Quilizumab (anti-IgE) - Primary antibody, specific to IGHE, Human IgG1, Antibody of immunoglobulin heavy constant epsilon

Application:

Features and benefits

Item Number

Ab175636

Grouped product items
SKU	Size	Availability	Price
Ab175636-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$89.90
Ab175636-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$419.90
Ab175636-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,089.90
Ab175636-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,749.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series

Basic Description

Product Name	Quilizumab (anti-IgE) - Primary antibody, specific to IGHE, Human IgG1
Synonyms	Igh2 antibodyIGHE antibody \| IGHEP1 antibody \| Immunoglobulin heavy constant epsilon antibody \| IgE \| immunoglobulin heavy constant epsilon \| Anti-Human NGcGM3 Recombinant Antibody
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Host species	Human
Specificity	IGHE
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	Antibody of immunoglobulin heavy constant epsilon
Product Description	Quilizumab (anti-IgE) is a humanized IgG1κ monoclonal antibody. Quilizumab (anti-IgE) targets the M1-prime segment of membrane-expressed IgE, leading to depletion of IgE-switched and memory B cells. Quilizumab (anti-IgE) has the potantial for the asthma research. Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg

Product Properties

Isotype	Human IgG1
Light Chain Type	kappa
SDS-PAGE	146.5 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	1228538-47-3

References

1. Gauvreau GM, Harris JM, Boulet LP, Scheerens H, Fitzgerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y et al.. (2014) Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production.. Sci Transl Med, 6 (243): (243ra85). [PMID:24990880] [10.1021/op500134e]
2. Pennington LF, Gasser P, Brigger D, Guntern P, Eggel A, Jardetzky TS. (2021) Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions.. J Allergy Clin Immunol, 71 (13): (1755-70). [PMID:33991582] [10.1016/j.jaci.2021.03.050]
3. Kolkhir P, Altrichter S, Munoz M, Hawro T, Maurer M. (2020) New treatments for chronic urticaria.. Ann Allergy Asthma Immunol, 124 (1): (2-12). [PMID:31446134] [10.1021/op500134e]

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description