Yang,Liping Luo,Qing R Lu,Yanhui Liu,Mina Chen,Paul F Worley,Bo Xiao.  (2014-11-21)  Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain..  The Journal of neuroscience : the official journal of the Society for Neuroscience,  34  ((47)): (15764-15778).  [PMID:25411504]
19. Akihiro Ishii,Miki Furusho,Jeffrey L Dupree,Rashmi Bansal.  (2014-11-28)  Role of ERK1/2 MAPK signaling in the maintenance of myelin and axonal integrity in the adult CNS..  The Journal of neuroscience : the official journal of the Society for Neuroscience,  34  ((48)): (16031-16045).  [PMID:25429144]
20. Sharadvi Thati,Christopher Kuehl,Brittany Hartwell,Joshua Sestak,Teruna Siahaan,M Laird Forrest,Cory Berkland.  (2014-12-03)  Routes of administration and dose optimization of soluble antigen arrays in mice with experimental autoimmune encephalomyelitis..  Journal of pharmaceutical sciences,  104  ((2)): (714-721).  [PMID:25447242]
21. James N Vranish,William K Russell,Lusa E Yu,Rachael M Cox,David H Russell,David P Barondeau.  (2014-12-06)  Fluorescent probes for tracking the transfer of iron-sulfur cluster and other metal cofactors in biosynthetic reaction pathways..  Journal of the American Chemical Society,  137  ((1)): (390-398).  [PMID:25478817]
22. Jorge Montesinos,María Pascual,Antoni Pla,Concepción Maldonado,Marta Rodríguez-Arias,Jose Miñarro,Consuelo Guerri.  (2014-12-09)  TLR4 elimination prevents synaptic and myelin alterations and long-term cognitive dysfunctions in adolescent mice with intermittent ethanol treatment..  Brain, behavior, and immunity,  45  (233-244).  [PMID:25486089]
23. Kira A Watkins,Rongjun Chen.  (2014-12-10)  pH-responsive, lysine-based hydrogels for the oral delivery of a wide size range of molecules..  International journal of pharmaceutics,  478  ((2)): (496-503).  [PMID:25490181]
24. Shashi Gandhi,Neha Gaur,Shagun Krishna,Mohd Imran Siddiqi,Jitendra Kumar Saxena.  (2014-12-17)  Arg-265: a critical residue of L.donovani cytosolic SHMT in maintaining the binding of THF and catalysis..  Experimental parasitology,  149  (16-23).  [PMID:25499510]
25. Bogdan F G Popescu,Yong Guo,Mark E Jentoft,Joseph E Parisi,Vanda A Lennon,Sean J Pittock,Brian G Weinshenker,Dean M Wingerchuk,Caterina Giannini,Imke Metz,Wolfgang Brück,Elizabeth A Shuster,Jonathan Carter,Clara D Boyd,Stacey Lynn Clardy,Bruce A Cohen,Claudia F Lucchinetti.  (2014-12-17)  Diagnostic utility of aquaporin-4 in the analysis of active demyelinating lesions..  Neurology,  84  ((2)): (148-158).  [PMID:25503621]
26. Marjolein Bijlard,Bert Klunder,Jenny C de Jonge,Anita Nomden,Sanjay Tyagi,Hans de Vries,Dick Hoekstra,Wia Baron.  (2014-12-17)  Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4: a potential correlation with autocrine signaling..  Molecular and cellular biology,  35  ((4)): (675-687).  [PMID:25512606]
27. Anthony G Dodge,Kelvin Carrasquillo,Luis Rivera,Lei Xu,Lawrence P Wackett,Michael J Sadowsky.  (2014-12-21)  Rapid method using two microbial enzymes for detection of L-abrine in food as a marker for the toxic protein abrin..  Applied and environmental microbiology,  81  ((5)): (1610-1615).  [PMID:25527549]
