Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D118666-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $9.90 | |
D118666-5g | 5g | In stock | $19.90 | |
D118666-25g | 25g | In stock | $59.90 | |
D118666-100g | 100g | In stock | $199.90 |
Synonyms | lipoic acid | 1200-22-2 | (R)-lipoic acid | (R)-5-(1,2-Dithiolan-3-yl)pentanoic acid | (R)-alpha-Lipoic acid | (R)-(+)-1,2-Dithiolane-3-pentanoic acid | R-(+)-Thioctic acid | (+)-alpha-Lipoic acid | R-alpha-Lipoic acid | Thioctic acid d-form | D-Thioctic acid | 1,2-Dithiolane- |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | It was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. |
Storage Temp | Protected from light,Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms. |
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IUPAC Name | 5-[(3R)-dithiolan-3-yl]pentanoic acid |
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INCHI | InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1 |
InChi Key | AGBQKNBQESQNJD-SSDOTTSWSA-N |
Canonical SMILES | C1CSSC1CCCCC(=O)O |
Isomeric SMILES | C1CSS[C@@H]1CCCCC(=O)O |
WGK Germany | 3 |
PubChem CID | 6112 |
Molecular Weight | 206.33 |
Beilstein | 19(5)7,237 |
Reaxy-Rn | 81851 |
DrugBank Ligand | DB00166 |
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Wikipedia | Lipoic_acid |
CAS Registry No. | 1200-22-2 |
ChEBI | CHEBI:30314 |
PubChem CID | 6112 |
ChEMBL Ligand | CHEMBL134342 |
RCSB PDB Ligand | LPA |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2412227 | Certificate of Analysis | Jun 28, 2024 | D118666 |
G2412228 | Certificate of Analysis | Jun 28, 2024 | D118666 |
G2412231 | Certificate of Analysis | Jun 28, 2024 | D118666 |
G2412232 | Certificate of Analysis | Jun 28, 2024 | D118666 |
G2412236 | Certificate of Analysis | Jun 28, 2024 | D118666 |
C2429440 | Certificate of Analysis | Mar 08, 2024 | D118666 |
C2429441 | Certificate of Analysis | Mar 08, 2024 | D118666 |
J2318340 | Certificate of Analysis | Oct 09, 2023 | D118666 |
J2318339 | Certificate of Analysis | Oct 09, 2023 | D118666 |
D2425022 | Certificate of Analysis | Oct 09, 2023 | D118666 |
J2318335 | Certificate of Analysis | Oct 09, 2023 | D118666 |
J2318336 | Certificate of Analysis | Oct 09, 2023 | D118666 |
J2318337 | Certificate of Analysis | Oct 09, 2023 | D118666 |
J2318338 | Certificate of Analysis | Oct 09, 2023 | D118666 |
C2324762 | Certificate of Analysis | Jan 05, 2023 | D118666 |
C2324764 | Certificate of Analysis | Jan 05, 2023 | D118666 |
C2324752 | Certificate of Analysis | Jan 05, 2023 | D118666 |
L2207789 | Certificate of Analysis | Nov 24, 2022 | D118666 |
L2207810 | Certificate of Analysis | Nov 24, 2022 | D118666 |
L2207905 | Certificate of Analysis | Nov 24, 2022 | D118666 |
Solubility | Soluble in Dimethyl Sulfoxide and Methanol |
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Sensitivity | Moisture & Light & Air & Heat sensitive |
Specific Rotation[α] | +110.0 to +121.0 deg(C=1, EtOH) |
Flash Point(°F) | >230 °F |
