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Quercetagetin - 98%, high purity , CAS No.90-18-6
an ATP-competitive flavanol inhibitor of Pim-1 (PIM1) kinase
Basic Description Synonyms 2-(3,4-Dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4-benzopyrone | Quercetagenin | SV68G507VO | 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy- | 3,3'4,5,6,7-hexOH-Flavone | MYU | A843465 | CHEBI:8695 | DTXCID30160469 | ZVOLCUVKHLEPEV-UHFFF Specifications & Purity ≥98% Storage Temp Protected from light,Store at -20°C Shipped In Ice chest + Ice pads Product Description Quercetagetin is a cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC50 = 340 nM). Exhibits ≥7-fold selectivity over 8 other kinases tested, including PIM2 (IC50 = 3.45 μM), and little activity toward c-Abl even at concentrations as high as 200 μM. Inhibits cellular BAD phosphorylation (IC50 = 5.5 μM) and induces growth arrest (ED50 = 3.8 μM) in PIM1-expressing RWPE2 cells.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers Pubchem Sid 488195242 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488195242 IUPAC Name 2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxychromen-4-one INCHI InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H InChi Key ZVOLCUVKHLEPEV-UHFFFAOYSA-N Canonical SMILES C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C(=C3O)O)O)O)O)O Isomeric SMILES C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C(=C3O)O)O)O)O)O PubChem CID 5281680 Molecular Weight 318.23
Chemical and Physical Properties Solubility Soluble in DMSO. Sensitivity Light sensitive Refractive Index n20D1.86 (Predicted) Boil Point(°C) ~732.4° C at 760 mmHg (Predicted) Melt Point(°C) 252.31° C (Predicted)
Citations of This Product 1. Yue Zhuo, Yuehui Liang, Duoxia Xu, David Julian McClements, Suqing Wang, Qi Li, Yahong Han, Fuguo Liu, Shuai Chen. (2023) Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 242 (125109). [PMID:37257529 ] [10.1016/j.ijbiomac.2023.125109 ]
References 1. Yue Zhuo, Yuehui Liang, Duoxia Xu, David Julian McClements, Suqing Wang, Qi Li, Yahong Han, Fuguo Liu, Shuai Chen. (2023) Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 242 (125109). [PMID:37257529 ] [10.1016/j.ijbiomac.2023.125109 ]
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