28. Laura K Mackay,Asolina Braun,Bethany L Macleod,Nicholas Collins,Christina Tebartz,Sammy Bedoui,Francis R Carbone,Thomas Gebhardt.  (2015-01-28)  Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention..  Journal of immunology (Baltimore, Md. : 1950),  194  ((5)): (2059-2063).  [PMID:25624457]
29. Hyesook Yoon,Maja Radulovic,Kristen L Drucker,Jianmin Wu,Isobel A Scarisbrick.  (2015-01-30)  The thrombin receptor is a critical extracellular switch controlling myelination..  Glia,  63  ((5)): (846-859).  [PMID:25628003]
30. Ao Zhang,Anne Desmazieres,Barbara Zonta,Shona Melrose,Graham Campbell,Don Mahad,Qiushi Li,Diane L Sherman,Richard Reynolds,Peter J Brophy.  (2015-02-06)  Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier..  The Journal of neuroscience : the official journal of the Society for Neuroscience,  35  ((5)): (2246-2254).  [PMID:25653379]
31. Dawid Deszcz,Pierre Affaticati,Nadine Ladkau,Alex Gegel,John M Ward,Helen C Hailes,Paul A Dalby.  (2015-04-08)  Single active-site mutants are sufficient to enhance serine:pyruvate α-transaminase activity in an ω-transaminase..  The FEBS journal,  282  ((13)): (2512-2526).  [PMID:25846556]
32. H K Palliser,M A Kelleher,M Tolcos,D W Walker,J J Hirst.  (2015-04-25)  Effect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs..  Journal of developmental origins of health and disease,  6  ((4)): (350-361).  [PMID:25907069]
33. Maren Lindner,Katja Thümmler,Ariel Arthur,Sarah Brunner,Christina Elliott,Daniel McElroy,Hema Mohan,Anna Williams,Julia M Edgar,Cornelia Schuh,Christine Stadelmann,Susan C Barnett,Hans Lassmann,Steve Mücklisch,Manikhandan Mudaliar,Nicole Schaeren-Wiemers,Edgar Meinl,Christopher Linington.  (2015-04-25)  Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9..  Brain : a journal of neurology,  138  ((Pt 7)): (1875-1893).  [PMID:25907862]
34. Fabrizio Angius,Maria Antonietta Madeddu,Raffaello Pompei.  (2015-05-06)  Nutritionally Variant Streptococci Interfere with Streptococcus mutans Adhesion Properties and Biofilm Formation..  The new microbiologica,  38  ((2)): (259-266).  [PMID:25938751]
35. Kelly Michel,Tianna Zhao,Molly Karl,Katherine Lewis,Sharyl L Fyffe-Maricich.  (2015-05-23)  Translational control of myelin basic protein expression by ERK2 MAP kinase regulates timely remyelination in the adult brain..  The Journal of neuroscience : the official journal of the Society for Neuroscience,  35  ((20)): (7850-7865).  [PMID:25995471]
36. Li-Jun Guan,Jun Ohtsuka,Masahiko Okai,Takuya Miyakawa,Tomoko Mase,Yuehua Zhi,Feng Hou,Noriyuki Ito,Akira Iwasaki,Yoshihiko Yasohara,Masaru Tanokura.  (2015-06-02)  A new target region for changing the substrate specificity of amine transaminases..  Scientific reports,  5  (10753-10753).  [PMID:26030619]
37. Xin-Wei Yang,Hua-Hua Jian,Feng-Ping Wang.  (2015-06-07)  pSW2, a Novel Low-Temperature-Inducible Gene Expression Vector Based on a Filamentous Phage of the Deep-Sea Bacterium Shewanella piezotolerans WP3..  Applied and environmental microbiology,  81  ((16)): (5519-5526).  [PMID:26048946]
38. Yanfei Zhang,Qinglong Meng,Hongwu Ma,Yongfei Liu,Guoqiang Cao,Xiaoran Zhang,Ping Zheng,Jibin Sun,Dawei Zhang,Wenxia Jiang,Yanhe Ma.  (2015-06-14)  Determination of key enzymes for threonine synthesis through in vitro metabolic pathway analysis..  Microbial cell factories,  14  (86-86).  [PMID:26070803]
