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Pyridoxal phosphate - 98%，for cell culture, high purity , CAS No.54-47-7

35 Citations
Item Number
P101875
Grouped product items
SKUSizeAvailabilityPrice Qty
P101875-1g
1g
In stock
$62.90
P101875-5g
5g
In stock
$283.90
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Basic Description

SynonymsVitazechs | FT-0631236 | P5P | P-5'-P | Pyromijin | 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate | CCG-266929 | EX-A980 | MC-1 | Pyridoxal 5/'-phosphate (hydrate) | SGCUT00188 | VITAMIN B6 (PYRIDOXAL 5-PHOSPHATE) | 3-hydroxy-2-methyl
Specifications & PurityMoligand™, for cell culture, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Gradefor cell culture, Moligand™

Associated Targets(Human)

P2RX1 Tchem P2X purinoceptor 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P2RX4 Tchem P2X purinoceptor 4 (516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P2RX1 Tchem P2X purinoceptor 1 (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAD Tchem Dihydroorotase (27 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPRB Tchem Receptor-type tyrosine-protein phosphatase beta (330 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1161 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

P2rx2 P2X purinoceptor 2 (106 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P2rx3 P2X purinoceptor 3 (632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trans-sialidase (51 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate
INCHI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChi Key NGVDGCNFYWLIFO-UHFFFAOYSA-N
Canonical SMILES CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
Isomeric SMILES CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
PubChem CID 1051
Molecular Weight 247.14

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
B2327575Certificate of AnalysisJan 12, 2023 P101875
B2327890Certificate of AnalysisJan 12, 2023 P101875

Chemical and Physical Properties

Melt Point(°C)140-143°C

Related Documents

 SDS

 Specification Sheet

FAQs and Articles

FAQ
Synthesis and Metabolism of Glutamate and GABA: Core Mechanisms of Neurotransmitters
Categories: Technical articles
Tags:
Building Blocks Amino acids Vitamins GABA Metabolites Neurotransmitters Glutamate Glutamate/GABA metabolism Neural signaling pathways

