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AAA ATPases
Enzymes
((R)-4-Phenyl-1-((R)-2-(pyrazine-2-carboxamido)pentanamido)butyl)boronic acid , CAS No.R608676, Inhibitor of lon peptidase 1; mitochondrial

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((R)-4-Phenyl-1-((R)-2-(pyrazine-2-carboxamido)pentanamido)butyl)boronic acid , CAS No.R608676, Inhibitor of lon peptidase 1; mitochondrial

Moligand™

PubChem CID: 155884491

Item Number

R608676

Grouped product items
SKU	Size	Availability	Price	Qty
R608676-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
R608676-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

lon peptidase 1，mitochondrial Inhibitor

Basic Description

Synonyms	compound 12d
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of lon peptidase 1; mitochondrial

Associated Targets

PSMB11 Tbio Proteasome subunit beta type-11 0 Activities

Discover Target: PSMB11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LONP1 Tchem Lon protease homolog, mitochondrial 0 Activities

Discover Target: LONP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	((R)-4-Phenyl-1-((R)-2-(pyrazine-2-carboxamido)pentanamido)butyl)boronic acid
INCHI	InChI=1S/C20H27BN4O4/c1-2-7-16(24-20(27)17-14-22-12-13-23-17)19(26)25-18(21(28)29)11-6-10-15-8-4-3-5-9-15/h3-5,8-9,12-14,16,18,28-29H,2,6-7,10-11H2,1H3,(H,24,27)(H,25,26)/t16-,18+/m1/s1
InChi Key	KSQVGVMZECCPAT-AEFFLSMTSA-N
Canonical SMILES	CCC[C@H](C(=O)N[C@H](B(O)O)CCCc1ccccc1)NC(=O)c1cnccn1
Isomeric SMILES	B([C@H](CCCC1=CC=CC=C1)NC(=O)[C@@H](CCC)NC(=O)C2=NC=CN=C2)(O)O
PubChem CID	155884491

Database links

RCSB PDB Ligand	UKS
PubChem CID	155884491

Certificates

Certificate of Analysis(COA)

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References

1. Kingsley LJ, He X, McNeill M, Nelson J, Nikulin V, Ma Z, Lu W, Zhou VW, Manuia M, Kreusch A et al.. (2021) Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.. J Med Chem, 129 (3): (589-97). [PMID:33821636]

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