QNZ (EVP4593) - ≥98%, high purity , CAS No.545380-34-5

Item Number

Q125550

• Synonyms: 545380-34-5 | QNZ | 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline | EVP4593 | QNZ (EVP4593) | N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine | 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine | EVP-4593 | NF-kB activation inhibitor | QNZ(EVP4593) | N4-[2-(4-phenoxyph
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling. Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection. Research results suggest that QN
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively.
An inhibitor of the transcription factor NFκB.