Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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P101874-1g | 1g | In stock | $82.90 | |
P101874-5g | 5g | In stock | $373.90 | |
P101874-10g | 10g | In stock | $672.90 | |
P101874-25g | 25g | In stock | $1,512.90 | |
P101874-100g | 100g | In stock | $5,445.90 | |
P101874-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $24,505.90 |
Synonyms | pyridoxal phosphate | 54-47-7 | Codecarboxylase | pyridoxal 5'-phosphate | pyridoxal 5-phosphate | Pyridoxyl phosphate | Pyridoxal P | Pyridoxal-5'-phosphate | Biosechs | Hairoxal | Pidopidon | Pyromijin | Vitazechs | (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phos |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Pyridoxal 5′-phosphate (PLP) aids in carbohydrate and fat metabolism by serving as a cofactor. It is majorly responsible for catalyzing the enzymatic reactions involved in sphingolipid synthesis and neurotransmitter (dopamine and serotonin) synthesis. PLP |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine.
Pyridoxal 5′-phosphate hydrate has also been used:
• as a reference standard to quantify vitamin B6 in feed and digesta samples using high performance liquid chromatography (HPLC)
• in D-amino acid transaminase reaction(10)
• as a cofactor for L-glutamic acid decarboxylase |
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IUPAC Name | (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate |
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INCHI | InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) |
InChi Key | NGVDGCNFYWLIFO-UHFFFAOYSA-N |
Canonical SMILES | CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O |
Isomeric SMILES | CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O |
PubChem CID | 1051 |
Molecular Weight | 247.14 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
E2209055 | Certificate of Analysis | Feb 23, 2024 | P101874 |
E2209052 | Certificate of Analysis | Feb 23, 2024 | P101874 |
E2209054 | Certificate of Analysis | Feb 23, 2024 | P101874 |
I2126311 | Certificate of Analysis | Jul 10, 2023 | P101874 |
I2126310 | Certificate of Analysis | Jul 10, 2023 | P101874 |
B2327513 | Certificate of Analysis | Mar 01, 2023 | P101874 |
B2327667 | Certificate of Analysis | Mar 01, 2023 | P101874 |
B2327530 | Certificate of Analysis | Mar 01, 2023 | P101874 |
F2428046 | Certificate of Analysis | Jan 12, 2023 | P101874 |
G2305718 | Certificate of Analysis | Jan 12, 2023 | P101874 |
G2305812 | Certificate of Analysis | Jan 12, 2023 | P101874 |
G2305813 | Certificate of Analysis | Jan 12, 2023 | P101874 |
G2305814 | Certificate of Analysis | Jan 12, 2023 | P101874 |
G2305815 | Certificate of Analysis | Jan 12, 2023 | P101874 |
G2305816 | Certificate of Analysis | Jan 12, 2023 | P101874 |
G2305817 | Certificate of Analysis | Jan 12, 2023 | P101874 |
G2305818 | Certificate of Analysis | Jan 12, 2023 | P101874 |
G2305819 | Certificate of Analysis | Jan 12, 2023 | P101874 |
G2305820 | Certificate of Analysis | Jan 12, 2023 | P101874 |
G2305821 | Certificate of Analysis | Jan 12, 2023 | P101874 |
G2305822 | Certificate of Analysis | Jan 12, 2023 | P101874 |
A2303251 | Certificate of Analysis | Nov 23, 2022 | P101874 |
Solubility | Soluble in oxygen-free H2O. Insoluble in most organic solvents. |
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Sensitivity | Moisture sensitive |
Melt Point(°C) | 140-143°C |
Starting at $62.90
Starting at $69.90
Starting at $69.90
Starting at $69.90
Starting at $43.90
Starting at $17.90
1. Zixin Teng, Xuewei Pan, Yunran Liu, Jiajia You, Hengwei Zhang, Zhenqiang Zhao, Zhina Qiao, Zhiming Rao. (2024) Engineering serine hydroxymethyltransferases for efficient synthesis of L-serine in Escherichia coli. BIORESOURCE TECHNOLOGY, 393 (22): (130153). [PMID:38052329] |
2. Nan Jiang, Xiaotong Du, Liangyu Zheng. (2023) Highly efficient synthesis of chiral lactams by using a ω-transaminase from Bacillus megaterium and its mutant enzymes. Molecular Catalysis, 547 (113364). [PMID:] |
3. Hongpeng Wang, Mercy Vimbai Masuku, Yachen Tao, Jiayao Yang, Yi Kuang, Changjiang Lyu, Jun Huang, Shengxiang Yang. (2023) Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents. MOLECULES, 28 (9): (3895). [PMID:37175305] |
4. Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su. (2023) Development of an oil-sealed anaerobic fermentation process for high production of γ-aminobutyric acid with Lactobacillus brevis isolated by directional colorimetric screening. BIOCHEMICAL ENGINEERING JOURNAL, 194 (108893). [PMID:] |
5. Xiao-Ling Tang, Ning Li, Yan-Lai Liu, Jing-Peng Li, Kai-Xuan Zhao, Zhi-Qiang Liu, Yu-Guo Zheng. (2023) Engineering O-Succinyl-L-Homoserine Mercaptotransferase for Efficient L-Methionine Biosynthesis by Fermentation-Enzymatic Coupling Route. ADVANCED SYNTHESIS & CATALYSIS, 365 (7): (1048-1057). [PMID:] |
6. Xingchang Cha, Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su. (2023) High Production of γ-Aminobutyric Acid by Activating the xyl Operon of Lactobacillus brevis. ACS Omega, 8 (8): (8101–8109). [PMID:36873027] |
7. Shiyi Wang, Yiwen Zhao, Shufen Mao, Jiang Zhu, Yangyang Zhan, Dongbo Cai, Xin Ma, Dong Wang, Shouwen Chen. (2023) Enhancing the activity of disulfide-bond-containing proteins via promoting disulfide bond formation in Bacillus licheniformis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 233 (123468). [PMID:36731702] |
8. Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin. (2023) A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity. Catalysis Science & Technology, 13 (3): (684-693). [PMID:] |
9. Sai Fang, Haoran Yu, Lanxin Xiao, Zhe Wang, Yixuan Lei, Gang Xu, Lirong Yang, Wenlong Zheng, Jianping Wu. (2022) Counteracting the Activity-Diastereoselectivity Trade-Off of l-Threonine Aldolase by Regulating the Proton Transfer Microenvironment. ADVANCED SYNTHESIS & CATALYSIS, 364 (24): (4363-4370). [PMID:] |
10. Kai Yuan, Kai Huang, Yiqi Yang, Yixuan Lin, Yihao Liu, Fupeng Li, Yakun Liang, Haishuang Chang, Yuhui Chen, Tingting Tang, Shengbing Yang. (2022) Multi-roles of nanoscale bismuth metal-organic frameworks: Infectious photoacoustic probe and inhibitor of antibiotics tolerant bacteria via targeting endogenous H2S. Nano Today, 47 (101683). [PMID:] |
11. Guozeng Wang, Zhihao Jiang, Qing Xiao, Chang Jiang, Xian'ai Shi. (2022) Visible spectrophotometric assay for characterization of ω-transaminases. ANALYTICAL BIOCHEMISTRY, 658 (114933). [PMID:36208685] |
12. Deng Hao-Hua, Yang Hui-Jing, Huang Kai-Yuan, Zheng Yi-Jing, Xu Ying-Ying, Peng Hua-Ping, Liu Yin-Huan, Chen Wei, Hong Guo-Lin. (2022) Antenna effect of pyridoxal phosphate on the fluorescence of mitoxantrone-silicon nanoparticles and its application in alkaline phosphatase assay. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (17): (4877-4884). [PMID:35576012] |
13. Li-Chao Wang, Lian Xu, Bing-Mei Su, Xin-Qi Xu, Juan Lin. (2022) An Effective Chemo-Enzymatic method with An Evolved L-Threonine Aldolase for Preparing L-threo-4-Methylsulfonylphenylserine Ethyl Ester of High Optical Purity. Molecular Catalysis, 525 (112355). [PMID:] |
14. Wang Dong-En, You Shangqi, Huo Wenjing, Han Xiang, Xu Huiyun. (2022) Colorimetric detection of alkaline phosphatase activity based on pyridoxal phosphate–induced chromatic switch of polydiacetylene nano-liposomes. MICROCHIMICA ACTA, 189 (2): (1-12). [PMID:35067757] |
15. Hang-Qin Zhu, Wen-Ye Hu, Xiao-Ling Tang, Ren-Chao Zheng, Yu-Guo Zheng. (2022) High-throughput assay of tyrosine phenol-lyase activity using a cascade of enzymatic reactions. ANALYTICAL BIOCHEMISTRY, 640 (114547). [PMID:35026146] |
16. Jiahao Yao, Zhuang Li, Xiuling Ji, Yaju Xue, Baozeng Ren, Hai Zhao, Yuhong Huang. (2021) Novel enzyme-metal-organic framework composite for efficient cadaverine production. BIOCHEMICAL ENGINEERING JOURNAL, 176 (108222). [PMID:] |
17. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li. (2015-11-05) H2S, a novel gasotransmitter, involves in gastric accommodation.. Scientific reports, 5 (16086-16086). [PMID:26531221] |
1. Zixin Teng, Xuewei Pan, Yunran Liu, Jiajia You, Hengwei Zhang, Zhenqiang Zhao, Zhina Qiao, Zhiming Rao. (2024) Engineering serine hydroxymethyltransferases for efficient synthesis of L-serine in Escherichia coli. BIORESOURCE TECHNOLOGY, 393 (22): (130153). [PMID:38052329] |
