Pyridoxal 5′-phosphate hydrate - 10mM in DMSO, high purity , CAS No.853645-22-4

  • 10mM in DMSO
Item Number
P426327
Grouped product items
SKUSizeAvailabilityPrice Qty
P426327-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90

Basic Description

Synonymspyridoxal phosphate | 54-47-7 | Codecarboxylase | pyridoxal 5'-phosphate | pyridoxal 5-phosphate | Pyridoxyl phosphate | Pyridoxal P | Pyridoxal-5'-phosphate | Biosechs | Hairoxal | Pidopidon | Pyromijin | Vitazechs | (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phos
Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsPyridoxal 5′-phosphate is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. PLP is used in the studies of PLP-dependent e
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Product Description:

Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine.

Product Application:

Pyridoxal 5′-phosphate hydrate has also been used: as a reference standard to quantify vitamin B6 in feed and digesta samples using high performance liquid chromatography (HPLC); in D-amino acid transaminase reaction(10);as a cofactor for L-glutamic acid decarboxylase

Associated Targets(Human)

P2RX1 Tchem P2X purinoceptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P2RX4 Tchem P2X purinoceptor 4 (516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P2RX1 Tchem P2X purinoceptor 1 (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAD Tchem Dihydroorotase (27 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPRB Tchem Receptor-type tyrosine-protein phosphatase beta (330 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1161 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

P2rx2 P2X purinoceptor 2 (106 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P2rx3 P2X purinoceptor 3 (632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trans-sialidase (51 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate
INCHI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChi Key NGVDGCNFYWLIFO-UHFFFAOYSA-N
Canonical SMILES CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
Isomeric SMILES CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
WGK Germany 3
PubChem CID 1051
Molecular Weight 247.14
Beilstein 234749

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Melt Point(°C)140-143°C

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

Citations of This Product

1. Hongpeng Wang, Mercy Vimbai Masuku, Yachen Tao, Jiayao Yang, Yi Kuang, Changjiang Lyu, Jun Huang, Shengxiang Yang.  (2023)  Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents.  MOLECULES,  28  (9): (3895).  [PMID:37175305] [10.3390/molecules28093895]
2. Xingchang Cha, Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su.  (2023)  High Production of γ-Aminobutyric Acid by Activating the xyl Operon of Lactobacillus brevis.  ACS Omega,  (8): (8101–8109).  [PMID:36873027] [10.1021/acsomega.2c08272]
3. Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin.  (2023)  A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity.  Catalysis Science & Technology,  13  (3): (684-693).  [PMID:] [10.1039/D2CY01670B]
4. Sai Fang, Haoran Yu, Lanxin Xiao, Zhe Wang, Yixuan Lei, Gang Xu, Lirong Yang, Wenlong Zheng, Jianping Wu.  (2022)  Counteracting the Activity-Diastereoselectivity Trade-Off of l-Threonine Aldolase by Regulating the Proton Transfer Microenvironment.  ADVANCED SYNTHESIS & CATALYSIS,  364  (24): (4363-4370).  [PMID:] [10.1002/adsc.202201006]
5. Guozeng Wang, Zhihao Jiang, Qing Xiao, Chang Jiang, Xian'ai Shi.  (2022)  Visible spectrophotometric assay for characterization of ω-transaminases.  ANALYTICAL BIOCHEMISTRY,  658  (114933).  [PMID:36208685] [10.1016/j.ab.2022.114933]
6. Lichao Wang, Lian Xu, Bingmei Su, Wei Lin, Xinqi Xu, Juan Lin.  (2021)  Improving the Cβ Stereoselectivity of l-Threonine Aldolase for the Synthesis of l-threo-4-Methylsulfonylphenylserine by Modulating the Substrate-Binding Pocket To Control the Orientation of the Substrate Entrance.  CHEMISTRY-A EUROPEAN JOURNAL,  27  (37): (9654-9660).  [PMID:33843095] [10.1002/chem.202100752]
7. Hongjie Hui, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai.  (2020)  Biosynthesis of Putrescine from L-arginine Using Engineered Escherichia coli Whole Cells.  Catalysts,  10  (9): (947).  [PMID:] [10.3390/catal10090947]
8. Li-Chao Wang, Lian Xu, Xin-Qi Xu, Bing-Mei Su, Juan Lin.  (2020)  An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids.  CHEMICAL ENGINEERING SCIENCE,  226  (115812).  [PMID:] [10.1016/j.ces.2020.115812]
9. Lian Xu, Li-Chao Wang, Xin-Qi Xu, Juan Lin.  (2019)  Characteristics of L-threonine transaldolase for asymmetric synthesis of β-hydroxy-α-amino acids.  Catalysis Science & Technology,  (21): (5943-5952).  [PMID:] [10.1039/C9CY01608B]
10. Xiao-Ling Tang, Nan-Nan Zhang, Guo-Yan Ye, Yu-Guo Zheng.  (2019)  Efficient biosynthesis of (R)-3-amino-1-butanol by a novel (R)-selective transaminase from Actinobacteria sp..  JOURNAL OF BIOTECHNOLOGY,  295  (49).  [PMID:30853639] [10.1016/j.jbiotec.2019.02.008]
11. Zhang Zhi-Jun, Cai Rui-Feng, Xu Jian-He.  (2018)  Characterization of a new nitrilase from Hoeflea phototrophica DFL-43 for a two-step one-pot synthesis of (S)-β-amino acids.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  102  (14): (6047-6056).  [PMID:29744634] [10.1007/s00253-018-9057-7]
12. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li, Jingxin Li.  (2016)  l-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2S pathway in rodent jejunum.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,  43  (5): (562-568).  [PMID:26901099] [10.1111/1440-1681.12562]
13. S. Tang, D. Huang, N. An, D. Chen, D. Zhao.  (2016)  A novel pathway for the production of H2S by DAO in rat jejunum.  NEUROGASTROENTEROLOGY AND MOTILITY,  28  (5): (687-692).  [PMID:26813142] [10.1111/nmo.12765]
14. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li.  (2015-11-05)  H2S, a novel gasotransmitter, involves in gastric accommodation..  Scientific reports,  (16086-16086).  [PMID:26531221]

