The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Quazinone (Ro 13-6438) , CAS No.70018-51-8
a phosphodiesterase inhibitor and novel cardiotonic agent with vasodilating properties
Basic Description Synonyms Quazinona | Ro 13-6438; Ro 13-6438/006 | (3R)-6-chloro-3-methyl-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one | QUAZINONE [USAN] | Q7269633 | QUAZINONE [INN] | (3R)-6-chloro-3-methyl-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one | DT-0021 | Tox21_111263 Storage Temp Room temperature Shipped In Normal Product Description Quazinone (Ro 13-6438) is a selective phosphodiesterase (PDE) inhibitor, and a novel cardiotonic agent with vasodilating properties. It has been reported to inhibit myocardial PDE activity and elevate levels of intracellular cyclic AMP (cAMP), causing a positive inotropic response in isolated guina pig papillary muscle. It has been shown to increase the upstroke velocity, overshoot, and duration of slow action potentials in a concentration-dependent fashion in partially depolarized papillary muscles.
Product Properties pKa pKa: 12.38 (Predicted), pKa: 0.84 (Predicted)
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (3R)-6-chloro-3-methyl-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one INCHI InChI=1S/C11H10ClN3O/c1-6-10(16)14-11-13-9-4-2-3-8(12)7(9)5-15(6)11/h2-4,6H,5H2,1H3,(H,13,14,16)/t6-/m1/s1 InChi Key BHZFZYLBVSWUMT-ZCFIWIBFSA-N Canonical SMILES CC1C(=O)NC2=NC3=C(CN12)C(=CC=C3)Cl Isomeric SMILES C[C@@H]1C(=O)NC2=NC3=C(CN12)C(=CC=C3)Cl WGK Germany 3 PubChem CID 135418296 Molecular Weight 235.67
Chemical and Physical Properties Solubility Soluble in DMSO (3 mg/ml), ethanol (1 mg/ml), and water (5 mg/ml). Refractive Index n20D1.75 (Predicted) Boil Point(°C) 345.57° C at 760 mmHg (Predicted) Melt Point(°C) 189.32° C (Predicted)
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