Flash Point(°C) | >110 °C |
Melt Point(°C) | 47-51°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H412:Harmful to aquatic life with long lasting effects H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Reaxy-Rn | 81851 |
Merck Index | 9326 |
Starting at $32.90
1. Dengfeng He, Xingmou Liu, Jiezhi Jia, Bo Peng, Na Xu, Qing Zhang, Shang Wang, Lei Li, Menglong Liu, Yong Huang, Xiaorong Zhang, Yunlong Yu, Gaoxing Luo. (2023) Magnetic Field-Directed Deep Thermal Therapy via Double-Layered Microneedle Patch for Promoting Tissue Regeneration in Infected Diabetic Skin Wounds. ADVANCED FUNCTIONAL MATERIALS, 34 (2): (2306357). [PMID:29290964] |
2. Man Hu, Wen Jiang, Chen Ye, Ting Hu, Qingqing Yu, Moran Meng, Lijuan Sun, Jichao Liang, Yong Chen. (2023) Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK/SIRT1/PGC-1ɑ pathway in Schwann cells. PHYTOTHERAPY RESEARCH, [PMID:37580045] |
3. Jiaojiao Lu, Dawei Wang, Xin Li, Wei Guo, Chunyuan Tian, Feng Luan, Xuming Zhuang. (2023) Preparation of a Red−Emitting, Chitosan−Stabilized Copper Nanocluster Composite and Its Application as a Hydrogen Peroxide Detection Probe in the Analysis of Water Samples. Biosensors-Basel, 13 (3): (361). [PMID:36979573] |
4. Ying-Qi Yu, Wen-Qi Chen, Xiao-Han Li, Meng Liu, Xiao-Hang He, Yi Liu, Feng-Lei Jiang. (2023) Quantum Dots Meet Enzymes: Hydrophobicity of Surface Ligands and Size Do Matter. LANGMUIR, 39 (11): (3967–3978). [PMID:36877959] |
5. Wu Hao, Wei Guoli, Luo Lixia, Li Lingchang, Gao Yibo, Tan Xiaobin, Wang Sen, Chang Haoxiao, Liu Yuxi, Wei Yingjie, Song Jie, Zhang Zhenhai, Huo Jiege. (2022) Ginsenoside Rg3 nanoparticles with permeation enhancing based chitosan derivatives were encapsulated with doxorubicin by thermosensitive hydrogel and anti-cancer evaluation of peritumoral hydrogel injection combined with PD-L1 antibody. Biomaterials Research, 26 (1): (1-21). [PMID:36494759] |
6. Tianxing Zhou, Shuangcong Xie, Chunze Zhou, Yiyu Chen, Hong Li, Ping Liu, Rongjian Jiang, Lifeng Hang, Guihua Jiang. (2022) All-In-One Second Near-Infrared Light-Responsive Drug Delivery System for Synergistic Chemo-Photothermal Therapy. ACS Applied Bio Materials, 5 (8): (3841–3849). [PMID:35815771] |
7. Wen-Sen He, Yuying Sun, Zhishuo Li, Haonan Yang, Junjie Li, Qingzhi Wang, Chen Tan, Bin Zou. (2022) Enhanced antioxidant capacity of lipoic acid in different food systems through lipase-mediated esterification with phytosterols. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 102 (15): (7115-7125). [PMID:35704042] |
8. Qian Chen, Shuai Zhou, Yuan Ding, Dali Chen, Naseer Sintali Dahiru, Hailei Tang, Hui Xu, Meng Ji, Xueyi Wang, Zixuan Li, Qinying Chen, Yanan Li, Jiasheng Tu, Chunmeng Sun. (2022) A bio-responsive, cargo-catchable gel for postsurgical tumor treatment via ICD-based immunotherapy. JOURNAL OF CONTROLLED RELEASE, 346 (212). [PMID:35461965] |
