Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Q105030-1g | 1g | In stock | $31.90 | |
Q105030-5g | 5g | In stock | $99.90 | |
Q105030-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $343.90 | |
Q105030-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $961.90 |
Synonyms | (9R)-6'-methoxy-8alpha-cinchonan-9-ol | Quinoline alkaloid | Quinsan | (R)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol | GNF-Pf-506 | HMS2089E05 | (R)-(-)-Quinine, 6-methoxycinchonidine | DB00468 | EINECS 205-00 |
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Specifications & Purity | Moligand™, for fluorescence analysis, ≥98% |
Biochemical and Physiological Mechanisms | Potassium channel blocker |
Storage Temp | Protected from light,Argon charged |
Shipped In | Normal |
Grade | for fluorescence analysis, Moligand™ |
Action Type | AGONIST, CHANNEL BLOCKER, INHIBITOR |
Mechanism of action | Agonist of TAS2R14;Agonist of TAS2R40;Channel blocker of K 2P18.1;Channel blocker of K v2.2;Inhibitor of Plasma membrane monoamine transporter |
Product Description | Quinine is a primary alkaloid of various species of Cinchona, optical isomer of Quinidine and an anti-malarial, skeletal, muscle relaxant. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol |
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INCHI | InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1 |
InChi Key | LOUPRKONTZGTKE-WZBLMQSHSA-N |
Canonical SMILES | COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O |
Isomeric SMILES | COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O |
WGK Germany | 3 |
RTECS | VA6020000 |
PubChem CID | 3034034 |
Molecular Weight | 324.42 |
Beilstein | 91867 |
Reaxy-Rn | 5293630 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2103381 | Certificate of Analysis | May 17, 2024 | Q105030 |
H2103380 | Certificate of Analysis | May 13, 2024 | Q105030 |
H2103382 | Certificate of Analysis | May 13, 2024 | Q105030 |
H2103383 | Certificate of Analysis | May 13, 2024 | Q105030 |
C2422084 | Certificate of Analysis | Jun 01, 2022 | Q105030 |
H2206218 | Certificate of Analysis | Jun 01, 2022 | Q105030 |
H2206248 | Certificate of Analysis | Jun 01, 2022 | Q105030 |
H2206272 | Certificate of Analysis | Jun 01, 2022 | Q105030 |
Solubility | Soluble in alcohol, chloroform and diethyl ether. Slightly soluble in water and glycerol. |
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Sensitivity | Light & Moisture Sensitive. |
Melt Point(°C) | 173-177°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
WGK Germany | 3 |
RTECS | VA6020000 |
Reaxy-Rn | 5293630 |
Merck Index | 8061 |
1. Qing Li, Yu-Meng Guo, Xiang-Yi He, Guang-Li Li. (2023) Bifunctional Cu(II)-containing PDA-PEI copolymer dots: Demonstration of a dual-mode platform for colorimetric-fluorescent detection of glyphosate in the environment. TALANTA, 265 (124865). [PMID:37418960] [10.1016/j.talanta.2023.124865] |
2. Wu Xiao-yan, Lv Jin-yan, Zhang Shi-qing, Yi Xin, Xu Zi-wei, Zhi Yuan-xing, Zhao Bo-xin, Pang Jian-xin, Yung Ken Kin Lam, Liu Shu-wen, Zhou Ping-zheng. (2021) ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. ACTA PHARMACOLOGICA SINICA, 43 (4): (992-1000). [PMID:34341510] [10.1038/s41401-021-00739-9] |
3. Jun Yang, Hao Guo, Nan-Ji Jiang, Rui Tang, Guo-Cheng Li, Ling-Qiao Huang, Joop J. A. van Loon, Chen-Zhu Wang. (2021) Identification of a gustatory receptor tuned to sinigrin in the cabbage butterfly Pieris rapae. PLoS Genetics, 17 (7): (e1009527). [PMID:34264948] [10.1371/journal.pgen.1009527] |
4. Lin Yali, Liu Yu, Li Siqi, Rui Lili, Ou Jiming, Wu Quanzhou, He Jianfeng. (2021) Template-directed preparation of three-dimensionally ordered macroporous molecularly imprinted microspheres for selective recognition and separation of quinine from cinchona extract. JOURNAL OF POLYMER RESEARCH, 28 (5): (1-10). [PMID:] [10.1007/s10965-021-02533-x] |
