Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Q105031-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $80.90 | |
Q105031-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $145.90 | |
Q105031-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $327.90 | |
Q105031-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,177.90 | |
Q105031-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $5,298.90 |
Potassium channel blocker
Synonyms | (9R)-6'-methoxy-8alpha-cinchonan-9-ol | Quinoline alkaloid | Quinsan | (R)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol | GNF-Pf-506 | HMS2089E05 | (R)-(-)-Quinine, 6-methoxycinchonidine | DB00468 | EINECS 205-00 |
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Specifications & Purity | Moligand™, ≥97% |
Biochemical and Physiological Mechanisms | Potassium channel blocker. Blocks small conductance Ca 2+ -activated K + channels. Inhibits TRPM7 currents. Shows antipyretic, antimalarial, analgesic, anti-inflammatory and anticonvulsant effects in vivo. Orally active. |
Storage Temp | Argon charged |
Shipped In | Normal |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Quinine is a primary alkaloid of various species of Cinchona, optical isomer of Quinidine and an anti-malarial, skeletal, muscle relaxant. Product Application: Quinine is used in photochemistry as a common fluorescence standard and as a resolving agent for chiral acids. It is also useful for treating falciparum malaria, lupus, arthritis and vivax malaria. It acts as a flavor component in tonic water and bitter lemon. It is utilized as the chiral moiety for the ligands used in sharpless asymmetric dihydroxylation. Furthermore, it catalyzes the kinetic resolution of furanones. |
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IUPAC Name | (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol |
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INCHI | InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1 |
InChi Key | LOUPRKONTZGTKE-WZBLMQSHSA-N |
Canonical SMILES | COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O |
Isomeric SMILES | COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O |
WGK Germany | 3 |
RTECS | VA6020000 |
PubChem CID | 3034034 |
Molecular Weight | 324.42 |
Beilstein | 91867 |
Reaxy-Rn | 5293630 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
C2416167 | Certificate of Analysis | Mar 01, 2024 | Q105031 |
C2416169 | Certificate of Analysis | Mar 01, 2024 | Q105031 |
C2416171 | Certificate of Analysis | Mar 01, 2024 | Q105031 |
B2224280 | Certificate of Analysis | Dec 25, 2021 | Q105031 |
B2224282 | Certificate of Analysis | Dec 25, 2021 | Q105031 |
B2224319 | Certificate of Analysis | Dec 25, 2021 | Q105031 |
B2401030 | Certificate of Analysis | Dec 25, 2021 | Q105031 |
C2420059 | Certificate of Analysis | Dec 25, 2021 | Q105031 |
G2431118 | Certificate of Analysis | Dec 25, 2021 | Q105031 |
I2311075 | Certificate of Analysis | Dec 25, 2021 | Q105031 |
K2314071 | Certificate of Analysis | Dec 25, 2021 | Q105031 |
Solubility | Soluble in alcohol, chloroform and diethyl ether. Slightly soluble in water and glycerol. |
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Sensitivity | Light & Moisture Sensitive. |
Melt Point(°C) | 173-177°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
WGK Germany | 3 |
RTECS | VA6020000 |
Reaxy-Rn | 5293630 |
Merck Index | 8061 |
1. Qing Li, Yu-Meng Guo, Xiang-Yi He, Guang-Li Li. (2023) Bifunctional Cu(II)-containing PDA-PEI copolymer dots: Demonstration of a dual-mode platform for colorimetric-fluorescent detection of glyphosate in the environment. TALANTA, 265 (124865). [PMID:37418960] |
2. Qing Wang,Jing Li,Xin Yang,Li Xu,Zhi-guo Shi,Lan-Ying Xu. (2014-08-17) Investigation on performance of zirconia and magnesia-zirconia stationary phases in hydrophilic interaction chromatography.. Talanta, 129 (438-447). [PMID:25127617] |
3. Liyun Ma,Simin Liu,Qing Wang,Lin Yao,Li Xu. (2015-02-03) Cucurbit(6)uril immobilized on silica: a novel high-performance liquid chromatographic stationary phase.. Journal of separation science, 38 ((7)): (1082-1089). [PMID:25641573] |
1. Cristea I et al.. (2021) K+ regulates relocation of Pellino-2 to the site of NLRP3 inflammasome activation in macrophages.. FEBS Lett, 595 (19): (2437-2446). [PMID:34387857] |
2. Qing Li, Yu-Meng Guo, Xiang-Yi He, Guang-Li Li. (2023) Bifunctional Cu(II)-containing PDA-PEI copolymer dots: Demonstration of a dual-mode platform for colorimetric-fluorescent detection of glyphosate in the environment. TALANTA, 265 (124865). [PMID:37418960] |
3. Qing Wang,Jing Li,Xin Yang,Li Xu,Zhi-guo Shi,Lan-Ying Xu. (2014-08-17) Investigation on performance of zirconia and magnesia-zirconia stationary phases in hydrophilic interaction chromatography.. Talanta, 129 (438-447). [PMID:25127617] |
4. Liyun Ma,Simin Liu,Qing Wang,Lin Yao,Li Xu. (2015-02-03) Cucurbit(6)uril immobilized on silica: a novel high-performance liquid chromatographic stationary phase.. Journal of separation science, 38 ((7)): (1082-1089). [PMID:25641573] |