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(R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT) - ≥98%, high purity , CAS No.78095-19-9
Selective full 5-HT 1A receptor agonist
Basic Description Synonyms (+)-8-OH-DPAT-HBR | R(+)-8-OH-DPAT (hydrobromide) | MLS001056795 | 8-HYDROXY-2-DIPROPYLAMINOTETRALIN HYDROBROMIDE, (+)- | EU-0100638 | SR-01000075925-1 | (+)-8-OH-DPAT HYDROBROMIDE | (+)8-OH-DPAT hydrobromide | 0S6YNT39TH | (+)-8-hydroxy-2-dipropylaminote Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Selective full 5-HT 1A receptor agonist. More active enantiomer of 8-OH-DPAT. Displays greater efficacy at 5-HT 1A . Also displays moderate affinity at 5-HT 7 . Inhibits amphetamine induced dopamine release. Storage Temp Protected from light,Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description 5-HT1A serotonin receptor agonist
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol;hydrobromide INCHI InChI=1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m1./s1 InChi Key BATPBOZTBNNDLN-PFEQFJNWSA-N Canonical SMILES CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O.Br Isomeric SMILES CCCN(CCC)[C@@H]1CCC2=C(C1)C(=CC=C2)O.Br PubChem CID 11957570 Molecular Weight 328.29
Chemical and Physical Properties Solubility H2O: >10 mg/mL at ±60 °C (with sonication)；<24.62mg/ml in DMSO；Methanol (Slightly) Sensitivity Light Sensitive；Moisture Sensitive Specific Rotation[α] [α]25/D +68.2°, c = 1 in methanol
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
References 1. Qian YW et al.. (2016) HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability.. J Biol Chem, 291 (44): (22977-22987). [PMID:27605665 ]
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