QS11 - ≥98%, high purity , CAS No.944328-88-5

Item Number

Q274976

Grouped product items
SKU	Size	Availability	Price
Q274976-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$105.90
Q274976-10mg	10mg	In stock	$189.90
Q274976-25mg	25mg	In stock	$426.90
Q274976-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$759.90
Q274976-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,305.90

ARFGAP1 inhibitor. Wnt/β-catenin pathway modulator.

Basic Description

Synonyms	QS11\|944328-88-5\|QS 11\|QS11 free\|CHEMBL259181\|(S)-2-((9-([1,1'-biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino)-3-phenylpropan-1-ol\|(2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino]-3-phenyl
Specifications & Purity	≥98%
Storage Temp	Protected from light,Store at -20°C
Shipped In	Dry ice
Product Description	Product description QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 µM. QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells.

Names and Identifiers

IUPAC Name	(2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino]-3-phenylpropan-1-ol
INCHI	InChI=1S/C36H33N5O2/c42-23-31(20-25-8-3-1-4-9-25)38-34-33-35(40-36(39-34)43-32-19-18-28-12-7-13-30(28)21-32)41(24-37-33)22-26-14-16-29(17-15-26)27-10-5-2-6-11-27/h1-6,8-11,14-19,21,24,31,42H,7,12-13,20,22-23H2,(H,38,39,40)/t31-/m0/s1
InChi Key	DOKZLKDGUQWMSX-HKBQPEDESA-N
Canonical SMILES	C1CC2=C(C1)C=C(C=C2)OC3=NC(=C4C(=N3)N(C=N4)CC5=CC=C(C=C5)C6=CC=CC=C6)NC(CC7=CC=CC=C7)CO
Isomeric SMILES	C1CC2=C(C1)C=C(C=C2)OC3=NC(=C4C(=N3)N(C=N4)CC5=CC=C(C=C5)C6=CC=CC=C6)N[C@@H](CC7=CC=CC=C7)CO
PubChem CID	42623900
Molecular Weight	567.68

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
C23021044	Certificate of Analysis	Dec 20, 2023	Q274976
C23021189	Certificate of Analysis	Dec 20, 2023	Q274976
C23021197	Certificate of Analysis	Dec 20, 2023	Q274976
C23021201	Certificate of Analysis	Dec 20, 2023	Q274976
C23021278	Certificate of Analysis	Dec 20, 2023	Q274976

Solubility

Soluble in DMSO to 100 mM and in ethanol to 100 mM

Sensitivity

light sensitive

Solution Calculators

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Basic Description