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((R)-4-Phenyl-1-((R)-2-(pyrazine-2-carboxamido)pentanamido)butyl)boronic acid , CAS No.R608676, Inhibitor of lon peptidase 1; mitochondrial

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((R)-4-Phenyl-1-((R)-2-(pyrazine-2-carboxamido)pentanamido)butyl)boronic acid , CAS No.R608676, Inhibitor of lon peptidase 1; mitochondrial

Moligand™

PubChem CID: 155884491

Item Number

R608676

Grouped product items
SKU	Size	Availability	Price	Qty
R608676-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
R608676-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

lon peptidase 1，mitochondrial Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of lon peptidase 1; mitochondrial

Associated Targets(Human)

LONP1 Tchem Lon protease homolog, mitochondrial (1 Activities)

Discover Target: LONP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Lonp1 Lon protease homolog, mitochondrial (3 Activities)

Discover Target: Lonp1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	((R)-4-Phenyl-1-((R)-2-(pyrazine-2-carboxamido)pentanamido)butyl)boronic acid
INCHI	InChI=1S/C20H27BN4O4/c1-2-7-16(24-20(27)17-14-22-12-13-23-17)19(26)25-18(21(28)29)11-6-10-15-8-4-3-5-9-15/h3-5,8-9,12-14,16,18,28-29H,2,6-7,10-11H2,1H3,(H,24,27)(H,25,26)/t16-,18+/m1/s1
InChi Key	KSQVGVMZECCPAT-AEFFLSMTSA-N
Canonical SMILES	CCC[C@H](C(=O)N[C@H](B(O)O)CCCc1ccccc1)NC(=O)c1cnccn1
Isomeric SMILES	B([C@H](CCCC1=CC=CC=C1)NC(=O)[C@@H](CCC)NC(=O)C2=NC=CN=C2)(O)O
PubChem CID	155884491

Database links

RCSB PDB Ligand	UKS
PubChem CID	155884491

Certificates

Certificate of Analysis(COA)

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References

1. Kingsley LJ, He X, McNeill M, Nelson J, Nikulin V, Ma Z, Lu W, Zhou VW, Manuia M, Kreusch A et al.. (2021) Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.. J Med Chem, 71 (13): (1755-70). [PMID:33821636] [10.1021/acs.jmedchem.0c02152]

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