39. Mi Ra Noh,Jee In Kim,Sang Jun Han,Tae-Jin Lee,Kwon Moo Park.  (2015-06-15)  C/EBP homologous protein (CHOP) gene deficiency attenuates renal ischemia/reperfusion injury in mice..  Biochimica et biophysica acta,  1852  ((9)): (1895-1901).  [PMID:26071644]
40. Sabine Pfeifenbring,Stefan Nessler,Christiane Wegner,Christine Stadelmann,Wolfgang Brück.  (2015-06-27)  Remyelination After Cuprizone-Induced Demyelination Is Accelerated in Juvenile Mice..  Journal of neuropathology and experimental neurology,  74  ((8)): (756-766).  [PMID:26115190]
41. Sang Jun Han,Jee In Kim,Jeen-Woo Park,Kwon Moo Park.  (2015-07-05)  Hydrogen sulfide accelerates the recovery of kidney tubules after renal ischemia/reperfusion injury..  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,  30  ((9)): (1497-1506).  [PMID:26142397]
42. Sagar V Chhabria,Mohammad A Akbarsha,Albert P Li,Prashant S Kharkar,Krutika B Desai.  (2015-08-20)  In situ allicin generation using targeted alliinase delivery for inhibition of MIA PaCa-2 cells via epigenetic changes, oxidative stress and cyclin-dependent kinase inhibitor (CDKI) expression..  Apoptosis : an international journal on programmed cell death,  20  ((10)): (1388-1409).  [PMID:26286853]
43. Eeva Castrén,Tarvo Sillat,Sofia Oja,Ariel Noro,Anita Laitinen,Yrjö T Konttinen,Petri Lehenkari,Mika Hukkanen,Matti Korhonen.  (2015-09-09)  Osteogenic differentiation of mesenchymal stromal cells in two-dimensional and three-dimensional cultures without animal serum..  Stem cell research & therapy,  6  (167-167).  [PMID:26345992]
44. Helena Maier,Lihua Wang-Eckhardt,Dieter Hartmann,Volkmar Gieselmann,Matthias Eckhardt.  (2015-10-30)  N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time..  The Journal of neuroscience : the official journal of the Society for Neuroscience,  35  ((43)): (14501-14516).  [PMID:26511242]
45. Karine Meisser Redeuil,Karin Longet,Sylvie Bénet,Caroline Munari,Esther Campos-Giménez.  (2015-11-03)  Simultaneous quantification of 21 water soluble vitamin circulating forms in human plasma by liquid chromatography-mass spectrometry..  Journal of chromatography. A,  1422  (89-98).  [PMID:26522745]
46. Massimo Barbierato,Laura Facci,Carla Marinelli,Morena Zusso,Carla Argentini,Stephen D Skaper,Pietro Giusti.  (2015-11-19)  Co-ultramicronized Palmitoylethanolamide/Luteolin Promotes the Maturation of Oligodendrocyte Precursor Cells..  Scientific reports,  5  (16676-16676).  [PMID:26578323]
47. Azita Hekmatdoost,Farhad Vahid,Zahra Yari,Mohammadreza Sadeghi,Hassan Eini-Zinab,Niknam Lakpour,Soheila Arefi.  (2015-12-03)  Methyltetrahydrofolate vs Folic Acid Supplementation in Idiopathic Recurrent Miscarriage with Respect to Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms: A Randomized Controlled Trial..  PloS one,  10  ((12)): (e0143569-e0143569).  [PMID:26630680]
48. Vayu Maini Rekdal,Elizabeth N Bess,Jordan E Bisanz,Peter J Turnbaugh,Emily P Balskus.  (2019-06-15)  Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism..  Science (New York, N.Y.),  364  ((6445)):   [PMID:31196984]
49. Qian Wang,Guochen Qin,Min Cao,Rong Chen,Yuming He,Liyuan Yang,Zhejun Zeng,Yongqiang Yu,Yangtao Gu,Weiman Xing,W Andy Tao,Tongda Xu.  (2020-02-06)  A phosphorylation-based switch controls TAA1-mediated auxin biosynthesis in plants..  Nature communications,  11  ((1)): (679-679).  [PMID:32015349]
