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SKU | Size | Availability | Price | Qty |
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P426327-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 |
Synonyms | pyridoxal phosphate | 54-47-7 | Codecarboxylase | pyridoxal 5'-phosphate | pyridoxal 5-phosphate | Pyridoxyl phosphate | Pyridoxal P | Pyridoxal-5'-phosphate | Biosechs | Hairoxal | Pidopidon | Pyromijin | Vitazechs | (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phos |
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Specifications & Purity | 10mM in DMSO |
Biochemical and Physiological Mechanisms | Pyridoxal 5′-phosphate is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. PLP is used in the studies of PLP-dependent e |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | Product Description: Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine. Product Application: Pyridoxal 5′-phosphate hydrate has also been used: as a reference standard to quantify vitamin B6 in feed and digesta samples using high performance liquid chromatography (HPLC); in D-amino acid transaminase reaction(10);as a cofactor for L-glutamic acid decarboxylase |
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IUPAC Name | (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate |
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INCHI | InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) |
InChi Key | NGVDGCNFYWLIFO-UHFFFAOYSA-N |
Canonical SMILES | CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O |
Isomeric SMILES | CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O |
WGK Germany | 3 |
PubChem CID | 1051 |
Molecular Weight | 247.14 |
Beilstein | 234749 |
Enter Lot Number to search for COA:
Melt Point(°C) | 140-143°C |
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WGK Germany | 3 |
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1. Hongpeng Wang, Mercy Vimbai Masuku, Yachen Tao, Jiayao Yang, Yi Kuang, Changjiang Lyu, Jun Huang, Shengxiang Yang. (2023) Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents. MOLECULES, 28 (9): (3895). [PMID:37175305] [10.3390/molecules28093895] |
2. Xingchang Cha, Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su. (2023) High Production of γ-Aminobutyric Acid by Activating the xyl Operon of Lactobacillus brevis. ACS Omega, 8 (8): (8101–8109). [PMID:36873027] [10.1021/acsomega.2c08272] |
3. Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin. (2023) A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity. Catalysis Science & Technology, 13 (3): (684-693). [PMID:] [10.1039/D2CY01670B] |
4. Sai Fang, Haoran Yu, Lanxin Xiao, Zhe Wang, Yixuan Lei, Gang Xu, Lirong Yang, Wenlong Zheng, Jianping Wu. (2022) Counteracting the Activity-Diastereoselectivity Trade-Off of l-Threonine Aldolase by Regulating the Proton Transfer Microenvironment. ADVANCED SYNTHESIS & CATALYSIS, 364 (24): (4363-4370). [PMID:] [10.1002/adsc.202201006] |
5. Guozeng Wang, Zhihao Jiang, Qing Xiao, Chang Jiang, Xian'ai Shi. (2022) Visible spectrophotometric assay for characterization of ω-transaminases. ANALYTICAL BIOCHEMISTRY, 658 (114933). [PMID:36208685] [10.1016/j.ab.2022.114933] |
6. Lichao Wang, Lian Xu, Bingmei Su, Wei Lin, Xinqi Xu, Juan Lin. (2021) Improving the Cβ Stereoselectivity of l-Threonine Aldolase for the Synthesis of l-threo-4-Methylsulfonylphenylserine by Modulating the Substrate-Binding Pocket To Control the Orientation of the Substrate Entrance. CHEMISTRY-A EUROPEAN JOURNAL, 27 (37): (9654-9660). [PMID:33843095] [10.1002/chem.202100752] |
7. Hongjie Hui, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai. (2020) Biosynthesis of Putrescine from L-arginine Using Engineered Escherichia coli Whole Cells. Catalysts, 10 (9): (947). [PMID:] [10.3390/catal10090947] |
8. Li-Chao Wang, Lian Xu, Xin-Qi Xu, Bing-Mei Su, Juan Lin. (2020) An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids. CHEMICAL ENGINEERING SCIENCE, 226 (115812). [PMID:] [10.1016/j.ces.2020.115812] |
9. Lian Xu, Li-Chao Wang, Xin-Qi Xu, Juan Lin. (2019) Characteristics of L-threonine transaldolase for asymmetric synthesis of β-hydroxy-α-amino acids. Catalysis Science & Technology, 9 (21): (5943-5952). [PMID:] [10.1039/C9CY01608B] |
10. Xiao-Ling Tang, Nan-Nan Zhang, Guo-Yan Ye, Yu-Guo Zheng. (2019) Efficient biosynthesis of (R)-3-amino-1-butanol by a novel (R)-selective transaminase from Actinobacteria sp.. JOURNAL OF BIOTECHNOLOGY, 295 (49). [PMID:30853639] [10.1016/j.jbiotec.2019.02.008] |