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Zixin Teng, Xuewei Pan, Yunran Liu, Jiajia You, Hengwei Zhang, Zhenqiang Zhao, Zhina Qiao, Zhiming Rao.  (2024)  Engineering serine hydroxymethyltransferases for efficient synthesis of L-serine in Escherichia coli.  BIORESOURCE TECHNOLOGY,  393  (22): (130153).  [PMID:38052329] [10.1016/j.biortech.2023.130153]
2. Nan Jiang, Xiaotong Du, Liangyu Zheng.  (2023)  Highly efficient synthesis of chiral lactams by using a ω-transaminase from Bacillus megaterium and its mutant enzymes.  Molecular Catalysis,  547  (113364).  [PMID:] [10.1016/j.mcat.2023.113364]
3. Hongpeng Wang, Mercy Vimbai Masuku, Yachen Tao, Jiayao Yang, Yi Kuang, Changjiang Lyu, Jun Huang, Shengxiang Yang.  (2023)  Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents.  MOLECULES,  28  (9): (3895).  [PMID:37175305] [10.3390/molecules28093895]
4. Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su.  (2023)  Development of an oil-sealed anaerobic fermentation process for high production of γ-aminobutyric acid with Lactobacillus brevis isolated by directional colorimetric screening.  BIOCHEMICAL ENGINEERING JOURNAL,  194  (108893).  [PMID:] [10.1016/j.bej.2023.108893]
5. Xiao-Ling Tang, Ning Li, Yan-Lai Liu, Jing-Peng Li, Kai-Xuan Zhao, Zhi-Qiang Liu, Yu-Guo Zheng.  (2023)  Engineering O-Succinyl-L-Homoserine Mercaptotransferase for Efficient L-Methionine Biosynthesis by Fermentation-Enzymatic Coupling Route.  ADVANCED SYNTHESIS & CATALYSIS,  365  (7): (1048-1057).  [PMID:] [10.1002/adsc.202300030]
6. Xingchang Cha, Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su.  (2023)  High Production of γ-Aminobutyric Acid by Activating the xyl Operon of Lactobacillus brevis.  ACS Omega,  8  (8): (8101–8109).  [PMID:36873027] [10.1021/acsomega.2c08272]
7. Shiyi Wang, Yiwen Zhao, Shufen Mao, Jiang Zhu, Yangyang Zhan, Dongbo Cai, Xin Ma, Dong Wang, Shouwen Chen.  (2023)  Enhancing the activity of disulfide-bond-containing proteins via promoting disulfide bond formation in Bacillus licheniformis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  233  (123468).  [PMID:36731702] [10.1016/j.ijbiomac.2023.123468]
8. Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin.  (2023)  A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity.  Catalysis Science & Technology,  13  (3): (684-693).  [PMID:] [10.1039/D2CY01670B]
9. Sai Fang, Haoran Yu, Lanxin Xiao, Zhe Wang, Yixuan Lei, Gang Xu, Lirong Yang, Wenlong Zheng, Jianping Wu.  (2022)  Counteracting the Activity-Diastereoselectivity Trade-Off of l-Threonine Aldolase by Regulating the Proton Transfer Microenvironment.  ADVANCED SYNTHESIS & CATALYSIS,  364  (24): (4363-4370).  [PMID:] [10.1002/adsc.202201006]
10. Kai Yuan, Kai Huang, Yiqi Yang, Yixuan Lin, Yihao Liu, Fupeng Li, Yakun Liang, Haishuang Chang, Yuhui Chen, Tingting Tang, Shengbing Yang.  (2022)  Multi-roles of nanoscale bismuth metal-organic frameworks: Infectious photoacoustic probe and inhibitor of antibiotics tolerant bacteria via targeting endogenous H2S.  Nano Today,  47  (101683).  [PMID:] [10.1016/j.nantod.2022.101683]
11. Guozeng Wang, Zhihao Jiang, Qing Xiao, Chang Jiang, Xian'ai Shi.  (2022)  Visible spectrophotometric assay for characterization of ω-transaminases.  ANALYTICAL BIOCHEMISTRY,  658  (114933).  [PMID:36208685] [10.1016/j.ab.2022.114933]
12. Deng Hao-Hua, Yang Hui-Jing, Huang Kai-Yuan, Zheng Yi-Jing, Xu Ying-Ying, Peng Hua-Ping, Liu Yin-Huan, Chen Wei, Hong Guo-Lin.  (2022)  Antenna effect of pyridoxal phosphate on the fluorescence of mitoxantrone-silicon nanoparticles and its application in alkaline phosphatase assay.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  414  (17): (4877-4884).  [PMID:35576012] [10.1007/s00216-022-04110-7]
13. Li-Chao Wang, Lian Xu, Bing-Mei Su, Xin-Qi Xu, Juan Lin.  (2022)  An Effective Chemo-Enzymatic method with An Evolved L-Threonine Aldolase for Preparing L-threo-4-Methylsulfonylphenylserine Ethyl Ester of High Optical Purity.  Molecular Catalysis,  525  (112355).  [PMID:] [10.1016/j.mcat.2022.112355]
14. Wang Dong-En, You Shangqi, Huo Wenjing, Han Xiang, Xu Huiyun.  (2022)  Colorimetric detection of alkaline phosphatase activity based on pyridoxal phosphate–induced chromatic switch of polydiacetylene nano-liposomes.  MICROCHIMICA ACTA,  189  (2): (1-12).  [PMID:35067757] [10.1007/s00604-022-05175-y]
15. Hang-Qin Zhu, Wen-Ye Hu, Xiao-Ling Tang, Ren-Chao Zheng, Yu-Guo Zheng.  (2022)  High-throughput assay of tyrosine phenol-lyase activity using a cascade of enzymatic reactions.  ANALYTICAL BIOCHEMISTRY,  640  (114547).  [PMID:35026146] [10.1016/j.ab.2022.114547]
16. Jiahao Yao, Zhuang Li, Xiuling Ji, Yaju Xue, Baozeng Ren, Hai Zhao, Yuhong Huang.  (2021)  Novel enzyme-metal-organic framework composite for efficient cadaverine production.  BIOCHEMICAL ENGINEERING JOURNAL,  176  (108222).  [PMID:] [10.1016/j.bej.2021.108222]
17. Hu Jiawei, Li Wei, Liu Zhan, Zhang Guolin, Luo Yinggang.  (2021)  Molecular cloning and functional characterization of tyrosine decarboxylases from galanthamine-producing Lycoris radiata.  ACTA PHYSIOLOGIAE PLANTARUM,  43  (6): (1-12).  [PMID:] [10.1007/s11738-021-03258-6]
