Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R288294-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $305.90 | |
R288294-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $484.90 | |
R288294-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,091.90 | |
R288294-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,964.90 | |
R288294-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $3,535.90 |
Diacylglycerol kinase inhibitor; increases PKC activity
Specifications & Purity | ≥98%(HPLC) |
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Biochemical and Physiological Mechanisms | Diacylglycerol (DAG) kinase inhibitor (IC50= 2.8μM); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Product Describtion: Diacylglycerol Kinase Inhibitor I prevents the formation of foreign body giant cell (FBGC). It inhibits the phosphorylation of diacylglycerol to phosphatidic acid. Diacylglycerol Kinase Inhibitor I functions as a serotonin (5-HT) receptor (5-HTR) antagonist. It stimulates apoptosis and autophagy in neuronal cell line NG108-15. Product application: Diacylglycerol Kinase Inhibitor I has been used as an inhibitor to study suppression of T cell function using advanced generation human CAR (chimeric antigen receptors) T cells. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 6-[2-[4-[(4-fluorophenyl)-phenylmethylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one |
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INCHI | InChI=1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3 |
InChi Key | MFVJXLPANKSLLD-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=CC=C4)C5=CC=C(C=C5)F)CC3 |
Isomeric SMILES | CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=CC=C4)C5=CC=C(C=C5)F)CC3 |
WGK Germany | 3 |
PubChem CID | 3012 |
Molecular Weight | 459.58 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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E2312575 | Certificate of Analysis | Apr 25, 2023 | R288294 |
E2312585 | Certificate of Analysis | Apr 25, 2023 | R288294 |
E2312589 | Certificate of Analysis | Apr 25, 2023 | R288294 |
E2312601 | Certificate of Analysis | Apr 25, 2023 | R288294 |
E2312602 | Certificate of Analysis | Apr 25, 2023 | R288294 |
Solubility | Solvent:ethanol, Max Conc. mg/mL: 9.19, Max Conc. mM: 20; Solvent:DMSO, Max Conc. mg/mL: 22.98, Max Conc. mM: 50 |
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WGK Germany | 3 |
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RIDADR | NONHforallmodesoftransport |