2. Nan Jiang, Xiaotong Du, Liangyu Zheng. (2023) Highly efficient synthesis of chiral lactams by using a ω-transaminase from Bacillus megaterium and its mutant enzymes. Molecular Catalysis, 547 (113364). [PMID:] |
3. Hongpeng Wang, Mercy Vimbai Masuku, Yachen Tao, Jiayao Yang, Yi Kuang, Changjiang Lyu, Jun Huang, Shengxiang Yang. (2023) Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents. MOLECULES, 28 (9): (3895). [PMID:37175305] |
4. Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su. (2023) Development of an oil-sealed anaerobic fermentation process for high production of γ-aminobutyric acid with Lactobacillus brevis isolated by directional colorimetric screening. BIOCHEMICAL ENGINEERING JOURNAL, 194 (108893). [PMID:] |
5. Xiao-Ling Tang, Ning Li, Yan-Lai Liu, Jing-Peng Li, Kai-Xuan Zhao, Zhi-Qiang Liu, Yu-Guo Zheng. (2023) Engineering O-Succinyl-L-Homoserine Mercaptotransferase for Efficient L-Methionine Biosynthesis by Fermentation-Enzymatic Coupling Route. ADVANCED SYNTHESIS & CATALYSIS, 365 (7): (1048-1057). [PMID:] |
6. Xingchang Cha, Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su. (2023) High Production of γ-Aminobutyric Acid by Activating the xyl Operon of Lactobacillus brevis. ACS Omega, 8 (8): (8101–8109). [PMID:36873027] |
7. Shiyi Wang, Yiwen Zhao, Shufen Mao, Jiang Zhu, Yangyang Zhan, Dongbo Cai, Xin Ma, Dong Wang, Shouwen Chen. (2023) Enhancing the activity of disulfide-bond-containing proteins via promoting disulfide bond formation in Bacillus licheniformis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 233 (123468). [PMID:36731702] |
8. Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin. (2023) A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity. Catalysis Science & Technology, 13 (3): (684-693). [PMID:] |
9. Sai Fang, Haoran Yu, Lanxin Xiao, Zhe Wang, Yixuan Lei, Gang Xu, Lirong Yang, Wenlong Zheng, Jianping Wu. (2022) Counteracting the Activity-Diastereoselectivity Trade-Off of l-Threonine Aldolase by Regulating the Proton Transfer Microenvironment. ADVANCED SYNTHESIS & CATALYSIS, 364 (24): (4363-4370). [PMID:] |
10. Kai Yuan, Kai Huang, Yiqi Yang, Yixuan Lin, Yihao Liu, Fupeng Li, Yakun Liang, Haishuang Chang, Yuhui Chen, Tingting Tang, Shengbing Yang. (2022) Multi-roles of nanoscale bismuth metal-organic frameworks: Infectious photoacoustic probe and inhibitor of antibiotics tolerant bacteria via targeting endogenous H2S. Nano Today, 47 (101683). [PMID:] |
11. Guozeng Wang, Zhihao Jiang, Qing Xiao, Chang Jiang, Xian'ai Shi. (2022) Visible spectrophotometric assay for characterization of ω-transaminases. ANALYTICAL BIOCHEMISTRY, 658 (114933). [PMID:36208685] |
12. Deng Hao-Hua, Yang Hui-Jing, Huang Kai-Yuan, Zheng Yi-Jing, Xu Ying-Ying, Peng Hua-Ping, Liu Yin-Huan, Chen Wei, Hong Guo-Lin. (2022) Antenna effect of pyridoxal phosphate on the fluorescence of mitoxantrone-silicon nanoparticles and its application in alkaline phosphatase assay. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (17): (4877-4884). [PMID:35576012] |
13. Li-Chao Wang, Lian Xu, Bing-Mei Su, Xin-Qi Xu, Juan Lin. (2022) An Effective Chemo-Enzymatic method with An Evolved L-Threonine Aldolase for Preparing L-threo-4-Methylsulfonylphenylserine Ethyl Ester of High Optical Purity. Molecular Catalysis, 525 (112355). [PMID:] |
14. Wang Dong-En, You Shangqi, Huo Wenjing, Han Xiang, Xu Huiyun. (2022) Colorimetric detection of alkaline phosphatase activity based on pyridoxal phosphate–induced chromatic switch of polydiacetylene nano-liposomes. MICROCHIMICA ACTA, 189 (2): (1-12). [PMID:35067757] |
15. Hang-Qin Zhu, Wen-Ye Hu, Xiao-Ling Tang, Ren-Chao Zheng, Yu-Guo Zheng. (2022) High-throughput assay of tyrosine phenol-lyase activity using a cascade of enzymatic reactions. ANALYTICAL BIOCHEMISTRY, 640 (114547). [PMID:35026146] |
16. Jiahao Yao, Zhuang Li, Xiuling Ji, Yaju Xue, Baozeng Ren, Hai Zhao, Yuhong Huang. (2021) Novel enzyme-metal-organic framework composite for efficient cadaverine production. BIOCHEMICAL ENGINEERING JOURNAL, 176 (108222). [PMID:] |
17. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li. (2015-11-05) H2S, a novel gasotransmitter, involves in gastric accommodation.. Scientific reports, 5 (16086-16086). [PMID:26531221] |