50. Ling Li,Shuai Zhu,Wenjie Shu,Yueshuai Guo,Yusheng Guan,Juan Zeng,Haichao Wang,Longsen Han,Jiaqi Zhang,Xiaohui Liu,Chunling Li,Xiaojing Hou,Min Gao,Juan Ge,Chao Ren,Hao Zhang,Tim Schedl,Xuejiang Guo,Minjian Chen,Qiang Wang.  (2020-10-18)  Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation..  Molecular cell,  80  ((3)): (525-540).  [PMID:33068521]
51. Jun Araki,Hiromi Sakai,Dai Takeuchi,Yu Kagaya,Kensuke Tashiro,Munekazu Naito,Makoto Mihara,Mitsunaga Narushima,Takuya Iida,Isao Koshima.  (2015-01-22)  Normothermic preservation of the rat hind limb with artificial oxygen-carrying hemoglobin vesicles..  Transplantation,  99  ((4)): (687-692).  [PMID:25606798]
52. Yu Matsumoto,Yoshiaki Yasutake,Yuki Takeda,Tomohiro Tamura,Atsushi Yokota,Masaru Wada.  (2015-02-27)  Structural insights into the substrate stereospecificity of D-threo-3-hydroxyaspartate dehydratase from Delftia sp. HT23: a useful enzyme for the synthesis of optically pure L-threo- and D-erythro-3-hydroxyaspartate..  Applied microbiology and biotechnology,  99  ((17)): (7137-7150).  [PMID:25715785]
53. Dominik Sakry,Hatice Yigit,Leda Dimou,Jacqueline Trotter.  (2015-05-13)  Oligodendrocyte precursor cells synthesize neuromodulatory factors..  PloS one,  10  ((5)): (e0127222-e0127222).  [PMID:25966014]
54. Johan Puts,Monique de Groot,Martin Haex,Bernadette Jakobs.  (2015-07-03)  Simultaneous Determination of Underivatized Vitamin B1 and B6 in Whole Blood by Reversed Phase Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry..  PloS one,  10  ((7)): (e0132018-e0132018).  [PMID:26134844]
55. Brian R Lawson,Rosana Gonzalez-Quintial,Theodoros Eleftheriadis,Michael A Farrar,Stephen D Miller,Karsten Sauer,Dorian B McGavern,Dwight H Kono,Roberto Baccala,Argyrios N Theofilopoulos.  (2015-09-01)  Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation..  Clinical immunology (Orlando, Fla.),  161  ((2)): (260-269).  [PMID:26319414]
56. Barbora Waclawiková,Amber Bullock,Markus Schwalbe,Carmen Aranzamendi,Sieger A Nelemans,Gertjan van Dijk,Sahar El Aidy.  (2021-01-23)  Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels..  PLoS biology,  19  ((1)): (e3001070-e3001070).  [PMID:33481771]
57. Hongpeng Wang, Mercy Vimbai Masuku, Yachen Tao, Jiayao Yang, Yi Kuang, Changjiang Lyu, Jun Huang, Shengxiang Yang.  (2023)  Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents.  MOLECULES,  28  (9): (3895).  [PMID:37175305] [10.3390/molecules28093895]
58. Xingchang Cha, Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su.  (2023)  High Production of γ-Aminobutyric Acid by Activating the xyl Operon of Lactobacillus brevis.  ACS Omega,  8  (8): (8101–8109).  [PMID:36873027] [10.1021/acsomega.2c08272]
59. Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin.  (2023)  A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity.  Catalysis Science & Technology,  13  (3): (684-693).  [PMID:] [10.1039/D2CY01670B]
60. Sai Fang, Haoran Yu, Lanxin Xiao, Zhe Wang, Yixuan Lei, Gang Xu, Lirong Yang, Wenlong Zheng, Jianping Wu.  (2022)  Counteracting the Activity-Diastereoselectivity Trade-Off of l-Threonine Aldolase by Regulating the Proton Transfer Microenvironment.  ADVANCED SYNTHESIS & CATALYSIS,  364  (24): (4363-4370).  [PMID:] [10.1002/adsc.202201006]
