R 715, CAS No.185052-09-9, Antagonist of B 1 receptor

Features and benefits
    Item Number
    R287657
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    R287657-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $231.90

    Potent and selective B1antagonist

    View related series
    B1 receptor Antagonist

    Basic Description

    Product NameR 715, CAS No.185052-09-9
    GradeMoligand™
    Specifications & PurityMoligand™
    Biochemical and Physiological MechanismsPotent and selective bradykinin B1receptor antagonist (pA2= 8.49). Displays no activity at B2receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.
    SequenceKRPPGFSXI(Modifications: Lys-1 = N-terminal Ac, X = DβNal)
    Action TypeANTAGONIST
    Mechanism of actionAntagonist of B 1 receptor

    Associated Targets(Human)

    BDKRB1 Tchem B1 bradykinin receptor (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    BDKRB2 Tclin Bradykinin B2 receptor (3970 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Mechanisms of Action

    Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

    Product Specifications

    Storage TempStore at -20°C,Desiccated
    Shipped InIce chest + Ice pads
    CAS185052-09-9

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    Genetic information

    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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