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2.7.1.40 Pyruvate kinases
(R)-(4-{1-benzyl-N-[(1-ethylpiperidin-4-yl)methyl]pyrrolidine-3-carboxamido}phenyl)arsonous acid , CAS No.R608987, Allosteric modulator of pyruvate kinase M1/2

(R)-(4-{1-benzyl-N-[(1-ethylpiperidin-4-yl)methyl]pyrrolidine-3-carboxamido}phenyl)arsonous acid , CAS No.R608987, Allosteric modulator of pyruvate kinase M1/2

Item Number

R608987

Grouped product items
SKU	Size	Availability	Price	Qty
R608987-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
R608987-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of pyruvate kinase M1/2

PKM Tchem Pyruvate kinase PKM (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	(R)-(4-{1-benzyl-N-[(1-ethylpiperidin-4-yl)methyl]pyrrolidine-3-carboxamido}phenyl)arsonous acid
INCHI	InChI=1S/C26H36AsN3O3/c1-2-28-15-12-22(13-16-28)19-30(25-10-8-24(9-11-25)27(32)33)26(31)23-14-17-29(20-23)18-21-6-4-3-5-7-21/h3-11,22-23,32-33H,2,12-20H2,1H3/t23-/m1/s1
InChi Key	LXEHZSWUYHSECE-HSZRJFAPSA-N
Canonical SMILES	C(c1ccccc1)N1C[C@@H](CC1)C(=O)N(CC1CCN(CC1)CC)c1ccc(cc1)[As](O)O

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1. Wang J, Zhou S, Cheng Y, Cheng L, Qin Y, Zhang Z, Bi A, Xiang H, He X, Tian X et al.. (2023) Selective Covalent Targeting of Pyruvate Kinase M2 Using Arsenous Warheads.. J Med Chem, 66 (4): (2608-2621). [PMID:36723914] [10.1021/op500134e]

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