5. Huan-Huan Ding, Mu-Han Zhao, Le Zhai, Jian-Bin Zhen, Le-Yun Sun, Jia-Zhu Chigan, Cheng Chen, Jia-Qi Li, Han Gao, Ke-Wu Yang. (2021) A quinine-based quaternized polymer: a potent scaffold with bactericidal properties without resistance. Polymer Chemistry, 12 (16): (2397-2403). [PMID:] [10.1039/D0PY01751E] |
6. Zhi-Yuan Zhang, Li-Li Rui, Ya-Li Lin, Hui-Dan Zhang, Ji-Ming Ou, Jian-Feng He, Quan-Zhou Wu. (2021) Preparation of ordered macroporous molecularly imprinted polymers and their applications in purifying cinchona alkaloids from cinchona extract. POLYMER INTERNATIONAL, 70 (9): (1344-1355). [PMID:] [10.1002/pi.6205] |
7. Pengli Zuo, Zhongguang Chen, Fengling Yu, Jinyu Zhang, Wei Zuo, Yanli Gao, Qingyou Liu. (2020) An easy synthesis of nitrogen and phosphorus co-doped carbon dots as a probe for chloramphenicol. RSC Advances, 10 (54): (32919-32926). [PMID:35516483] [10.1039/D0RA04228E] |
8. Hang Zhou, Jia Chen, Hui Li, Kaijun Quan, Yingshan Zhang, Hongdeng Qiu. (2020) Imidazolium ionic liquid-enhanced poly(quinine)-modified silica as a new multi-mode chromatographic stationary phase for separation of achiral and chiral compounds. TALANTA, 211 (120743). [PMID:32070598] [10.1016/j.talanta.2020.120743] |
9. Yin Yu, Yongxin Tao, Baozhu Yang, Datong Wu, Yong Qin, Yong Kong. (2017) Smart Chiral Sensing Platform with Alterable Enantioselectivity. ANALYTICAL CHEMISTRY, 89 (23): (12930–12937). [PMID:29125282] [10.1021/acs.analchem.7b03783] |
10. Yue Wang, Wen-ting Wu, Ming-bo Wu, Hong-di Sun, Hui Xie, Chao Hu, Xue-yan Wu, Jie-shan Qiu. (2015) Yellow-visual fluorescent carbon quantum dots from petroleum coke for the efficient detection of Cu2+ ions. NEW CARBON MATERIALS, 30 (550). [PMID:] [10.1016/S1872-5805(15)60204-9] |
11. Mingbo Wu, Yue Wang, Wenting Wu, Chao Hu, Xiuna Wang, Jingtang Zheng, Zhongtao Li, Bo Jiang, Jieshan Qiu. (2014) Preparation of functionalized water-soluble photoluminescent carbon quantum dots from petroleum coke. CARBON, 78 (480). [PMID:] [10.1016/j.carbon.2014.07.029] |
12. Qing Zhang, Yihan Huang, Liju Guo, Cui Chen, Dongmei Guo, Ya Chen, Yingzi Fu. (2014) DNA-based nanocomposite as electrochemical chiral sensing platform for the enantioselective interaction with quinine and quinidine. NEW JOURNAL OF CHEMISTRY, 38 (9): (4600-4606). [PMID:] [10.1039/C3NJ01559A] |
13. Li Liu, Xuecai Tan, Xiaoxue Fang, Yuexin Sun, Fuhou Lei, Zaiyin Huang. (2012) Electrochemical Sensor Based on Molecularly Imprinted Polymer Film Prepared with Functional Abietic-Type Acids as Cross-Linker for the Determination of Quinine. ELECTROANALYSIS, 24 (7): (1647-1654). [PMID:] [10.1002/elan.201200085] |
14. Qing Wang,Jing Li,Xin Yang,Li Xu,Zhi-guo Shi,Lan-Ying Xu. (2014-08-17) Investigation on performance of zirconia and magnesia-zirconia stationary phases in hydrophilic interaction chromatography.. Talanta, 129 (438-447). [PMID:25127617] |
15. Liyun Ma,Simin Liu,Qing Wang,Lin Yao,Li Xu. (2015-02-03) Cucurbit(6)uril immobilized on silica: a novel high-performance liquid chromatographic stationary phase.. Journal of separation science, 38 ((7)): (1082-1089). [PMID:25641573] |
1. Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK, Baliraine FN, Rosenthal PJ, D'Alessandro U. (2011) Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria.. Malar J, 10 (13): (144). [PMID:21609473] [10.1021/op500134e] |
2. Qing Li, Yu-Meng Guo, Xiang-Yi He, Guang-Li Li. (2023) Bifunctional Cu(II)-containing PDA-PEI copolymer dots: Demonstration of a dual-mode platform for colorimetric-fluorescent detection of glyphosate in the environment. TALANTA, 265 (124865). [PMID:37418960] [10.1016/j.talanta.2023.124865] |