11. Zhang Zhi-Jun, Cai Rui-Feng, Xu Jian-He. (2018) Characterization of a new nitrilase from Hoeflea phototrophica DFL-43 for a two-step one-pot synthesis of (S)-β-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 102 (14): (6047-6056). [PMID:29744634] [10.1007/s00253-018-9057-7] |
12. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li, Jingxin Li. (2016) l-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2S pathway in rodent jejunum. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 43 (5): (562-568). [PMID:26901099] [10.1111/1440-1681.12562] |
13. S. Tang, D. Huang, N. An, D. Chen, D. Zhao. (2016) A novel pathway for the production of H2S by DAO in rat jejunum. NEUROGASTROENTEROLOGY AND MOTILITY, 28 (5): (687-692). [PMID:26813142] [10.1111/nmo.12765] |
14. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li. (2015-11-05) H2S, a novel gasotransmitter, involves in gastric accommodation.. Scientific reports, 5 (16086-16086). [PMID:26531221] |
1. Hongpeng Wang, Mercy Vimbai Masuku, Yachen Tao, Jiayao Yang, Yi Kuang, Changjiang Lyu, Jun Huang, Shengxiang Yang. (2023) Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents. MOLECULES, 28 (9): (3895). [PMID:37175305] [10.3390/molecules28093895] |
2. Xingchang Cha, Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su. (2023) High Production of γ-Aminobutyric Acid by Activating the xyl Operon of Lactobacillus brevis. ACS Omega, 8 (8): (8101–8109). [PMID:36873027] [10.1021/acsomega.2c08272] |
3. Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin. (2023) A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity. Catalysis Science & Technology, 13 (3): (684-693). [PMID:] [10.1039/D2CY01670B] |
4. Sai Fang, Haoran Yu, Lanxin Xiao, Zhe Wang, Yixuan Lei, Gang Xu, Lirong Yang, Wenlong Zheng, Jianping Wu. (2022) Counteracting the Activity-Diastereoselectivity Trade-Off of l-Threonine Aldolase by Regulating the Proton Transfer Microenvironment. ADVANCED SYNTHESIS & CATALYSIS, 364 (24): (4363-4370). [PMID:] [10.1002/adsc.202201006] |
5. Guozeng Wang, Zhihao Jiang, Qing Xiao, Chang Jiang, Xian'ai Shi. (2022) Visible spectrophotometric assay for characterization of ω-transaminases. ANALYTICAL BIOCHEMISTRY, 658 (114933). [PMID:36208685] [10.1016/j.ab.2022.114933] |
6. Lichao Wang, Lian Xu, Bingmei Su, Wei Lin, Xinqi Xu, Juan Lin. (2021) Improving the Cβ Stereoselectivity of l-Threonine Aldolase for the Synthesis of l-threo-4-Methylsulfonylphenylserine by Modulating the Substrate-Binding Pocket To Control the Orientation of the Substrate Entrance. CHEMISTRY-A EUROPEAN JOURNAL, 27 (37): (9654-9660). [PMID:33843095] [10.1002/chem.202100752] |
7. Hongjie Hui, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai. (2020) Biosynthesis of Putrescine from L-arginine Using Engineered Escherichia coli Whole Cells. Catalysts, 10 (9): (947). [PMID:] [10.3390/catal10090947] |
8. Li-Chao Wang, Lian Xu, Xin-Qi Xu, Bing-Mei Su, Juan Lin. (2020) An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids. CHEMICAL ENGINEERING SCIENCE, 226 (115812). [PMID:] [10.1016/j.ces.2020.115812] |
9. Lian Xu, Li-Chao Wang, Xin-Qi Xu, Juan Lin. (2019) Characteristics of L-threonine transaldolase for asymmetric synthesis of β-hydroxy-α-amino acids. Catalysis Science & Technology, 9 (21): (5943-5952). [PMID:] [10.1039/C9CY01608B] |
10. Xiao-Ling Tang, Nan-Nan Zhang, Guo-Yan Ye, Yu-Guo Zheng. (2019) Efficient biosynthesis of (R)-3-amino-1-butanol by a novel (R)-selective transaminase from Actinobacteria sp.. JOURNAL OF BIOTECHNOLOGY, 295 (49). [PMID:30853639] [10.1016/j.jbiotec.2019.02.008] |
11. Zhang Zhi-Jun, Cai Rui-Feng, Xu Jian-He. (2018) Characterization of a new nitrilase from Hoeflea phototrophica DFL-43 for a two-step one-pot synthesis of (S)-β-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 102 (14): (6047-6056). [PMID:29744634] [10.1007/s00253-018-9057-7] |
12. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li, Jingxin Li. (2016) l-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2S pathway in rodent jejunum. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 43 (5): (562-568). [PMID:26901099] [10.1111/1440-1681.12562] |
13. S. Tang, D. Huang, N. An, D. Chen, D. Zhao. (2016) A novel pathway for the production of H2S by DAO in rat jejunum. NEUROGASTROENTEROLOGY AND MOTILITY, 28 (5): (687-692). [PMID:26813142] [10.1111/nmo.12765] |
14. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li. (2015-11-05) H2S, a novel gasotransmitter, involves in gastric accommodation.. Scientific reports, 5 (16086-16086). [PMID:26531221] |