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Quilizumab (anti-IgE) - Primary antibody, specific to IGHE, Human IgG1, Antibody of immunoglobulin heavy constant epsilon

≥95%(SDS-PAGE&SEC)
Lot by Lot

Features and benefits

Short Overview:
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Species reactivity(Reacts with): Human
Isotype: Human IgG1

Application:

Animal Model
ELISA
Flow Cytometry
Functional Assay

Item Number

Ab175636

Grouped product items
SKU	Size	Availability	Price
Ab175636-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$89.90
Ab175636-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$419.90
Ab175636-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,089.90
Ab175636-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,749.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series

Click to view target information: IGHE

Accession#:P01854 Gene ID:3497 IgE IGHE

Basic Description

Product Name	Quilizumab (anti-IgE) - Primary antibody, specific to IGHE, Human IgG1
Synonyms	Igh2 antibodyIGHE antibody \| IGHEP1 antibody \| Immunoglobulin heavy constant epsilon antibody \| IgE \| immunoglobulin heavy constant epsilon \| Anti-Human NGcGM3 Recombinant Antibody
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Specificity	IGHE
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	Antibody of immunoglobulin heavy constant epsilon
Product Description	Quilizumab (anti-IgE) is a humanized IgG1κ monoclonal antibody. Quilizumab (anti-IgE) targets the M1-prime segment of membrane-expressed IgE, leading to depletion of IgE-switched and memory B cells. Quilizumab (anti-IgE) has the potantial for the asthma research. Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg

Product Properties

Isotype	Human IgG1
Light Chain Type	kappa
SDS-PAGE	146.5 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	1228538-47-3

Associated Targets(Human)

IGHE Tclin Immunoglobulin heavy constant epsilon (0 Activities)

Discover Target: IGHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IGHE Tclin Ig epsilon chain C region (0 Activities)

Discover Target: IGHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

References

1. Gauvreau GM, Harris JM, Boulet LP, Scheerens H, Fitzgerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y et al.. (2014) Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production.. Sci Transl Med, 6 (243): (243ra85). [PMID:24990880]
2. Pennington LF, Gasser P, Brigger D, Guntern P, Eggel A, Jardetzky TS. (2021) Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions.. J Allergy Clin Immunol, 129 (3): (589-97). [PMID:33991582]
3. Kolkhir P, Altrichter S, Munoz M, Hawro T, Maurer M. (2020) New treatments for chronic urticaria.. Ann Allergy Asthma Immunol, 124 (1): (2-12). [PMID:31446134]

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Quilizumab (anti-IgE) - Primary antibody, specific to IGHE, Human IgG1, Antibody of immunoglobulin heavy constant epsilon

Basic Description

Product Properties

Associated Targets(Human)

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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