3. Wu Xiao-yan, Lv Jin-yan, Zhang Shi-qing, Yi Xin, Xu Zi-wei, Zhi Yuan-xing, Zhao Bo-xin, Pang Jian-xin, Yung Ken Kin Lam, Liu Shu-wen, Zhou Ping-zheng. (2021) ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. ACTA PHARMACOLOGICA SINICA, 43 (4): (992-1000). [PMID:34341510] [10.1038/s41401-021-00739-9] |
4. Jun Yang, Hao Guo, Nan-Ji Jiang, Rui Tang, Guo-Cheng Li, Ling-Qiao Huang, Joop J. A. van Loon, Chen-Zhu Wang. (2021) Identification of a gustatory receptor tuned to sinigrin in the cabbage butterfly Pieris rapae. PLoS Genetics, 17 (7): (e1009527). [PMID:34264948] [10.1371/journal.pgen.1009527] |
5. Lin Yali, Liu Yu, Li Siqi, Rui Lili, Ou Jiming, Wu Quanzhou, He Jianfeng. (2021) Template-directed preparation of three-dimensionally ordered macroporous molecularly imprinted microspheres for selective recognition and separation of quinine from cinchona extract. JOURNAL OF POLYMER RESEARCH, 28 (5): (1-10). [PMID:] [10.1007/s10965-021-02533-x] |
6. Huan-Huan Ding, Mu-Han Zhao, Le Zhai, Jian-Bin Zhen, Le-Yun Sun, Jia-Zhu Chigan, Cheng Chen, Jia-Qi Li, Han Gao, Ke-Wu Yang. (2021) A quinine-based quaternized polymer: a potent scaffold with bactericidal properties without resistance. Polymer Chemistry, 12 (16): (2397-2403). [PMID:] [10.1039/D0PY01751E] |
7. Zhi-Yuan Zhang, Li-Li Rui, Ya-Li Lin, Hui-Dan Zhang, Ji-Ming Ou, Jian-Feng He, Quan-Zhou Wu. (2021) Preparation of ordered macroporous molecularly imprinted polymers and their applications in purifying cinchona alkaloids from cinchona extract. POLYMER INTERNATIONAL, 70 (9): (1344-1355). [PMID:] [10.1002/pi.6205] |
8. Pengli Zuo, Zhongguang Chen, Fengling Yu, Jinyu Zhang, Wei Zuo, Yanli Gao, Qingyou Liu. (2020) An easy synthesis of nitrogen and phosphorus co-doped carbon dots as a probe for chloramphenicol. RSC Advances, 10 (54): (32919-32926). [PMID:35516483] [10.1039/D0RA04228E] |
9. Hang Zhou, Jia Chen, Hui Li, Kaijun Quan, Yingshan Zhang, Hongdeng Qiu. (2020) Imidazolium ionic liquid-enhanced poly(quinine)-modified silica as a new multi-mode chromatographic stationary phase for separation of achiral and chiral compounds. TALANTA, 211 (120743). [PMID:32070598] [10.1016/j.talanta.2020.120743] |
10. Yin Yu, Yongxin Tao, Baozhu Yang, Datong Wu, Yong Qin, Yong Kong. (2017) Smart Chiral Sensing Platform with Alterable Enantioselectivity. ANALYTICAL CHEMISTRY, 89 (23): (12930–12937). [PMID:29125282] [10.1021/acs.analchem.7b03783] |
11. Yue Wang, Wen-ting Wu, Ming-bo Wu, Hong-di Sun, Hui Xie, Chao Hu, Xue-yan Wu, Jie-shan Qiu. (2015) Yellow-visual fluorescent carbon quantum dots from petroleum coke for the efficient detection of Cu2+ ions. NEW CARBON MATERIALS, 30 (550). [PMID:] [10.1016/S1872-5805(15)60204-9] |
12. Mingbo Wu, Yue Wang, Wenting Wu, Chao Hu, Xiuna Wang, Jingtang Zheng, Zhongtao Li, Bo Jiang, Jieshan Qiu. (2014) Preparation of functionalized water-soluble photoluminescent carbon quantum dots from petroleum coke. CARBON, 78 (480). [PMID:] [10.1016/j.carbon.2014.07.029] |
13. Qing Zhang, Yihan Huang, Liju Guo, Cui Chen, Dongmei Guo, Ya Chen, Yingzi Fu. (2014) DNA-based nanocomposite as electrochemical chiral sensing platform for the enantioselective interaction with quinine and quinidine. NEW JOURNAL OF CHEMISTRY, 38 (9): (4600-4606). [PMID:] [10.1039/C3NJ01559A] |
14. Li Liu, Xuecai Tan, Xiaoxue Fang, Yuexin Sun, Fuhou Lei, Zaiyin Huang. (2012) Electrochemical Sensor Based on Molecularly Imprinted Polymer Film Prepared with Functional Abietic-Type Acids as Cross-Linker for the Determination of Quinine. ELECTROANALYSIS, 24 (7): (1647-1654). [PMID:] [10.1002/elan.201200085] |
15. Qing Wang,Jing Li,Xin Yang,Li Xu,Zhi-guo Shi,Lan-Ying Xu. (2014-08-17) Investigation on performance of zirconia and magnesia-zirconia stationary phases in hydrophilic interaction chromatography.. Talanta, 129 (438-447). [PMID:25127617] |
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