9. Yingying Xu, Jie Ren, Wei Wang, An-Ping Zeng. (2021) Improvement of glycine biosynthesis from one-carbon compounds and ammonia catalyzed by the glycine cleavage system in vitro. ENGINEERING IN LIFE SCIENCES, 22 (1): (40-53). [PMID:35024026] |
1. Dengfeng He, Xingmou Liu, Jiezhi Jia, Bo Peng, Na Xu, Qing Zhang, Shang Wang, Lei Li, Menglong Liu, Yong Huang, Xiaorong Zhang, Yunlong Yu, Gaoxing Luo. (2023) Magnetic Field-Directed Deep Thermal Therapy via Double-Layered Microneedle Patch for Promoting Tissue Regeneration in Infected Diabetic Skin Wounds. ADVANCED FUNCTIONAL MATERIALS, 34 (2): (2306357). [PMID:29290964] |
2. Man Hu, Wen Jiang, Chen Ye, Ting Hu, Qingqing Yu, Moran Meng, Lijuan Sun, Jichao Liang, Yong Chen. (2023) Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK/SIRT1/PGC-1ɑ pathway in Schwann cells. PHYTOTHERAPY RESEARCH, [PMID:37580045] |
3. Jiaojiao Lu, Dawei Wang, Xin Li, Wei Guo, Chunyuan Tian, Feng Luan, Xuming Zhuang. (2023) Preparation of a Red−Emitting, Chitosan−Stabilized Copper Nanocluster Composite and Its Application as a Hydrogen Peroxide Detection Probe in the Analysis of Water Samples. Biosensors-Basel, 13 (3): (361). [PMID:36979573] |
4. Ying-Qi Yu, Wen-Qi Chen, Xiao-Han Li, Meng Liu, Xiao-Hang He, Yi Liu, Feng-Lei Jiang. (2023) Quantum Dots Meet Enzymes: Hydrophobicity of Surface Ligands and Size Do Matter. LANGMUIR, 39 (11): (3967–3978). [PMID:36877959] |
5. Wu Hao, Wei Guoli, Luo Lixia, Li Lingchang, Gao Yibo, Tan Xiaobin, Wang Sen, Chang Haoxiao, Liu Yuxi, Wei Yingjie, Song Jie, Zhang Zhenhai, Huo Jiege. (2022) Ginsenoside Rg3 nanoparticles with permeation enhancing based chitosan derivatives were encapsulated with doxorubicin by thermosensitive hydrogel and anti-cancer evaluation of peritumoral hydrogel injection combined with PD-L1 antibody. Biomaterials Research, 26 (1): (1-21). [PMID:36494759] |
6. Tianxing Zhou, Shuangcong Xie, Chunze Zhou, Yiyu Chen, Hong Li, Ping Liu, Rongjian Jiang, Lifeng Hang, Guihua Jiang. (2022) All-In-One Second Near-Infrared Light-Responsive Drug Delivery System for Synergistic Chemo-Photothermal Therapy. ACS Applied Bio Materials, 5 (8): (3841–3849). [PMID:35815771] |
7. Wen-Sen He, Yuying Sun, Zhishuo Li, Haonan Yang, Junjie Li, Qingzhi Wang, Chen Tan, Bin Zou. (2022) Enhanced antioxidant capacity of lipoic acid in different food systems through lipase-mediated esterification with phytosterols. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 102 (15): (7115-7125). [PMID:35704042] |
8. Qian Chen, Shuai Zhou, Yuan Ding, Dali Chen, Naseer Sintali Dahiru, Hailei Tang, Hui Xu, Meng Ji, Xueyi Wang, Zixuan Li, Qinying Chen, Yanan Li, Jiasheng Tu, Chunmeng Sun. (2022) A bio-responsive, cargo-catchable gel for postsurgical tumor treatment via ICD-based immunotherapy. JOURNAL OF CONTROLLED RELEASE, 346 (212). [PMID:35461965] |
9. Yingying Xu, Jie Ren, Wei Wang, An-Ping Zeng. (2021) Improvement of glycine biosynthesis from one-carbon compounds and ammonia catalyzed by the glycine cleavage system in vitro. ENGINEERING IN LIFE SCIENCES, 22 (1): (40-53). [PMID:35024026] |