References

1. Hongpeng Wang, Mercy Vimbai Masuku, Yachen Tao, Jiayao Yang, Yi Kuang, Changjiang Lyu, Jun Huang, Shengxiang Yang.  (2023)  Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents.  MOLECULES,  28  (9): (3895).  [PMID:37175305] [10.3390/molecules28093895]
2. Xingchang Cha, Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su.  (2023)  High Production of γ-Aminobutyric Acid by Activating the xyl Operon of Lactobacillus brevis.  ACS Omega,  (8): (8101–8109).  [PMID:36873027] [10.1021/acsomega.2c08272]
3. Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin.  (2023)  A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity.  Catalysis Science & Technology,  13  (3): (684-693).  [PMID:] [10.1039/D2CY01670B]
4. Sai Fang, Haoran Yu, Lanxin Xiao, Zhe Wang, Yixuan Lei, Gang Xu, Lirong Yang, Wenlong Zheng, Jianping Wu.  (2022)  Counteracting the Activity-Diastereoselectivity Trade-Off of l-Threonine Aldolase by Regulating the Proton Transfer Microenvironment.  ADVANCED SYNTHESIS & CATALYSIS,  364  (24): (4363-4370).  [PMID:] [10.1002/adsc.202201006]
5. Guozeng Wang, Zhihao Jiang, Qing Xiao, Chang Jiang, Xian'ai Shi.  (2022)  Visible spectrophotometric assay for characterization of ω-transaminases.  ANALYTICAL BIOCHEMISTRY,  658  (114933).  [PMID:36208685] [10.1016/j.ab.2022.114933]
6. Lichao Wang, Lian Xu, Bingmei Su, Wei Lin, Xinqi Xu, Juan Lin.  (2021)  Improving the Cβ Stereoselectivity of l-Threonine Aldolase for the Synthesis of l-threo-4-Methylsulfonylphenylserine by Modulating the Substrate-Binding Pocket To Control the Orientation of the Substrate Entrance.  CHEMISTRY-A EUROPEAN JOURNAL,  27  (37): (9654-9660).  [PMID:33843095] [10.1002/chem.202100752]
7. Hongjie Hui, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai.  (2020)  Biosynthesis of Putrescine from L-arginine Using Engineered Escherichia coli Whole Cells.  Catalysts,  10  (9): (947).  [PMID:] [10.3390/catal10090947]
8. Li-Chao Wang, Lian Xu, Xin-Qi Xu, Bing-Mei Su, Juan Lin.  (2020)  An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids.  CHEMICAL ENGINEERING SCIENCE,  226  (115812).  [PMID:] [10.1016/j.ces.2020.115812]
9. Lian Xu, Li-Chao Wang, Xin-Qi Xu, Juan Lin.  (2019)  Characteristics of L-threonine transaldolase for asymmetric synthesis of β-hydroxy-α-amino acids.  Catalysis Science & Technology,  (21): (5943-5952).  [PMID:] [10.1039/C9CY01608B]
10. Xiao-Ling Tang, Nan-Nan Zhang, Guo-Yan Ye, Yu-Guo Zheng.  (2019)  Efficient biosynthesis of (R)-3-amino-1-butanol by a novel (R)-selective transaminase from Actinobacteria sp..  JOURNAL OF BIOTECHNOLOGY,  295  (49).  [PMID:30853639] [10.1016/j.jbiotec.2019.02.008]
11. Zhang Zhi-Jun, Cai Rui-Feng, Xu Jian-He.  (2018)  Characterization of a new nitrilase from Hoeflea phototrophica DFL-43 for a two-step one-pot synthesis of (S)-β-amino acids.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  102  (14): (6047-6056).  [PMID:29744634] [10.1007/s00253-018-9057-7]
12. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li, Jingxin Li.  (2016)  l-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2S pathway in rodent jejunum.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,  43  (5): (562-568).  [PMID:26901099] [10.1111/1440-1681.12562]
13. S. Tang, D. Huang, N. An, D. Chen, D. Zhao.  (2016)  A novel pathway for the production of H2S by DAO in rat jejunum.  NEUROGASTROENTEROLOGY AND MOTILITY,  28  (5): (687-692).  [PMID:26813142] [10.1111/nmo.12765]
14. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li.  (2015-11-05)  H2S, a novel gasotransmitter, involves in gastric accommodation..  Scientific reports,  (16086-16086).  [PMID:26531221]

Solution Calculators