18. Zhu Wen-Yuan, Niu Kun, Liu Peng, Fan Yu-Hang, Liu Zhi-Qiang, Zheng Yu-Guo.  (2021)  Identification and Characterization of an O-Succinyl-L-Homoserine Sulfhydrylase From Thioalkalivibrio sulfidiphilus.  Frontiers in Chemistry,  9    [PMID:33937207] [10.3389/fchem.2021.672414]
19. Lichao Wang, Lian Xu, Bingmei Su, Wei Lin, Xinqi Xu, Juan Lin.  (2021)  Improving the Cβ Stereoselectivity of l-Threonine Aldolase for the Synthesis of l-threo-4-Methylsulfonylphenylserine by Modulating the Substrate-Binding Pocket To Control the Orientation of the Substrate Entrance.  CHEMISTRY-A EUROPEAN JOURNAL,  27  (37): (9654-9660).  [PMID:33843095] [10.1002/chem.202100752]
20. Jingbai Wen, Jie Bao.  (2021)  Improved fermentative γ-aminobutyric acid production by secretory expression of glutamate decarboxylase by Corynebacterium glutamicum.  JOURNAL OF BIOTECHNOLOGY,  331  (19).  [PMID:33711360] [10.1016/j.jbiotec.2021.03.003]
21. Hongjie Hui, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai.  (2020)  Biosynthesis of Putrescine from L-arginine Using Engineered Escherichia coli Whole Cells.  Catalysts,  10  (9): (947).  [PMID:] [10.3390/catal10090947]
22. Li-Chao Wang, Lian Xu, Xin-Qi Xu, Bing-Mei Su, Juan Lin.  (2020)  An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids.  CHEMICAL ENGINEERING SCIENCE,  226  (115812).  [PMID:] [10.1016/j.ces.2020.115812]
23. Zhu Hang-Qin, Tang Xiao-Ling, Zheng Ren-Chao, Zheng Yu-Guo.  (2020)  Purification and Biochemical Characterization of a Tyrosine Phenol-lyase from Morganella morganii.  APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,  192  (1): (71-84).  [PMID:32236865] [10.1007/s12010-020-03301-1]
24. Hao-Hua Deng, Kai-Yuan Huang, Quan-Hui Fang, Ya-Ping Lv, Shao-Bin He, Hua-Ping Peng, Xing-Hua Xia, Wei Chen.  (2020)  Schiff base and Lewis acid-base interaction-regulated aggregation/dispersion of gold nanoparticles for colorimetric recognition of rare-earth Sc3+ ions.  SENSORS AND ACTUATORS B-CHEMICAL,  311  (127925).  [PMID:] [10.1016/j.snb.2020.127925]
25. Hao-Hua Deng, Kai-Yuan Huang, Shao-Bin He, Li-Ping Xue, Hua-Ping Peng, Dai-Jun Zha, Wei-Ming Sun, Xing-Hua Xia, Wei Chen.  (2020)  Rational Design of High-Performance Donor–Linker–Acceptor Hybrids Using a Schiff Base for Enabling Photoinduced Electron Transfer.  ANALYTICAL CHEMISTRY,  92  (2): (2019–2026).  [PMID:31854983] [10.1021/acs.analchem.9b04434]
26. Lian Xu, Li-Chao Wang, Xin-Qi Xu, Juan Lin.  (2019)  Characteristics of L-threonine transaldolase for asymmetric synthesis of β-hydroxy-α-amino acids.  Catalysis Science & Technology,  9  (21): (5943-5952).  [PMID:] [10.1039/C9CY01608B]
27. Xiao-Ling Tang, Nan-Nan Zhang, Guo-Yan Ye, Yu-Guo Zheng.  (2019)  Efficient biosynthesis of (R)-3-amino-1-butanol by a novel (R)-selective transaminase from Actinobacteria sp..  JOURNAL OF BIOTECHNOLOGY,  295  (49).  [PMID:30853639] [10.1016/j.jbiotec.2019.02.008]
28. Xiao-Ling Tang, Hui Suo, Ren-Chao Zheng, Yu-Guo Zheng.  (2018)  An efficient colorimetric high-throughput screening method for synthetic activity of tyrosine phenol-lyase.  ANALYTICAL BIOCHEMISTRY,  560  (7).  [PMID:30176231] [10.1016/j.ab.2018.08.026]
29. Zhang Zhi-Jun, Cai Rui-Feng, Xu Jian-He.  (2018)  Characterization of a new nitrilase from Hoeflea phototrophica DFL-43 for a two-step one-pot synthesis of (S)-β-amino acids.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  102  (14): (6047-6056).  [PMID:29744634] [10.1007/s00253-018-9057-7]
30. Qian Wang, Xiao-Mei He, Xi Chen, Gang-Tian Zhu, Ren-Qi Wang, Yu-Qi Feng.  (2017)  Pyridoxal 5′-phosphate mediated preparation of immobilized metal affinity material for highly selective and sensitive enrichment of phosphopeptides.  JOURNAL OF CHROMATOGRAPHY A,  1499  (30).  [PMID:28390667] [10.1016/j.chroma.2017.03.085]
31. Wu Hua-Lei, Zhang Jian-Dong, Zhang Chao-Feng, Fan Xiao-Jun, Chang Hong-Hong, Wei Wen-Long.  (2017)  Characterization of Four New Distinct ω-Transaminases from Pseudomonas putida NBRC 14164 for Kinetic Resolution of Racemic Amines and Amino Alcohols.  APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,  181  (3): (972-985).  [PMID:27714638] [10.1007/s12010-016-2263-9]
32. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li, Jingxin Li.  (2016)  l-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2S pathway in rodent jejunum.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,  43  (5): (562-568).  [PMID:26901099] [10.1111/1440-1681.12562]
33. S. Tang, D. Huang, N. An, D. Chen, D. Zhao.  (2016)  A novel pathway for the production of H2S by DAO in rat jejunum.  NEUROGASTROENTEROLOGY AND MOTILITY,  28  (5): (687-692).  [PMID:26813142] [10.1111/nmo.12765]
34. Miao Chen, Liya Rong, Xiaoqing Chen.  (2015)  A simple and sensitive detection of glutamic-pyruvic transaminase activity based on fluorescence quenching of bovine serum albumin.  RSC Advances,  5  (125): (103557-103562).  [PMID:] [10.1039/C5RA24162F]
35. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li.  (2015-11-05)  H2S, a novel gasotransmitter, involves in gastric accommodation..  Scientific reports,  5  (16086-16086).  [PMID:26531221]

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