61. Guozeng Wang, Zhihao Jiang, Qing Xiao, Chang Jiang, Xian'ai Shi.  (2022)  Visible spectrophotometric assay for characterization of ω-transaminases.  ANALYTICAL BIOCHEMISTRY,  658  (114933).  [PMID:36208685] [10.1016/j.ab.2022.114933]
62. Li-Chao Wang, Lian Xu, Bing-Mei Su, Xin-Qi Xu, Juan Lin.  (2022)  An Effective Chemo-Enzymatic method with An Evolved L-Threonine Aldolase for Preparing L-threo-4-Methylsulfonylphenylserine Ethyl Ester of High Optical Purity.  Molecular Catalysis,  525  (112355).  [PMID:] [10.1016/j.mcat.2022.112355]
63. Lichao Wang, Lian Xu, Bingmei Su, Wei Lin, Xinqi Xu, Juan Lin.  (2021)  Improving the Cβ Stereoselectivity of l-Threonine Aldolase for the Synthesis of l-threo-4-Methylsulfonylphenylserine by Modulating the Substrate-Binding Pocket To Control the Orientation of the Substrate Entrance.  CHEMISTRY-A EUROPEAN JOURNAL,  27  (37): (9654-9660).  [PMID:33843095] [10.1002/chem.202100752]
64. Hongjie Hui, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai.  (2020)  Biosynthesis of Putrescine from L-arginine Using Engineered Escherichia coli Whole Cells.  Catalysts,  10  (9): (947).  [PMID:] [10.3390/catal10090947]
65. Li-Chao Wang, Lian Xu, Xin-Qi Xu, Bing-Mei Su, Juan Lin.  (2020)  An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids.  CHEMICAL ENGINEERING SCIENCE,  226  (115812).  [PMID:] [10.1016/j.ces.2020.115812]
66. Lian Xu, Li-Chao Wang, Xin-Qi Xu, Juan Lin.  (2019)  Characteristics of L-threonine transaldolase for asymmetric synthesis of β-hydroxy-α-amino acids.  Catalysis Science & Technology,  9  (21): (5943-5952).  [PMID:] [10.1039/C9CY01608B]
67. Xiao-Ling Tang, Nan-Nan Zhang, Guo-Yan Ye, Yu-Guo Zheng.  (2019)  Efficient biosynthesis of (R)-3-amino-1-butanol by a novel (R)-selective transaminase from Actinobacteria sp..  JOURNAL OF BIOTECHNOLOGY,  295  (49).  [PMID:30853639] [10.1016/j.jbiotec.2019.02.008]
68. Zhang Zhi-Jun, Cai Rui-Feng, Xu Jian-He.  (2018)  Characterization of a new nitrilase from Hoeflea phototrophica DFL-43 for a two-step one-pot synthesis of (S)-β-amino acids.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  102  (14): (6047-6056).  [PMID:29744634] [10.1007/s00253-018-9057-7]
69. Qian Wang, Xiao-Mei He, Xi Chen, Gang-Tian Zhu, Ren-Qi Wang, Yu-Qi Feng.  (2017)  Pyridoxal 5′-phosphate mediated preparation of immobilized metal affinity material for highly selective and sensitive enrichment of phosphopeptides.  JOURNAL OF CHROMATOGRAPHY A,  1499  (30).  [PMID:28390667] [10.1016/j.chroma.2017.03.085]
70. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li, Jingxin Li.  (2016)  l-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2S pathway in rodent jejunum.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,  43  (5): (562-568).  [PMID:26901099] [10.1111/1440-1681.12562]
71. S. Tang, D. Huang, N. An, D. Chen, D. Zhao.  (2016)  A novel pathway for the production of H2S by DAO in rat jejunum.  NEUROGASTROENTEROLOGY AND MOTILITY,  28  (5): (687-692).  [PMID:26813142] [10.1111/nmo.12765]
72. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li.  (2015-11-05)  H2S, a novel gasotransmitter, involves in gastric accommodation..  Scientific reports,  5  (16086-16086).  [PMID:26531221]

Solution Calculators

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.