Skip to the beginning of the images gallery

Quizartinib (AC220) - ≥99%, high purity , CAS No.950769-58-1, Inhibitor of colony stimulating factor 1 receptor;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase;Inhibitor of platelet derived growth factor receptor alpha;Inhibitor of platelet derived growth

Moligand™
≥99%

CAS#: 950769-58-1
Formula: C₂₉H₃₂N₆O₄S
Molecular Weight: 560.68
PubChem CID: 24889392
PubChem SID: 488200713

Item Number

Q127558

Grouped product items
SKU	Size	Availability	Price
Q127558-5mg	5mg	In stock	$64.90
Q127558-10mg	10mg	In stock	$90.90
Q127558-50mg	50mg	Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks.	$155.90
Q127558-500mg	500mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$848.90

Potent, selective Flt3 inhibitor

View related series

colony stimulating factor 1 receptor Inhibitor fms related receptor tyrosine kinase 3 Inhibitor KIT proto-oncogene，receptor tyrosine kinase Inhibitor platelet derived growth factor receptor alpha Inhibitor platelet derived growth factor receptor beta Inhibitor ret proto-oncogene Inhibitor

Basic Description

Synonyms	Quizartinib\|950769-58-1\|AC220\|Quizartinib (AC220)\|AC-220\|AC 220\|Quizartinib HCl\|AC010220\|vanflyta\|Quizartinib freebase\|1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea\|AC 010220\|ASP-2689\|7LA4O6Q0D3
Specifications & Purity	≥99%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of colony stimulating factor 1 receptor;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase;Inhibitor of platelet derived growth factor receptor alpha;Inhibitor of platelet derived growth
Product Description	Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 3. An Flt-3/Flk-2 inhibitor.

Associated Targets

CSF1R Tclin Macrophage colony-stimulating factor 1 receptor 7 Activities

Discover Target: CSF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RET Tclin Proto-oncogene tyrosine-protein kinase receptor Ret 13 Activities

Discover Target: RET

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 43 Activities

Discover Target: FLT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDGFRA Tclin Platelet-derived growth factor receptor alpha 7 Activities

Discover Target: PDGFRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDGFRB Tclin Platelet-derived growth factor receptor beta 7 Activities

Discover Target: PDGFRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KIT Tclin Mast/stem cell growth factor receptor Kit 14 Activities

Discover Target: KIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MYH10 Tchem Myosin-10 1 Activities

Discover Target: MYH10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488200713
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488200713
IUPAC Name	1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea
INCHI	InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
InChi Key	CVWXJKQAOSCOAB-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3
Isomeric SMILES	CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3
PubChem CID	24889392
Molecular Weight	560.68

CAS Registry No.

Wikipedia

DiscoveRx TREEspot

PubChem CID

ChEMBL Ligand

RCSB PDB Ligand

Reactome Reaction

R-HSA-9702510, R-HSA-9695831, R-HSA-9702618

Reactome Drug

R-ALL-9674318

DrugCentral Ligand

5341

PubChem SID

488200713

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

6 results found

Lot Number	Certificate Type	Date	Item
B2423037	Certificate of Analysis	Mar 01, 2024	Q127558
D2320861	Certificate of Analysis	Mar 15, 2023	Q127558
D2320868	Certificate of Analysis	Mar 15, 2023	Q127558
D2320869	Certificate of Analysis	Mar 15, 2023	Q127558
D2320885	Certificate of Analysis	Mar 15, 2023	Q127558
F1509079	Certificate of Analysis	Jan 25, 2023	Q127558

References

1. Chao Q, Sprankle KG, Grotzfeld RM, Lai AG, Carter TA, Velasco AM, Gunawardane RN, Cramer MD, Gardner MF, James J et al.. (2009) Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor.. J Med Chem, 52 (23): (7808-16). [PMID:19754199]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.